Contraindications
Absolute:
- Hypersensitivity to the drug;
- Children under 6 years of age;
- Pregnancy (especially the first trimester);
- Breast-feeding;
- Severe chronic obstructive pulmonary disease;
- Severe depression;
- Myasthenia gravis, angle-closure glaucoma (acute attack, predisposition);
- Acute respiratory failure,
- Shock, coma;
- Acute alcohol intoxication, accompanied by weakening of vital functions;
- Acute intoxication with drugs that have a depressing effect on the central nervous system (psychotropic, hypnotics and narcotics).
Relative:
- Elderly age;
- Tendency to arterial hypotension;
- Increased risk of drug dependence;
- Kidney/liver failure;
- Cerebral and spinal ataxias;
- Hyperkinesis;
- Tendency to abuse psychotropic drugs;
- Organic diseases of the brain;
- Psychoses;
- Sleep apnea;
- Hypoproteinemia.
Indications for use
Tazepam is a tranquilizer that is a benzodiazepine derivative. The drug has a sedative and anxiolytic effect. The tablets also eliminate cramps and relax muscles.
The pharmacological effect of the drug is based on the stimulation of GABA processes in the brain. Tazepam primarily affects the reticular structure of the stem part, weakening the emotional background.
The instructions for Tazepam state that the medicine can be used as prescribed by a doctor in the following cases:
- Psychomotor agitation caused by alcohol abuse
- Neuroses
- Insomnia
- Reactive depression
- Autonomic disorders in women (PMS, menopause)
- Withdrawal syndrome.
Directions for use and dosage
Nozepam is taken orally, regardless of meals.
The initial dose is 10 mg (1 tablet) 2-3 times a day. The average daily dose for outpatient treatment is 30-50 mg, for inpatient treatment it is set individually, and in acute and severe conditions it can be increased to 120 mg.
For insomnia, it is recommended to take 1-3 tablets 1 hour before bedtime.
For alcohol withdrawal, 1-3 tablets are prescribed 3-4 times a day.
Elderly patients should take 1 tablet 3 times a day at the beginning of therapy. If the need arises, subject to good tolerance, the dose is increased to 2 tablets 3 times a day. You can take 1 tablet once a day. For patients over 65 years of age, the daily dose should not exceed 40 mg.
The duration of therapy is determined individually. The average course of treatment is 2-4 weeks.
The drug should be discontinued gradually.
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Side effects
- Central and peripheral nervous system: at the beginning of therapy (especially in older people) - drowsiness, fatigue, vertigo, gait instability, poor coordination of movements, impaired concentration, slowed motor and mental reactions, dullness of emotions, lethargy, ataxia; rarely - general weakness, dysarthria (blurred speech), depressed mood, euphoria, headache, memory impairment, confusion; tremor, muscle weakness during the day, depression, dystonic extrapyramidal reactions (uncontrolled movements, including the eyes), numbness; extremely rarely - paradoxical reactions (acute agitation, fear, hallucinations, anxiety, psychomotor agitation, irritability, aggressive outbursts, insomnia, muscle spasms, suicidal tendencies);
- Hematopoietic system: anemia, neutropenia, thrombocytopenia, leukopenia, agranulocytosis (sore throat, pyrexia, chills, unusual fatigue, weakness);
- Digestive system: drooling or dry mouth, heartburn, anorexia, diarrhea/constipation, nausea, vomiting, jaundice, increased activity of liver transaminases and alkaline phosphatase, liver dysfunction;
- Urinary system: urinary retention or incontinence, renal dysfunction;
- Reproductive system: dysmenorrhea, decreased or increased libido;
- Allergic reactions: rash and itching;
- Effect on newborns whose mothers took the drug during pregnancy: teratogenic effect, depression of the central nervous system, suppression of the sucking reflex, respiratory impairment;
- Other: lowering blood pressure, addiction, drug dependence; rarely - visual impairment, depression of the respiratory center, weight loss, bulimia, anterograde amnesia, tachycardia.
With a sharp reduction in dose or sudden cessation of taking Nozepam, withdrawal syndrome may develop: anxiety, fear, headache, agitation, irritability, dysphoria, nervousness, agitation, sleep disturbance, depersonalization, tremor, increased sweating, nausea, vomiting, depression, skeletal spasm muscles and smooth muscles of internal organs, hallucinations, convulsions, tachycardia, perception disorders, including photophobia, paresthesia, hyperacusis; rarely – acute psychosis.
Side effects
The following side effects may occur during treatment with Nozepam:
- drowsiness;
- headache;
- increased fatigue;
- decreased cognitive abilities;
- confusion;
- impaired coordination of movements;
- irritability and outbursts of aggression;
- suicidal tendencies;
- changes in blood composition;
- disruption of the digestion process;
- urinary incontinence;
- kidney failure;
- various allergic reactions;
- tachycardia;
- bulimia;
- vision pathologies.
With sudden cessation of treatment with Nozepam, withdrawal syndrome quite often occurs, which is accompanied by irritability, tachycardia, sleep problems, and acute psychosis.
special instructions
The medicine should be used with caution if there is a tendency to hypotension , an increased risk of drug dependence, insufficiency of liver or kidney function, in the elderly, with ataxia of the spinal and cerebral type, a tendency to abuse psychotropic drugs, hyperkinesis , organic diseases of the brain, hypoproteinemia, psychosis , night apnea.
Oxazepam is not recommended for long-term use due to the possibility of drug dependence.
With long-term treatment, it is necessary to monitor blood counts and liver function.
Any change in dosage should be made under the supervision of a physician.
During treatment with the drug, it is prohibited to drive vehicles.
Features of application
An overdose of diazepam can result in serious consequences such as asphyxia, cardiac depression, apnea, areflexia and coma.
If such conditions occur, an urgent visit to the hospital is necessary. As symptomatic therapy, a thorough gastric lavage is performed and sorbent drugs are prescribed.
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In emergency cases, artificial ventilation may be necessary.
Many people wonder whether diazepam is available with a prescription, or can you simply buy it at the pharmacy. The drug is dispensed only with a prescription prescribed by the attending physician, as it has a considerable number of side effects, which can negatively affect the general condition of the body if taken for other purposes.
The shelf life of the medicine is 3 years from the date of production. After this time, use is strictly prohibited. Storage conditions at a temperature of 15–25 degrees in a dry, dark place out of reach of children.
Diazepam and alcohol are incompatible concepts, since combination with alcohol can lead to increased blood circulation and disruption of the normal functioning of the cardiovascular system. The result of such experiments is a large number of complications and a possible fall into a coma with further death.
The drug is also categorically not recommended in the first trimester of pregnancy, as it can cause irreversible changes in the functioning of the heart in the developing fetus. During breastfeeding, the components of the drug are absorbed into the general bloodstream and enter the milk, which negatively affects the general condition of the baby.
