Medicine ADAPTOL, instructions for use, contraindications and side effects

Analogues of the drug according to ATC codes:

AFOBAZOLE BROMODIHYDROCHLORPHENYLBENZODIAZEPINE MEBICAR NEUROPHAZOL TENOTEN CHILDREN'S TETRAMETHYLTETRAAZABICYCLOOCTANEDIONE (MEBICAR) PHENAZEPAM PHENAZEPAM PHENAZEPAM PHENORELAXAN ELZEPAM All

Why is Adaptol prescribed?

The drug helps in the following cases:

neuroses and neurosis-like states (irritability, emotional instability, anxiety and fear);
to improve the tolerability of neuroleptics and tranquilizers in order to eliminate the somatovegetative and neurological side effects they cause;
cardialgia of various origins (not associated with ischemic heart disease);
nicotine withdrawal (as part of complex therapy as a means of reducing the desire to smoke tobacco).

Adaptol is used as the main remedy for nervous disorders of varying severity.

pharmachologic effect

Anxiolytic (tranquilizer). Adaptol is close in chemical structure to the body's natural metabolites - its molecule consists of two methylated urea fragments that are part of the bicyclic structure.

Adaptol acts on the activity of structures included in the limbic-reticular complex, in particular, on the emotiogenic zones of the hypothalamus, and also has an effect on all 4 main neurotransmitter systems: GABA-, choline-, serotonin- and adrenergic, promoting their balance and integration, but does not have a peripheral adrenergic blocking effect.

Eliminates or weakens worry, anxiety, fear, internal emotional tension and irritability. The calming effect is not accompanied by muscle relaxation and impaired coordination of movements.

It does not reduce mental and motor activity, so Adaptol can be used during the working day or school. Does not create an elevated mood or a feeling of euphoria.

It does not have a hypnotic effect, but enhances the effect of sleeping pills and improves sleep in case of sleep disturbances.

Adaptol eases or relieves nicotine withdrawal.

In addition to having a calming effect, it has a nootropic effect. Adaptol improves cognitive functions, attention and mental performance without stimulating the symptoms of productive psychopathological disorders - delirium, pathological emotional activity.

Reviews

Despite the fact that Adaptol is sold strictly according to a prescription, there are a huge number of reviews of this product online. And they cannot be called unambiguous.

All patients who have ever tried this remedy were divided into two camps: those for whom it became salvation, and those for whom it became torment. Those saved by the remedy claim that after the first use the medicine gave them calm and indifference to the surrounding stress. Many people suffering from serious nervous shocks (and there were many of them) claim that only Adaptol helped them and nothing else. These patients did not notice any side effects or addiction; the only drawback they call is the bitter taste of the medicine; the pills are sometimes difficult to take due to the extremely pungent and unpleasant taste.

The second conditional group of patients are those for whom the drug not only did not help, but also worsened their condition. This situation was especially encountered by people who officially had a diagnosis related to disorders of the nervous system (clinical depression, postpartum depression, VSD accompanied by panic attacks, neuroses, etc.). These patients claim that the drug caused an exacerbation and intensification of many of the symptoms they were trying so hard to get rid of. Many claim that panic, fears have appeared, irritability has worsened, breathing problems (when there is not enough air in the chest), headaches and sleep disturbances have appeared. After stopping Adaptol, the symptoms subsided, returning to their starting point.

If you have personal experience using Adaptol, please share it in the comments with our readers. Your review can help many people decide on their choice of medicine.

Pharmacokinetics

Suction

After oral administration, Adaptol is well absorbed from the gastrointestinal tract (77-80%). Cmax of the active substance in blood plasma is achieved 0.5 hours after taking the drug. The high concentration of the active substance persists for 3-4 hours, then gradually decreases.

Distribution

Up to 40% of the dose taken is bound to red blood cells. The rest does not bind to plasma proteins and is found in the blood plasma in a free form, so the active substance is freely distributed throughout the body and freely overcomes cell membranes.

Metabolism

The active substance is not metabolized and does not accumulate in the body.

Removal

About 55-70% of the dose taken is excreted from the body in the urine, the rest is excreted unchanged in feces during the day.

Release form and composition

The drug is available in tablet form.
The tablets are white, round, flat-cylindrical in shape with a score and a chamfer. The drug is packaged in cardboard packs of 20 tablets each.

The active component in the composition is tetramethyltetraazabicyclooctanedione (1 tablet contains 500 mg of the substance).

