Release form and composition
Dosage form - lozenges: from almost white to white, flat-cylindrical in shape, with a separating line and chamfer; on two flat surfaces there is an inscription: on one - DIVAZA, on the side with a mark - MATERIA MEDICA (20 pieces in a contour strip pack, in a cardboard pack of 1, 2 or 5 packs).
1 tablet contains:
- active ingredients: antibodies to brain-specific protein S-100 - 0.006 g, antibodies to endothelial NO synthase - 0.006 g (each component is diluted 10012, 10030, 100200 times in an aqueous-alcohol solution and sequentially applied to lactose in the form of a mixture of three active dilutions );
- excipients: microcrystalline cellulose, lactose monohydrate, magnesium stearate.
How to take Divaza?
There have been no sufficient studies on the treatment of the above diseases with Divaza in children. Therefore, the drug is prescribed only to adults; therapy is not practiced in children under 18 years of age. Taking the medicine is very simple - it does not need to be washed down with water; it is taken by dissolving one dose in the mouth. The drug must be kept until completely dissolved; it should not be chewed or swallowed. The therapy does not depend on food. The treatment standards for this remedy are as follows:
- single dose - 1 tablet;
- on the recommendation of a doctor, you can take 2 tablets at a time;
- number of appointments per day - 3;
- in acute cases (after a stroke, head injury, poisoning, neuroinfection, etc.) you can drink Divaza up to 4-6 times a day.
The duration of the course of therapy is determined by the doctor. To normalize memory and increase mental performance, the course is 1-2 months. The same amount of treatment is recommended for insomnia and mild cognitive impairment. Organic damage to the nervous system will require a longer course - up to 4-6 months.
Pharmacological properties
Pharmacodynamics
Antibodies to the brain-specific protein S-100 have a neuroprotective, antioxidant, antihypoxic, anxiolytic effect, have membranotropic properties, modulate synaptic plasticity in the limbic structures of the brain, reticular formation, hippocampus, and enhance the inhibitory effect of gamma-aminobutyric acid in the central nervous system (CNS). They modify the functional activity of the S-100 protein, which couples metabolic and information processes in the brain. Restrains the processes of lipid peroxidation. They normalize the integrative activity of the brain, causing an antidepressant, anxiolytic, antiasthenic, antiamnestic, and neuroprotective effect.
Antibodies to endothelial NO synthase help increase the activity of the enzyme endothelial NO synthase, have an endothelial protective effect, eliminate endothelial dysfunction, restore its production of nitric oxide (NO), and influence NO-dependent vasodilation.
Divaza stimulates reparative processes at the site of ischemic brain damage.
The combined composition enhances the neuroprotective activity of antibodies to protein S-100, a vegetative stabilizing effect, and helps normalize vegetative status. Improves the integrative activity of the brain and restores its interhemispheric connections. The synergy of the two components has a positive effect on neuronal plasticity, which increases the brain's resistance to toxic influences. The drug helps eliminate cognitive impairment, stimulates reparative processes and restoration of central nervous system functions, increases mental performance, restores memory, increases cerebral blood flow, and normalizes somatovegetative manifestations.
Divaza does not have a sedative or muscle relaxant effect and is not addictive.
Pharmacokinetics
Studying the pharmacokinetics of the drug is technically impossible.
Indications for use
The drug is excellent for treating neurological diseases that are accompanied by decreased memory and mental performance. The medicine is most often prescribed to elderly patients and those who regularly experience mental overload. The following conditions are indicated:
- increased fatigue;
- physical, mental, mixed asthenia;
- changes in cognitive functions;
- learning disability;
- various types of memory impairment;
- decreased motivation;
- depressive states (in complex therapy);
- anxiety, emotional lability.
The drug helps against headaches, dizziness, and is also indicated for sleep disorders (insomnia, disturbances in sleep phases and the process of falling asleep). Divaza helps reduce asthenovegetative symptoms, so the medicine is indicated for vegetative-vascular dystonia.
In addition to functional disorders, Divaza tablets help with organic diseases of the brain and cerebral vessels.
The drug is prescribed after infections (meningitis, encephalitis), after traumatic brain injuries, or a stroke.
It is useful to take the drug for cerebrovascular pathologies, chronic circulatory disorders (atherosclerosis, vascular spasms). You can also take the medicine during a stressful period at work, when preparing for exams, to eliminate the effects of intoxication - alcohol, nicotine, drugs.
Important instructions
In order for the treatment to be as effective as possible, you need to take Divaza tablets correctly. Feedback from doctors confirms the fact that those patients who followed all the doctors’ recommendations and followed the dosage noticed significant changes in their health within two weeks after starting treatment. And a month later the condition was approaching ideal. Of course, patients with severe traumatic brain injuries took a little longer to recover.
Please note that this medicine can be taken by people driving a car, as well as working with serious mechanisms that require concentration and care. The components included in the medication do not affect the speed of psychomotor reactions
Also, do not forget that the medicine contains lactose, so the drug should not be taken by patients with galactose deficiency, congenital galactosemia and glucose-galactose malabsorption syndrome.
