Picamilon is a nootropic drug with psychostimulant, antioxidant, tranquilizing and antiplatelet effects. Instructions for use explain how to properly take 20 mg and 50 mg tablets, injections in injection ampoules for the treatment of stroke and encephalopathy. What else does Picamilon help with, information on prices, analogues and patient reviews will also be presented in the article.
Release form and composition
- White flat tablets in dark glass or white plastic jars. Packs of 30, 50 or 100 pieces.
- Solution for injection in ampoules, colorless and transparent. Ampoules of 200 ml (active ingredient – 20 ml).
In one tablet: 10 mg of N-nicotinoyl-gamma-aminobutyric acid sodium salt + excipients (talc, calcium stearate, starch).
One ml of solution contains 100 mg of N-nicotinoyl-gamma-aminobutyric acid sodium salt + excipients.
Pharmacological characteristics
A drug that improves the processes of nervous activity associated with the processes of perception, memorization and reproduction of information. In addition, Picamilon has a vasodilating and healing effect, and also reduces headaches and helps thin the blood and increase the resistance of nervous tissue to oxygen deficiency. Also, while taking the drug, the condition of patients suffering from speech disorders and coordination of movements improves.
Picamilon is completely absorbed within several tens of minutes, regardless of the route of administration. Able to easily penetrate all protective barriers of the body. Picamilon is excreted through the kidneys within an hour and a half after taking the last dose.
Pharmacological properties
The action of the active component is aimed at improving metabolism and blood flow in brain tissue and eliminating the symptoms of brain hypoxia.
Pharmacodynamics
The drug promotes vasodilation and has tranquilizing, psychostimulating, antiplatelet and antioxidant properties.
The use of the medication leads to positive changes in the patient’s condition:
- the process of blood circulation in the brain is normalized;
- metabolic processes are enhanced;
- vascular tone decreases;
- the decomposition of glucose is activated;
- blood sugar levels decrease;
- endurance and ability for mental activity increases;
- memory improves;
- sleep patterns are normalized;
- thrombus aggregation is suppressed;
- the blood circulation process in the retina and optic nerve is activated.
Taking the drug can improve motor and speech functions, relieve anxiety and fear, reduce irritability and reduce the effect of ethanol on the central nervous system.
Pharmacokinetics
The active substance is completely absorbed. Penetrating the blood-brain barrier, it is retained in the tissues for a long time. Bioavailability reaches almost 90%. It is excreted unchanged from the body via the kidneys.
Indications for use
Why is Picamilon prescribed? According to the instructions, the drug is prescribed in the following cases:
- Asthenic conditions as a consequence of neuropsychic diseases;
- Cerebrovascular accidents (acute ischemic disorders, subacute and recovery periods of ischemic stroke, chronic cerebral circulatory failure);
- Neuroinfections, traumatic brain injuries (as one of the components of complex therapy);
- Conditions accompanied by fear, increased irritability, anxiety and/or emotional lability;
- Migraine prevention;
- Open-angle glaucoma (to stabilize visual function);
- Senile psychosis, as well as asthenia, vegetative-vascular dystonia, depression or other depressive disorders in elderly patients;
- Treatment of chronic alcoholism (the purpose of use is to reduce alcoholic encephalopathy, asthenoneurotic, asthenic, pre-relapse and post-psychotic conditions);
- Relief of acute alcohol intoxication (as part of combination therapy);
- Improving tolerance to physical and/or mental stress (for people in extreme or stressful conditions, as well as athletes);
- Urinary disorders in adults and children over 3 years of age (to reduce detrusor hypoxia and improve the adaptive function of the bladder).
Picamilon 20mg No. 30 tablets
Tablets are white or white with a slight creamy tint, flat-cylindrical, with a bevel.
| 1 tab. | |
| N-nicotinoyl-gamma-aminobutyric acid sodium salt | 20 mg |
Excipients:
potato starch, magnesium hydroxycarbonate hydrate (basic magnesium carbonate), sucrose, calcium stearate or stearic acid, talc. 30 pcs. - dark glass jars (1) - cardboard packs.
