Compound
The active component of the drug is citicoline sodium, which has the following properties:
- has a stabilizing effect on the membrane;
- reduces cerebral edema;
- weakens the severe symptoms of cerebral dysfunction resulting from injury or acute circulatory disorders in the brain;
- helps reduce the level of amnesia, etc.
Depending on the form of release of the drug, the main substance is supplemented with auxiliary components that improve the absorption of the drug by the body.
The list of components used by the manufacturer includes:
- sorbitol;
- methyl parahydroxybenzoate;
- glycerol;
- sodium citrate dihydrate;
- propyl parahydroxybenzoate;
- sodium saccharinate;
- potassium sorbate;
- strawberry flavor (strawberry essence 1487-S-Lucta);
- citric acid (50% solution);
- purified water.
Compound. pharmachologic effect
The active ingredient of the drug is citicoline. Citicoline is able to restore damaged tissue and reduce the content of free radicals, as a result the patient experiences improved tissue nutrition and respiration. It also contains other excipients that help improve the condition and speed up recovery.
As for the spectrum of action of citicoline, they are as follows:
- Restores cell membranes that have been damaged.
- Improves cholinergic transmission in brain tissue.
- Helps reduce the severity of neurological symptoms and the duration of post-traumatic coma in TBI.
- Prevents the formation of free radicals.
- Acts as an inhibitor against phospholipases.
- Able to reduce damage to brain tissue during the acute period of stroke.
- It has a positive effect on motor and sensory neurological disorders that have a vascular and degenerative etiology.
Ceraxon is effective for many cognitive disorders and helps reduce the manifestations of amnesia. The drug is absorbed by the gastrointestinal tract, then gradually distributed throughout the tissues of the body, and the metabolic process itself takes place in the intestines and liver.
How to take Ceraxon in solution
The injection is carried out both intravenously and intramuscularly. An infusion of the solution may also be prescribed.
The medicine is administered slowly over 3-5 minutes. depending on the dosage prescribed by the doctor. Administration through a dropper must be done at a rate of 40 to 60 drops per minute.
During the rehabilitation period, 500 to 2000 mg of medication per day is prescribed. The duration and daily dosage are calculated according to the nature and severity of symptoms. Elderly persons do not require dosage adjustment.
Experts recommend the drug in the following cases:
- acute period of cerebral catastrophe - stroke;
- recovery period after already suffering brain damage;
- acute or already recovery period after TBI;
- various pathologies of brain structures of a vascular nature of development, in combination with various behavioral disorders and cognitive abilities in the patient.
Only a neurologist should recommend a nootropic drug - after assessing the individual severity of neurological symptoms, the patient’s age category, and his susceptibility to the treatment procedures being performed.
For premature infants - 50 mg twice a day, for babies from two months - 100 mg in the morning and evening. Then the child’s dose is adjusted, but should not exceed 20 ml of medication per day.
Ceraxon solution is taken orally, following the following algorithm:
- Place the dosing syringe into the bottle (the syringe plunger must be completely lowered);
- Carefully pull the plunger of the dosing syringe until the solution level is equal to the corresponding mark on the syringe;
- Take the syrup internally, after dissolving it in half a glass of water;
- After each use, it is recommended to rinse the dosing syringe with water.
In order to take the contents of a packet of Ceraxon solution inside, it is necessary to separate one bag from the other along the tear seam. Holding the bag vertically, carefully tear off its edge along the edge and drink the contents. Before taking, Ceraxon syrup can be diluted in 120 ml of water.
In order to get advice from a neurologist about taking Ceraxon solution orally, make an appointment by phone.
Head of the Research Center for Parkinson's Disease, neurologist, Doctor of Medical Sciences, Professor
Pharmacokinetics
Since Citicoline is a natural compound found in the human body, it is impossible to determine the pharmacokinetic properties because endogenous citicoline and endogenous citicoline cannot be separated.
Removal of the drug from the body takes a long time and is carried out through the respiratory tract or through the kidneys. After 5 days of taking the medicine, about 16% was found, to which we can say that the rest was involved in metabolism.
Reviews of treatment for children with autistic behavior
Recovery after a stroke of any etiology is a very complex and often lengthy process. “Cerakson” as an independent remedy rarely shows really good results. However, reviews from some patients, on the contrary, are extremely positive and confirm the fact that the restoration of brain functions occurs quickly.