Auxiliary components are calcium stearate (1.7 mg) and methylcellulose (3.3 mg).

special instructions

If blood pressure and/or body temperature decrease (possibly by 1-1.5°C), there is no need to stop taking the drug. Blood pressure and body temperature normalize on their own.

If allergic reactions occur, use of the drug should be discontinued.

Addiction, addiction and withdrawal syndrome to Adaptol have not been established.

Impact on the ability to drive vehicles and operate machinery

The drug can cause a decrease in blood pressure and weakness, which can negatively affect the ability to drive vehicles and operate machinery. Caution should be exercised when used in patients engaged in potentially hazardous activities.

Contraindications

The drug has a fairly narrow range of contraindications, which makes it a universal drug for different categories of patients. A few contraindications include:

Individual intolerance to one or more components in the composition.
Pregnancy and breastfeeding period.
The drug should not be taken by children and adolescents under 18 years of age.

The product should not be used by children, since there is no data on a clinical study of the effects of Adaptol on the children's body.

The use of the drug in adolescence is allowed, but this practice is exceptional and is carried out under the strict supervision of the attending physician.

Pregnancy

It is forbidden to take by pregnant and lactating women.

Instructions for use of Adaptol for children, reviews from doctors and mothers, dosage for tics

Adaptol is prescribed to children to treat tics, reduce anxiety and nervousness. The main form of release is tablets, dosage of 500 mg. The medicine has a calming effect, does not cause increased drowsiness or addiction, and is therefore approved for the treatment of children.

Can it be given to children?

The instructions for use indicate that the tablets should not be given to children under 18 years of age. However, if there are indications, the drug can be prescribed to a child from 9-10 years of age. The drug is strictly contraindicated for children under 6-8 years of age, as unpredictable reactions may occur.

The liver and kidneys of a small child will not be able to process such a medicine. Although many children tolerate it well, the risk of side effects in children is too high and does not justify the therapeutic effect.

If a doctor prescribes a tranquilizer to a child, he takes all possible consequences under his own responsibility. The doctor carefully selects the dosage, and in case of complications, promptly discontinues the drug or replaces it with an analogue. This is why you should never give Adaptol to children on your own.

It is especially dangerous to use a tranquilizer in combination with antipsychotics. A combination of drugs taken at night has a powerful hypnotic effect. This causes apnea (sudden stoppage of breathing) in some children. The child is not able to come out of medicated sleep on his own and may die.

How does the medicine work?

The main component in the composition is tetramethyltetraazabicyclooctanedione in a dosage of 500 mg. The substance is a mild tranquilizer, reduces anxiety and irritation, improves mood and concentration, and reduces nervous tone during tics.

Parents doubt whether Adaptol can be given to children, mistakenly classifying it as an antidepressant. In fact, it is a mild sedative and does not affect cognitive functions.

Adaptol treats neurotic disorders, VSD, phobias and panic attacks, and emotional lability. The drug is included in the course of therapy after myocardial infarction. In pediatrics, the tranquilizer has found a place in the treatment of attention deficit hyperactivity disorder. Teenagers with signs of alcohol and drug addiction are also treated with this drug.

Instructions and dosage

The instructions for use of Adaptol do not indicate children's dosages, but it is known that a child over 6 years of age is prescribed 1/4 or 1/3 tablet up to 3 times a day. Children from 10 years of age can be given 300-500 mg up to 3 times a day. The dosage of the drug for adolescents in the treatment of nicotine addiction is 600-900 mg up to 3 times a day.

Each child is prescribed an individual dose, taking into account the specifics of the disease, so self-medication is strictly prohibited. You can take the tablets before, during or after meals. The course of therapy lasts from 3-5 days to several months.

Adverse reactions

Taking Adaptol may cause the following side effects:

Increased weakness;
Vertigo;
Allergic rash;
Intestinal disorder;
Pain in the epigastric region.

In case of an accidental overdose, the temperature and pressure decrease, sudden weakness occurs, and there may be bronchospasm. In this case, symptomatic therapy is carried out in the form of gastric lavage and sorbents.

Analogs and price

The main analogues include:

Mebix;
Mebicar;
Phenozepam;
Tenoten;
Afobazol.

In Moscow pharmacies the price for a package of Adaptol is 560-900 rubles. If you order the drug from an online pharmacy, the price will be slightly lower, about 520 rubles.