Clinical and pharmacological group:
Nootropic drug
Pharmacotherapeutic group:
Nootropic drug
pharmachologic effect
Nootropic drug, dilates blood vessels in the brain. It also has a tranquilizing, psychostimulating, antiplatelet and antioxidant effect. Improves the functional state of the brain by normalizing tissue metabolism and influencing cerebral circulation (increases the volumetric and linear velocity of cerebral blood flow, reduces cerebral vascular resistance, suppresses platelet aggregation, improves microcirculation). When taken as a course, it increases physical and mental performance, reduces headaches, improves memory, and normalizes sleep; helps reduce or eliminate feelings of anxiety, tension, fear; improves the condition of patients with motor and speech disorders.
Pharmacokinetics
Absorption is fast and complete, regardless of the route of administration. Penetrates through the BBB and is retained in body tissues for a long time. Bioavailability - 50-88%. It is excreted mainly by the kidneys unchanged. T1/2- 0.51 hours.
Indications
Cerebrovascular insufficiency, asthenia, depressive disorders in old age.
Conditions accompanied by anxiety, fear, increased irritability, emotional lability. Asthenic conditions caused by various neuropsychiatric diseases. As part of complex treatment - to relieve acute alcohol intoxication; in chronic alcoholism - to reduce asthenic, asthenoneurotic, postpsychotic, pre-relapse conditions, as well as alcoholic encephalopathy. Complex therapy includes migraine (prevention), head injury, and neuroinfection.
Improving the tolerance of physical and mental stress (for persons under intense and extreme conditions of activity; to restore the physical performance of athletes, to increase resistance to physical and mental stress).
Open-angle glaucoma (to stabilize visual function). In urological practice (in children over 3 years of age and in adults with urinary disorders) to improve the adaptive function of the bladder (reducing detrusor hypoxia).
Dosage regimen
Take orally, regardless of food intake. For cerebrovascular diseases, a single dose is 20-50 mg 2-3 times a day, a daily dose is 60-150 mg. The course of treatment is 1-2 months. Repeated course - after 5-6 months. Depressive states of late age: 40-200 mg/day for 2-3 doses, the optimal dose range is 60-120 mg/day for 1.5-3 months. As an antiasthenic and anxiolytic agent - 40-80 mg/day, if necessary - up to 200-300 mg/day, for 1-1.5 months. For alcoholism during the abstinence period, a dose of 100-150 mg/day is prescribed, for a short course of 6-7 days; for more persistent disorders outside of abstinence - 40-60 mg/day for 4-5 weeks. To restore performance and under increased loads - 60-80 mg/day for 1-1.5 months, for athletes at the same dose for 2 weeks. training period. Parenterally administered intravenously, drip or stream (slowly), intramuscularly. For chronic cerebrovascular accidents - IV or IM, 100-200 mg, 1-2 times a day, daily dose - 20-40 mg. Depending on the patient’s condition, it is used intravenously in the morning and intramuscularly in the evening; or within 10 days intravenously, then intramuscularly. The course of treatment is 15-30 days. To relieve acute uncomplicated ethanol intoxication, as part of complex therapy, a saturating dose of 5 mg/kg and a maintenance dose of 1.56 mg/kg/h in a volume of 2.5 liters of infusion solution are administered for 4 hours, morning and evening. For asthenic conditions, depending on the severity of the disease, in addition to oral administration, a daily dose of 20-40 mg is administered intramuscularly for 1 month.
Side effect
From the central nervous system: irritability, agitation, anxiety, dizziness, headache. Allergic reactions: skin rash, itching. Other: nausea.
Contraindications for use
Chronic renal failure, pregnancy, lactation, hypersensitivity to nicotinoyl gamma-aminobutyric acid.
Use during pregnancy and breastfeeding
Contraindicated for use during pregnancy and lactation (breastfeeding).
Use for renal impairment
Contraindicated in chronic renal failure.
Drug interactions
Reduces the duration of action of barbiturates. Enhances the effect of narcotic analgesics.