There are also many negative reviews from relatives of those patients for whom the medicine did not help restore their condition to an acceptable level. Much depends on age and the individual clinical picture of the disease.
The drug is prescribed to both adults and children during the recovery period after various types of traumatic brain injuries. In some cases, taking it is not advisable - only a neurologist can make an accurate verdict on the need to take a particular medication after receiving the results of X-ray and MRI of the brain.
Reviews from patients who took the drug during the recovery period after TBI are varied. Some note that cognitive functions were restored very quickly, headaches went away, unmotivated irritability decreased, and sleep phases were restored. But other patients, on the contrary, note the complete uselessness of taking the drug. Possibly, negative reviews were provoked by the fact that the dosage was incorrectly selected or concomitant medications for treatment were incorrectly selected.
You can find reviews about the drug "Ceraxon".
In the cold, crystals may form in the solution that is taken orally. But if further storage is ensured in a warm room, then the crystals gradually dissolve. This will happen in a few months.
The effects of levodopa are enhanced while taking the medication. Concomitant use of meclofenoxate is not recommended. This is confirmed by the instructions for the drug "Ceraxon". For children (there are reviews on this matter), you can choose analogues. Let's consider them further.
Cerakson is prescribed quite often to children with autistic behavior of varying severity. Autism is an incurable disease, but it is possible to correct a child’s behavior and condition almost to normal with the help of special classes. Nootropics and Ceraxon, as well as anticonvulsants (if necessary) are an excellent help in this case.
Reviews from parents indicate that children become attentive and collected, and better assimilate information while taking the drug. However, there are also negative reviews that report the complete pointlessness of taking medications with citicoline for autism.
Reviews of Cerakson syrup, used to treat children with delayed psycho-speech development, vary. Some children showed excellent results - meaningful sentences appeared, speech progressed significantly. There are also negative reviews that indicate the almost complete uselessness of the drug for such pathologies in children.
Reviews
Reviews from doctors and patients about the drug Ceraxon are mostly positive.
Reviews from doctors
It is worth noting the key ones:
- The main advantage is that it is non-toxic! I prescribe the drug to patients without fear, there were even several female patients who were 6 months pregnant (Konstantinov S.M.).
- Some patients developed severe allergies, be careful and see a doctor (Murmansky E.K.).
- The drug is very effective, it helps greatly during the rehabilitation period after a stroke (Zhuravleva R.I.).
Release form and price
The medicine is intended for internal use and is available in several versions:
- syrup (capacity 30 ml);
- injection solution (in ampoules of 4 ml);
- tablets (pack of 20 pcs.);
- powder for preparing a suspension (a sachet containing 10 g of the drug; after dilution, 100 ml of the finished solution is obtained).
The cost of the drug differs depending on the purpose and volume of the container.
You can buy a pharmacological agent in Moscow at the price:
- syrup (30 ml, 100 mg) – 757 rubles;
- injections (5 ampoules of 4 ml, 500 mg) – 719 rubles;
- injections (5 ampoules of 4 ml, 1000 mg) – 1239 rubles;
- solution (10 sachets of 10 ml, 100 mg) – 1495 rub.
Finding out how much the drug costs is available in an online pharmacy or on an information and reference website, where, after entering your place of stay, nearby pharmacies that sell the pharmaceutical product are displayed.
Contraindications
The use of a nootropic drug is contraindicated in the presence of an allergy to one of the components included in the composition, as well as in cases of VSD with severe syndrome.
You should stop using the product if you are diagnosed with rare genetic diseases associated with an allergy to fructose.
Instructions for use indicate that Ceraxon should not be taken if:
- sensitivity to individual components;
- not recommended for use by patients with high tone of the parasympathetic nervous system;
- patients under 18 years of age (due to lack of clinical studies);
- rare genetic diseases that lead to fructose intolerance.
No dose adjustment of the drug is required.
Instructions for use (Method and dosage)
Among the main ones it is worth noting the following:
- serious cerebral circulatory disorders;
- treatment of complications resulting from circulatory disorders in the brain;
- mechanical damage to the brain and its consequences;
- decrease in memory, mental performance and other cognitive functions caused by various types of vascular pathologies of the brain.
Instructions for use indicate that Ceraxon should not be taken if:
- sensitivity to individual components;
- not recommended for use by patients with high tone of the parasympathetic nervous system;
- patients under 18 years of age (due to lack of clinical studies);
- rare genetic diseases that lead to fructose intolerance.