Reviews from doctors and mothers

Neurologists speak of the drug as the most effective method of treating hyperactivity, developmental delay, autism and psychopathy in children. It is recommended to start with small dosages of 200 mg, with a gradual increase in dose. Doctors' reviews of the drug also indicate that the medicine does not cause addiction or side effects.

Feedback from moms is also positive. After a course of therapy, hysterics and phobias disappear, children become concentrated and learn the material better. If there was a history of sleep disorders, mothers notice that after Adaptol the child began to sleep deeper, nightmares and insomnia disappeared.

Children gain self-confidence, a joyful mood and a desire to explore the world around them return. When tics occur, nervous hypertonicity decreases and the eyes and limbs stop twitching. All these changes occur thanks to the feeling of inner peace that Adaptol gives.

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Overdose

The instructions for Adaptol stipulate that the tablets can be taken regardless of the meal period. As a rule, patients are prescribed from 300 mg to 500 mg of the drug 2-3 times a day. The drug is prescribed for a period of 2 days to 3 months, depending on the diagnosis and characteristics of the course of the disease.

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The drug is prescribed to children from the age of ten. Children are prescribed a dose of 300-500 mg three times a day. The treating specialist will tell you in detail about the treatment features.

This medicine has low toxicity. Therefore, in case of an overdose of the drug, a typical overdose pattern is observed. When taking very large doses of the drug, hypotension, dizziness, and weakness may occur.

If there is a suspicion of an overdose of Adaptol, symptomatic therapy is practiced, and gastric lavage is also performed.

Reviews from doctors and mothers about the treatment of tics in children with Adaptol. Is Adaptol effective for VSD?

Does it help with VSD and panic attacks?

The effectiveness of the drug depends on the severity and stage of VSD and the severity of certain symptoms. In most reviews, Adaptol has too weak an effect on panic attacks accompanying VSD. The best option would be to regularly take medications specifically designed for panic attacks associated with VSD.

pharmachologic effect

Adaptol is a medicine belonging to the group of anxiolytic drugs. The drug has a tranquilizing effect.

Effectively relieves feelings of fear, anxiety, eliminates irritability, anxiety, and reduces strong emotional stress.

The effect of this medicine is not accompanied by changes in motor functions and muscle relaxation, or a decrease in mental activity. Thus, the drug is considered a daytime tranquilizer.

Adaptol tablets do not have a hypnotic effect, but at the same time potentiate the effect of drugs that are used to treat sleep disorders .

The drug provides an antioxidant effect, which is especially clearly manifested under stress of various origins, accompanied by oxidative phenomena.

The drug has antagonist-agonist properties of the adrenergic system. Dopamine is noted , and therefore a normosthenic effect is noted.

When taking tablets, the severity of withdrawal symptoms decreases in people who have stopped smoking tobacco.

The active substance affects the emotiogenic zones of the hypothalamus and the four main neurotransmitter systems, ensuring their balance and integration. In this case, there is no adrenergic blocking peripheral effect.

The nootropic effect of the drug is also noted. Adaptol activates cognitive functions, improves mental activity and attention.

Different patients - different effects

The main problem is that VSDs like to take medications based on the reviews of their friends in misfortune.

This is why there are so many conflicting reviews about the same drug on forums. All medications must be selected individually by a doctor.

It also happens that the drug is selected through “trial and error”, since not all reactions of the body and the patient’s central nervous system can be predicted.

Adaptol is prescribed to patients with VSD:

To eliminate symptoms of dystonia, such as nervousness, mild forms of depression, anxiety for no reason, emotional instability, tearfulness, fear, sleep problems, neuroses of various forms.
To “relieve side effects” during treatment with antidepressants (Adaptol helps to survive the body’s adaptation to other drugs, which it combines well with).
For cardiac crises that are not associated with organic damage to the heart muscle.
With exacerbation of VSD during nicotine withdrawal.

You should know that Adaptol is not suitable in case of frequent hypotensive crises, since it lowers blood pressure.

The drug is also capable of increasing extrasystoles, and many patients, trying to relieve another attack with a pill, only aggravate its course and duration.

Adaptol for VSD and panic attacks, which manifest themselves severely and vividly, will not be of much benefit. Its effect is too mild, while harsher drugs are needed to relieve the symptoms of PA.

Undoubtedly, a course of treatment with Adaptol can help in individual cases to reduce the frequency of PA, but if the course is stopped, everything will return to normal.