The instructions for use do not say about the interaction of Divaza tablets and alcohol. However, keep in mind that according to doctors, it is better to completely abstain from alcoholic beverages during treatment. This way you will speed up the healing process and will not worsen your health.
In addition, the drug will not have a negative effect on the kidneys and liver, so it can be safely used even by patients suffering from insufficiency of these organs.
In addition, this medication can be combined with any other medications. Therefore, doctors very often prescribe this remedy as one of the components of complex treatment of diseases of the central nervous system.
Comparison of the effectiveness of Divaza and Nootropil
Nootropil is more effective than Divaza - this means that the ability of the medicinal substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Nootropil is more pronounced, then with Divaza it is impossible to achieve this effect even in large doses.
Also, the speed of therapy is an indicator of the speed of the therapeutic action; Nootropil and Divaza are also different, as is bioavailability - the amount of the drug reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Comparison of the safety of Divaza and Nootropil
The safety of a drug includes many factors.
At the same time, in Divaza it is quite similar to Nootropil. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Divaza, as well as Nootropil, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Divaza does not have any risks when used, just like Nootropil.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Divaza and Nootropil.
Medication use by special groups of patients
Studies on the safety of using Divaza by pregnant and lactating women have not been conducted. Therefore, it is not known whether the drug has teratogenic or other negative effects on the fetus and child.
Only a doctor can prescribe medication during pregnancy after analyzing the potential benefits for the mother and the possible risk to the fetus.
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During lactation, breastfeeding should be stopped during treatment.
The use of the drug for the treatment of persons under 18 years of age is prohibited. This is due to the lack of clinical trials in this category of patients.
Terms of purchase and storage
A package of Divaza contains 100 tablets, its average price is 300-350 rubles. The drug should be stored in a place protected from sunlight at room temperature not exceeding 25 degrees Celsius.
It is important that the storage location is not accessible to children. You do not need a doctor's prescription to purchase.
At this time, no pharmaceutical company produces analogue drugs for Divaza; if it is necessary to replace the drug, you can select an appropriate product with a different composition, but a similar effect on the body:
- Gammalon;
- Nevrin;
- Vinebral;
- Actovegin;
- Intellan and others.
Comparison of ease of use of Divaza and Nootropil
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Divaza is approximately the same as Nootropil. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2019-11-30 11:07:38
Reviews about Divaza
Reviews about Divaz are contradictory. There are more bad ones, many believe that this is a typical homeopathic dummy, and the active substance is of dubious origin.
Some people like this drug:
- Good medicine, well tolerated. The effect is very fast. Already on the fifth day of taking it, my head became clearer. The medicine does not cause aggression like most nootropics and is reasonable for the price.
But the majority do not agree with this, considering this result to be a “placebo effect”, when a person really believes that any medicine helps in mild cases.
There are also those who believe that Divaza can harm:
- This medicine made me feel sick. After taking it, I started feeling dizzy and suffered from insomnia at night. Not only did it not help at all, it also caused harm.
Although this is a homeopathic remedy, it is sold in regular pharmacies.
Price: 100 Divaza tablets cost 320 rubles.
Contraindications and side effects
Divaza does not produce a sedative effect, does not provoke drowsiness or lethargy in patients during the day, and does not relax muscles. This drug can be taken for a long time without fear, as there is no addiction or dependence on the treatment.
Due to the form of administration and the presence of only homeopathic components, Divaza does not have a negative effect on the heart, kidneys, stomach, or intestines.
There are few contraindications to treatment with Divaza. The drug should not be taken if you are allergic to lactose, since milk sugar is included in the components.
You should also not drink the product if you have the following conditions:
- intestinal form of allergy to components;
- syndrome of malabsorption of glucose, galactose;
- Congenital lactase deficiency.
Usually taking the drug does not cause side effects. Only with an overdose there is a risk of developing diarrhea, digestion problems, and abdominal pain. During pregnancy and lactation, taking Divaza is possible only under strict indications.
Analogues of the drug Divaza
Analogues are determined by structure:
- Energy ball.
- Neuromet.
- Noben.
- Lutsetam.
- Cerebrolysin.
- Hopantenic acid.
- Noocetam.
- Combitropil.
- Bilobil.
- Encephabol.
- Tenoten.
- Pikogam.
- Phezam.
- Glutamic acid.
- Omaron.
- Cortexin for children.
- Pantocalcin.
- Aminalon.
- Cortexin.
- Cerepro.
- Memotropil.
- Stamin.
- Semax.
- Phenotropil.
- Piracetam.
- Intellan.
- Nootropil.
- Pirabene.
- Picamilon.
- Calcium hopantenate.
- Vinpotropil.
- Cerutile.
- Anvifen.
- Pyracesin.
- Thiocetam.
- Phenibut.
- Ceraxon.
- Mexipridol.
- Gliatilin.
- Noofen.
- Mexiprim.
- Tenoten for children.
- Pantogam.
- Cereton.
- Cerebrolysate.
- Tenoten.
- Noopept.
- Glycine.
- Idebenone.
The group of nootropics includes:
- Escotropile.
- Mexicofin.
- Cebrilyzin.
- Tenoten for children.