No dose adjustment of the drug is required.
Indications for use of the drug are as follows:
- acute period of ischemic stroke;
- recovery after hemorrhagic and ischemic strokes;
- acute and recovery period after traumatic brain injury;
- vascular diseases of the brain, accompanied by behavioral and cognitive disorders.
The medicine Ceraxon is contraindicated in the following conditions:
- high sensitivity to the components that the drug contains;
- pronounced vagotonia (the tone of the parasympathetic part of the autonomic nervous system predominates);
- hereditary diseases in which fructose intolerance is noted.
The instructions for Ceraxon for intravenous and intramuscular administration are as follows. The medicine is administered intravenously slowly, depending on the dose, over 3-5 minutes.
If the drug is taken by drip at a rate of 40–60 drops per minute. If possible, it is preferable to take the drug intravenously rather than intramuscularly.
Instructions for using Ceraxon also depend on the disease that is diagnosed in the patient. In the acute period of traumatic brain injury and ischemic stroke, 1000 mg of the drug should be administered every 12 hours, the course of therapy continues for at least 6 weeks.
The doctor prescribes the dosage of the drug during the recovery period individually, depending on the severity and severity of the symptoms. Ceraxon is administered to children strictly as prescribed by the doctor and in accordance with the dosage indicated by him. Elderly patients do not need to adjust the usual dosage.
When taken orally, the drug is diluted in half a glass of water. You need to drink it while eating food or between meals. In the acute period of TBI or stroke, 1000 mg (10 ml or one packet) is prescribed every 12 hours, treatment lasts at least 6 weeks.
For children, Ceraxon syrup is prescribed for lesions of the central nervous system of varying severity. Instructions for syrup for children are individual and depend on the severity of the lesion, the age of the child, reaction to the medicine, etc.
READ MORE: Cereton instructions for use reviews
For newborns born very prematurely, syrup is prescribed twice a day, 0.5 ml (50 mg), for children over two months of age - 1 ml (100 mg) twice a day.
Further treatment is individually prescribed by the doctor, and the child should not take more than 5-20 ml of the drug per day. The solution contained in the ampoule should be used once.
The main medical indication for parenteral administration of Ceraxon solution is complex therapy of various pathological conditions affecting the structures of the central nervous system:
- Restoring the functional state of the brain after an ischemic or hemorrhagic stroke.
- Complex therapy of the acute period of ischemic stroke.
- Treatment of the acute and recovery period after a traumatic brain injury.
The drug is also used for complex treatment of behavioral and cognitive disorders in elderly people developing against the background of degenerative-dystrophic and vascular pathology of the brain.
Parenteral administration of Ceraxon injection solution is excluded in certain pathological and physiological conditions of the patient’s body, which include:
- Severe vagotonia is a state of significant increase in the functional activity of the parasympathetic part of the autonomic nervous system.
- The patient's age is under 18 years, since there are no reliable data on the safety and effectiveness of the drug.
- Individual intolerance to any of the components of this drug.
Before prescribing a solution for parenteral administration of Ceraxon, the doctor must rule out the presence of contraindications in the patient.
acute period of ischemic stroke (as part of complex therapy);
recovery period of ischemic and hemorrhagic strokes;
TBI, acute (as part of complex therapy) and recovery period;
cognitive and behavioral disorders in degenerative and vascular diseases of the brain.
Contraindications
The drug is taken regardless of the time of meal (with food or in between).
For convenience, the solution is diluted in water (120-150 ml).
The dosage for adults is determined by the doctor, taking into account the etiology of the disease and the patient’s condition:
- In case of acute cerebrovascular accident, accompanied by paralysis and loss of consciousness, TBI - a single dose of 1000 mg or 10 ml. The treatment regimen involves taking the medication twice a day, the course of treatment is at least 6 weeks.
- At the stage of the recovery process after a sharp disturbance of cerebral circulation, TBI, in degenerative and vascular diseases characterized by behavioral and cognitive disorders - a daily dose of 500-2000 mg with 1-2 single doses of the drug. When determining the duration of treatment, the extent of damage to brain cells and the consequences of attacks are taken into account.
The effectiveness of the active substance is noted:
- with SRD (speech development delay);
- for the treatment of congenital diseases of the nervous system;
- for epilepsy;
- with increased intracranial pressure;
- for recovery after serious injuries, surgery and illness.