Thus, the drug is not useful for every patient, and, despite the mildness of the effect, it can aggravate some symptoms.

Also, many VSDs note that the drug is disgustingly bitter and can not only ruin the appetite, but also cause vomiting.

Note: the Latvian drug Adaptol has a Russian analogue, Mebicar, which is almost 3 times cheaper.

Indications

Used in dogs for fear of noises and explosions (fireworks, fireworks, thunderstorms, gunshots, etc.

); when parting with the owner (fear of loneliness, temporary separation); with early weaning of puppies from their mother; when a new family member appears; during and after a visit to the veterinarian; during transportation; when there is a change of owner, development of a new house; to eliminate many manifestations of anxiety, reduce nervous excitement, to correct various forms of behavior caused by fear or stress

Reviews

On forums on the Internet you can find the following reviews about Adaptol:

Maria . My child is already 15 years old. Due to increased excitability and aggression, the doctor prescribed the tranquilizer Adaptol. I didn’t notice any effect, although almost a month has passed since the day I took it. The doctor claims that we still need to wait. I'll watch, if it doesn't help, I'll turn to another doctor.
Tatiana . I have a son, 6 years old. As part of complex therapy, the neurologist prescribed Adaptol, half a tablet twice a day. The dose seemed too high to me, so I started giving 1/4 capsule. Only a few days have passed, but the effect is already clearly visible: the child feels better, he looks at many things more easily and has stopped getting hung up. I hope it will be even better.
Sofia . My daughter is 7 years old, she has had a difficult character since birth. She has been under the care of a very good neurologist since she was two years old. I follow all his recommendations. Recently, a doctor prescribed Adaptol at a dose of 250 mg once a day. A week later, the girl became calmer and more flexible. Her mood improved. I didn't notice any visible side effects. Therefore, they consider the drug to be good.

Forms of release of the drug and conditions of release from pharmacies

Available in tablet form. The capsules are round, flat-cylindrical, have an identifying mark and chamfer. Painted white. Packaged in cellular contour plates in quantities of 10 pieces and packed in cardboard boxes. Adaptol is dispensed from pharmacies strictly according to prescription .

At what age is it allowed to take it?

The instructions for use of Adaptol contain information that the medicine should not be used by people under 18 years of age. This is due to the lack of research on children's reactions to this drug. However, many doctors allow the prescription of this medication in pediatric practice if there are grounds for such a prescription.

Moreover, the minimum age at which Adaptol is prescribed to children is usually 9-10 years.

For children aged 8 years, 6 years or younger, especially at 3 years old, even experienced neurologists do not recommend this medicine, because the reaction to the drug in such children can be unpredictable.

For example, taking Adaptol before bed in combination with antipsychotics can provoke apnea, which threatens the child’s life at night.
In addition, the baby's kidneys or liver may not be able to cope with this medicine. And although Adaptol is well tolerated in most cases, the risk of adverse reactions at the age of under 10 years is still very high.
If the drug was prescribed by an experienced doctor, monitoring such reactions will be his responsibility, and at the slightest complications the medication is discontinued. This explains why giving Adaptol to children without a doctor’s prescription is unacceptable.

How to replace Adaptol?

If you have contraindications to Adaptol for VSD or this remedy is not suitable for you, you should try the antidepressant Cipralex.

Full-fledged analogues of Adaptol are:

Afobazol Lazeya Mebikar Stresam

Pharmacokinetics and pharmacodynamics

The bioavailability level is 80%. Once in the blood, the active substance is bound by red blood cells (40% of the dose received), the rest of it remains free in the plasma.

The highest concentration in the blood is observed 0.2 hours after oral administration, the same concentration is observed for 3-4 hours, after which the concentration begins to gradually decrease.

Excreted by the kidneys (most of it) and intestines. Does not accumulate in the body.

Storage conditions and shelf life

The place in which the package with Adaptal is located must be protected from sunlight and dry. The temperature in such a place should not exceed +25°C. The shelf life of the medicine is 4 years.

During pregnancy and lactation

The active ingredient of the drug easily penetrates all tissues of the body. There are no clear results of clinical studies of the effect of Adaptol on expectant mothers and nursing women . Therefore, using this remedy in this case is not recommended.

special instructions

The patient does not develop an addiction to the medicine, and no withdrawal syndrome is observed. During treatment, you can drive and perform activities that require increased attention. However, you need to be careful.