Instructions for use
According to the instructions for use, Picamilon tablets are taken orally, regardless of meals. Recommended doses and duration of treatment:
For cerebrovascular pathologies, the dose is 20-50 mg 2-3 times/day. The daily dose is 60-150 mg. The duration of Picamilon therapy is 1-2 months. It is recommended to repeat the course of therapy after six months.
At increased loads, as well as to restore performance, the drug Picamilon is used in a daily dose of 60-80 mg. The duration of use of the drug is 1-1.5 months.
Use for alcoholism. During the abstinence period, Picamilon is used in a short course (6-7 days) in doses of 100-150 mg/day. Outside of abstinence, for more persistent disorders, it is used in a daily dose of 40-60 mg for 4-5 weeks.
Read also: Why is Atarax prescribed? Instructions for medical use
Instructions for Picamilon injections
For parenteral use, the solution is administered intravenously in a stream or drip, as well as intramuscularly.
As part of combination therapy for the treatment of acute uncomplicated alcohol intoxication, a saturating dose of 5 mg/kg and a maintenance dose of 1.56 mg/kg/h in an amount of 2.5 liters of infusion solution are prescribed for 4 hours, twice a day (morning and evening).
For the treatment of chronic cerebral circulatory disorders, the drug is administered intramuscularly or intravenously 1-2 times a day, 100-200 mg - it can be prescribed in the morning as an intravenous infusion, and in the evening intramuscularly, or 10 days of intravenous infusions are carried out , then 10 days of intramuscular injection. The course of therapy is 15-30 days.
Overdose symptoms
If the daily doses recommended by the treating doctor are exceeded, overdose symptoms may occur. This:
- redness and itching of the skin;
- attacks of nausea ending with emptying the stomach (vomiting);
- headaches up to the development of migraines.
In case of such a development of the situation, symptomatic therapy is prescribed.
How does the drug interact with other medications?
It is not recommended to combine the drug simultaneously with drugs of the opioid group, since Picamilon enhances the effect of using the latter.
A tranquilizer can reduce the therapeutic effect of taking barbiturates.
Analogs
Complete analogues:
- N-nicotinoyl-gamma-aminobutyric acid sodium salt;
- Amylonosar;
- Sodium salt of N-nicotinoyl gamma-aminobutyric acid;
- Nicotinoyl gamma-aminobutyric acid;
- Picamilon solution for injection;
- picanoyl;
- PikogaM.
The most common analogues are: Aminalon, Bitopil, Bifren, Lucetam, Neurovin, Neuro-Norm, Nootropil, Noofen, Piracetam, Soakson, Phenibut, Phenotropil, Cerebrolysin.
When choosing analogues, it is important to understand that the instructions for use of Picamilon, price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.
Prescription of Picamilon for children
Instructions for use completely prohibit the use of the drug in children of primary preschool and school age, i.e. Officially, the drug should not be prescribed to children until they are 12 years old. But in some cases, a tranquilizer is used from the age of three.
The drug regimen will be as follows:
- For children aged 3...10 years, the permissible daily intake of the drug is no more than 0.04 grams. It needs to be divided into two.
- Children over 10 years old - 0.06 grams, divided into three doses.
The total duration of use is one...two months.
What do the reviews say?
Reviews from doctors: Doctors speak well of the drug. But they insist that the medicine greatly affects blood circulation and metabolic processes in the brain, so it should not be used without a doctor’s prescription.
Reviews about use by children: Despite the fact that the drug is not recommended for children under 3 years of age, many doctors prescribe it for young children from 2 years of age. The medicine does not cause allergies, there are practically no side effects. Parents are happy, children become calmer, and sleep returns to normal. For some, taking Picamilon stimulates speech development.
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Possible side effects
Most often, the product is absorbed by the human body without problems. But sometimes undesirable symptoms may form:
- allergic reaction (basically the appearance of a rash without itching);
- attacks of headache;
- increased irritability;
- attacks of nausea.
If side symptoms bother you very much, then you should stop using the drug and consult a leading doctor.