The nootropic drug in pediatrics is used in all forms of release with the following dosage of citicoline:
- Syrup – 1 ml/100 mg;
- Injections – 500-1000 mg in 4 ml ampoule;
- Powdered composition - sachet with 10 g of medicine;
- Tablets – 500 mg.
The presence of different options for doses of the active substance and release forms make it possible to use Ceraxon from the first days of life:
- For children under one year of age, a daily dose of 1-3 ml is recommended, taken twice a day.
- The age group of 1-5 years assumes the use of a single dose of 1-3 ml with two doses.
- Patients from 6 to 11 years old are prescribed 3-4 ml twice a day.
- For adolescents over 14 years of age, the rate increases to 5 ml with twice-daily use of the medication.
- Injections are given intramuscularly using a dose of 200-400 mg 2 times a day.
Children under one year of age are often recommended to use the solution in the form of syrup or injection. For convenience, the syrup is mixed with breast or artificial milk (a small amount) and given to the baby from a bottle.
Indications for newborn patients include:
- intrauterine oxygen starvation;
- hypoxia caused by labor;
- premature babies requiring a ventilator.
Dose for infants – 0.5 ml, number of doses per day – twice, course of treatment – up to 12 weeks.
Let's study the instructions for use for the drug Ceraxon.
Mode of application
It is worth considering that the method of application depends on the type of substance:
- A substance for intravenous administration is used by slowly injecting the medication intravenously (over 3-5 minutes in accordance with the prescribed dose). If the intravenous drip method is used, then the infusion should occur at an infusion rate of 40-60 drops/min. For elderly patients. When prescribing a prescription to elderly patients, no dosage adjustment is required. The Ceraxon product can be used with all types of intravenous isotope and dextrose solutions.
- Substance for oral administration. Before use, the medicine can be diluted with water (115-125 ml). The method of administration by injecting the drug into a vein is considered more common than intramuscular administration of the drug. When administering a substance intramuscularly, it is recommended to avoid injecting the drug into an area of muscle tissue that has already been used to administer the drug previously. The substance in the ampoule is used once. After opening the ampoule, the medicine should be used immediately.
Release forms
The drug is available in the form:
- substance for introduction into the human body by injection - a clear, colorless and odorless liquid in ampoules of 4 ml (500 or 1000 mg);
- substance for oral administration - a clear, colorless liquid with the smell of strawberries;
- film-coated tablets.
Dosages
Dosages of Ceraxon in the form of a substance intended for injection:
- In case of ischemic stroke, failure of the correct functioning of the brain as a result of difficulties or complete cessation of blood flow to one or another area, as well as in case of acute mechanical damage to the brain, the recommended dose is 10 ml every twelve hours; after a week of treatment, switch to oral use. The course of treatment is one and a half months.
- During the period of rehabilitation after experiencing various types of strokes. The recommended dose is 5-10 ml twice a day. The course of treatment and dose recommended for use are determined by the attending physician and depend on the severity of the patient's condition.
- In case of disruptions in the normal functioning of the brain, the recommended dose for use is 5-10 ml, twice a day. The course of treatment and dose recommended for use are determined by the attending physician and depend on the severity of the patient's condition.
Another popular drug for eliminating circulatory problems, Vinpocetine, instructions for use, price in pharmacies and reviews are discussed in our article.
A rare but unpleasant disease, Meniere's syndrome, the causes and treatment of which are described in detail in our material, requires a special approach and knowledge.
Indications for use of the drug are:
- Traumatic brain injury (acute and recovery periods) and complications caused by it.
- Ischemic and hemorrhagic stroke (acute and recovery periods).
- Neurological disorders caused by degenerative and vascular changes.
- Cerebrovascular accident.
- Complications caused by cerebral hypoxia.
- Disorders caused by disruption of the cerebral vessels.
acute period of ischemic stroke (as part of complex therapy);
recovery period of ischemic and hemorrhagic strokes;
TBI, acute (as part of complex therapy) and recovery period;
cognitive and behavioral disorders in degenerative and vascular diseases of the brain.
Indications for use
The main clinical indication for parenteral administration of drug solutions is combination therapy of various pathological conditions that affect the structures of the nervous system:
- restoration of brain functionality after hemorrhagic or ischemic stroke;
- complex treatment of ischemic stroke in the acute period;
- therapy of the acute and recovery period of traumatic brain injuries.
In addition, this drug is prescribed for the complex treatment of cognitive and behavioral disorders in elderly people that develop against the background of vascular and degenerative pathologies of the brain.
Compatibility with alcoholic drinks
Ethyl alcohol, which is included in absolutely all alcoholic drinks, is toxic to cells of the nervous system and provokes their death. Parallel intake of alcoholic beverages while taking Cerakson reduces the treatment to nothing and is meaningless. If you need to drink, you should think about visiting a narcologist.
"Cerakson", unlike other drugs that restore blood circulation to the brain, is not prescribed during the period of withdrawal and post-withdrawal syndrome. In some cases, when taking the drug together with ethyl alcohol, it is possible to increase the toxic effect not only on neurons, but also on liver cells.
Side effects
Possible effects associated with exposure to citicoline include:
- sleep disturbance;
- dyspnea;
- loss of appetite;
- slight destabilization of the psycho-emotional background (apathy, agitation);
- numbness felt in areas of paralyzed limbs;
- loose stools;
- vomit;
- short-term change in blood pressure;
- decreased activity of liver enzymes.
If there is hypersensitivity to certain substances, the body reacts characteristic of an allergy.
If side effects increase and your health condition deteriorates sharply, you should seek qualified medical help.
Side effects may occur when using Ceraxon:
- Skin rashes, skin itching;
- Anaphylactic shock;
- Dizziness, headache;
- Trembling of limbs;
- Hallucinations;
- Insomnia; excitation.
When selecting drugs for complex treatment, it should be taken into account that the active substance (citicoline) enhances the effect of levodopa.
Ceraxon should not be taken in combination with drugs containing meclofenoxate.
To minimize side effects and various complications, it is recommended to refrain from drinking alcoholic beverages during drug therapy. This is especially true for pregnant women (any trimester of pregnancy).
If unusual situations arise, a one-time combination of alcohol and drugs is possible, but drinks must be consumed in compliance with the following intervals:
- syrup and solution – 24 hours for men, 32 hours for women;
- injections – 15 days after completion of the course of treatment.
To relieve anxiety symptoms, you need to stop drinking alcohol and drink more water (especially the first 4-6 hours). If the condition worsens, you should seek qualified help.
Mechanism of action
Thanks to the action of the drug:
- improves the functions of neuronal membranes;
- helps improve the functioning of ion exchange pumps by stimulating the natural synthesis of structural phospholipids in the human body;
- reduction of the area affected by the infarction during ischemia.
Side effects may occur when using Ceraxon:
- Skin rashes, skin itching;
- Anaphylactic shock;
- Dizziness, headache;
- Trembling of limbs;
- Hallucinations;
- Insomnia; excitation.
Overdose and additional instructions
Cases of using a dose of the drug in excess of the norm have not been recorded, since the toxicity of the drug is extremely low.
Side effects
Among the main side effects:
- impaired breathing (shortness of breath);
- various types of allergic reactions (skin rash, itching, anaphylactic shock);
- loss of appetite;
- gastrointestinal disorders, etc.;
- problems with the cardiovascular system (differences in blood pressure, feeling hot);
- problems of the central nervous system (tremor of the limbs, hyperexcitability, hallucinations, etc.).
special instructions
Please note that:
- During pregnancy and lactation, treatment with Cerakson is prescribed only when absolutely necessary, when the intended benefit of its use outweighs the possible risk. Although no studies have been conducted on the effect of the drug on the fetus.
- There are no research results on the possibility of the substance passing into breast milk, but as a rule, it is recommended to stop breastfeeding.
- Children. Cerakson is usually not prescribed to patients under 18 years of age due to a lack of clinical studies. Impact on the ability to control vehicles when working with complex mechanisms. Ceraxon does not affect the ability to control vehicles when working with complex mechanisms. In some cases, some side effects associated with disruption of the central nervous system may affect the ability to control vehicles when working with complex mechanisms.
This product should not be used in parallel with medications that contain parachlorophenoxyacetic acid b-dimethylaminoethyl ester hydrochloride.
During pregnancy, treatment with Ceraxon is prescribed only when absolutely necessary, when the expected benefit of its use outweighs the possible risk. Although no studies have been conducted on the effect of the drug on the fetus.
In a solution for oral administration in the cold, a small amount of crystals sometimes forms due to temporary partial crystallization of the preservative. Upon further storage under recommended conditions, the crystals dissolve. Their presence does not affect the quality of the drug. During treatment with Ceraxon, patients are advised to exercise caution when performing potentially hazardous activities that require special attention and rapid psychomotor reactions:
- Driving a car and other vehicles;
- Working with moving mechanisms;
- Perform the duties of a dispatcher and operator.
Citicoline (the main ingredient of Ceraxon) enhances the effects of levodopa. The drug is not prescribed simultaneously with drugs that contain meclofenoxate. Get examined and treated at the Yusupov Hospital by making an appointment by phone.
Psychotherapist, doctor of the highest category
Cerakson
pharmachologic effect
Nootropic drug.
Citicoline, being a precursor of key ultrastructural components of the cell membrane (mainly phospholipids), has a wide spectrum of action: it promotes the restoration of damaged cell membranes, inhibits the action of phospholipases, preventing the excessive formation of free radicals, and also prevents cell death by affecting the mechanisms of apoptosis.
In the acute period of stroke, citicoline reduces the volume of brain tissue damage and improves cholinergic transmission.
In case of traumatic brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms; in addition, citicoline helps to reduce the duration of the recovery period.
In chronic cerebral hypoxia, citicoline is effective in the treatment of cognitive disorders such as memory impairment, lack of initiative, and difficulties in performing daily activities and self-care. Increases the level of attention and consciousness, and also reduces the manifestation of amnesia.
Ceraxon® is effective in the treatment of sensory and motor neurological disorders of degenerative and vascular etiology.
Pharmacokinetics
Suction
Citicoline is well absorbed when taken orally, intravenously and intramuscularly. Absorption after oral administration is almost complete, and bioavailability is approximately the same as after intravenous administration.
Metabolism
When taken orally, the drug is metabolized in the intestines and liver to form choline and cytidine. After oral administration, the concentration of choline in the blood plasma increases significantly.
With IV and IM administration, citicoline is metabolized in the liver to form choline and cytidine. After parenteral administration, the concentration of choline in the blood plasma increases significantly.
Distribution
Citicoline is widely distributed in brain structures, with rapid incorporation of choline fractions into structural phospholipids and cytidine fractions into cytidine nucleotides and nucleic acids. Citicoline penetrates the brain and is actively incorporated into cellular, cytoplasmic and mitochondrial membranes, forming part of the fraction of structural phospholipids.
Removal
Only 15% of the administered dose of citicoline is excreted from the human body; less than 3% - by the kidneys and about 12% - with exhaled CO2.
The excretion of citicoline in urine can be divided into 2 phases: a first phase, lasting about 36 hours, during which the rate of excretion decreases rapidly, and a second phase, during which the rate of excretion decreases much more slowly. The same is observed in exhaled CO2 - the rate of elimination decreases rapidly after about 15 hours and then decreases much more slowly.
Indications
— acute period of ischemic stroke (as part of complex therapy);
— recovery period of ischemic and hemorrhagic strokes;
— traumatic brain injury, acute (as part of complex therapy) and recovery period;
— cognitive and behavioral disorders in degenerative and vascular diseases of the brain.
Dosage regimen
Oral solution
The drug is taken with meals or between meals. Before use, the drug can be diluted in a small amount of water (120 ml or 1/2 cup).
Acute period of ischemic stroke and traumatic brain injury:
The recommended dose is 1000 mg (10 ml) every 12 hours. The duration of treatment is at least 6 weeks.
Recovery period of ischemic and hemorrhagic strokes, recovery period of traumatic brain injury, cognitive and behavioral disorders in degenerative and vascular diseases of the brain:
The recommended dose is 500-2000 mg/day (5-10 ml 1-2 times/day). The dose and duration of treatment depend on the severity of the symptoms of the disease.
Elderly patients
No dose adjustment of Ceraxon® is required.
Rules for using a dosage syringe
1. Place the dosing syringe into the bottle (the syringe plunger is completely lowered).
2. Carefully pull the plunger of the dosing syringe until the solution level is equal to the corresponding mark on the syringe.
3. Before taking, the required amount of solution can be diluted in 1/2 glass of water (120 ml).
After each use, it is recommended to rinse the dosing syringe with water.
Solution for intravenous and intramuscular administration
The drug is administered intravenously as a slow injection (over 3-5 minutes, depending on the prescribed dose) or drip infusion (40-60 drops per minute). The intravenous route of administration is preferable to the intramuscular route. When administered intramuscularly, repeated administration of the drug in the same place should be avoided.
Acute period of ischemic stroke and traumatic brain injury:
the recommended dose is 1000 mg every 12 hours from the first day after diagnosis; Duration of treatment is at least 6 weeks. 3-5 days after the start of treatment (if swallowing function is not impaired), it is possible to switch to oral forms of the drug Ceraxon®.
Recovery period for ischemic and hemorrhagic strokes, recovery period for traumatic brain injury, cognitive and behavioral disorders in degenerative and vascular diseases of the brain:
The recommended dose is 500-2000 mg/day (5-10 ml 1-2 times/day). The dose and duration of treatment depend on the severity of the symptoms of the disease.
Elderly patients
dose adjustment of the drug Ceraxon® is not required for intravenous or intramuscular administration.
A solution for intravenous and intramuscular administration in an ampoule is intended for single use. After opening the ampoule, the solution should be used immediately. The drug is compatible with all types of intravenous isotonic solutions and dextrose solutions.
Side effect
Side effects are observed very rarely (<1/10,000), including isolated cases.
Allergic reactions:
rash, skin itching, anaphylactic shock.
From the nervous system:
headache, dizziness, tremor, hallucinations, insomnia, agitation, numbness in paralyzed limbs, stimulating effect on the parasympathetic system.
From the digestive system:
nausea, vomiting, diarrhea, loss of appetite, changes in the activity of liver enzymes.
Other:
feeling of heat, short-term changes in blood pressure, swelling, shortness of breath.
Contraindications
- pronounced vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system);
- children and adolescents under 18 years of age (due to the lack of sufficient clinical data);
- hypersensitivity to the components of the drug.
Pregnancy and lactation
There is not enough clinical data on the use of Ceraxon during pregnancy. Although experimental studies on animals have not revealed any negative effects, during pregnancy the drug is prescribed only when the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided, since there is no data on the excretion of citicoline in breast milk.
special instructions
In the solution for oral administration in the cold, a small amount of crystals may form due to temporary partial crystallization of the preservative. With further storage under recommended conditions, the crystals dissolve within several months. The presence of crystals does not affect the quality of the drug.
Impact on the ability to drive vehicles and operate machinery
During the treatment period, patients should be careful when performing potentially hazardous activities that require special attention and quick psychomotor reactions (including driving a car and other vehicles, working with moving mechanisms, working as a dispatcher and operator).
Overdose
Due to the low toxicity of the drug, cases of overdose have not been described.
Drug interactions
Citicoline enhances the effects of levodopa.
Ceraxon® should not be prescribed concomitantly with medications containing meclofenoxate.
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
The drug should be stored out of the reach of children at a temperature not exceeding 30°C. Shelf life: 3 years.
Interaction with other drugs
The nootropic drug Ceraxon has analogues with an identical composition:
- Neupilept Sotex (injection solution, 125 mg, 5 amp.) – 535 rubles; 250 mg – 830 rub.;
- Recognan Alpha Wasserman (solution, 10 sachets of 10 ml, 100 mg) – RUB 1,359;
- Ceresil Canon Armavir Biological Factory (injections, 250 mg, 5 amps) – 805 rub.
Among the famous:
- Vinpocetine (tablets, ampoules) – from 24 to 190 rubles per pack;
- Vinpotropil (capsules) – from 145 rubles;
- Cavinton (ampoules) – from 215 rubles.
Only the attending physician should decide what to replace Cerakson with, taking into account the real picture of the disease and the characteristics of the body.
Not everyone can afford to buy Ceraxon, so below are product analogues, or so-called generics.
A vasodilator that helps improve blood circulation.
Indications:
- treatment of psychoorganic syndrome of any origin;
- acute and chronic vascular diseases;
- inflammatory and infectious diseases of the central nervous system.
Memotropil
Indications:
- diseases of the central nervous system;
- circulatory disorders in the brain;
- depression.
Helps improve blood circulation, improve metabolic processes in the brain, and causes an increase in the concentration of denosine triphosphoric acid.
Indications:
- serious cerebral circulatory disorders;
- treatment of complications resulting from circulatory disorders in the brain.
