Sidnocarb: instructions for use, reviews, price

Mesocarb
(lat. Mesocarbum, trade name: “Sidnocarb”, active ingredient: N-Phenylcarbamoyl-3-(β-phenylisopropyl)-sydnonimine) is a drug from the group of psychostimulants. White crystalline powder with a yellowish-greenish tint. Practically insoluble in water, sparingly soluble in alcohol.

General information[ | ]

Mesocarb is a psychostimulant created in the USSR in 1971 by M. D. Mashkovsky, and pharmacologists and psychiatrists Yu. A. Aleksandrovsky, G. Ya. Avrutsky, A. B. Smulevich took part in its clinical study [1]. In Western countries it is practically unknown. In terms of its chemical structure, it has some similarities with amphetamine, since it contains a phenylisopropyl radical; at the same time, it differs significantly from amphetamine in that it does not have a free amino group; The nitrogen atom, corresponding to the nitrogen of the amino group of amphetamine, is in mesocarb part of the heterocyclic system - sydnonimine, substituted in the amino group by a phenylcarbamoyl radical.

The chemical structure of mesocarb is close to feprosidnine.

The drug was produced by Russian. Currently not produced.

Mesocarb has long been the main psychostimulant used in Russian medical practice. It was believed that, compared to amphetamine, it is significantly less toxic and does not have a pronounced peripheral sympathomimetic effect[2]. Its stimulating effect develops gradually (there is no sharp initial activating effect), compared with amphetamine it lasts longer and is usually not accompanied by pronounced euphoria and motor excitement [2]. Although the drug does not improve mood, it nevertheless gives a feeling of a surge of energy, a state of vivacity, and increases performance [3]. The stimulating effect is usually not accompanied by tachycardia, a sharp increase in blood pressure and other peripheral sympathomimetic effects[2]. In the aftereffect period, there is no general weakness or drowsiness[2].

Pharmacological properties and mechanism of action

The drug Sidnocarb has a psychostimulating effect on the central nervous system with a pronounced effect. The drug does not cause addiction when used. When using it, there are no obvious signs of peripheral sympathomimetic activity. After using the medication, no clear symptoms of tachycardia occur.

In terms of its chemical structure, this drug is similar to another psychostimulant component - phenamine. However, Sidnocarb has a slight difference; it does not have a free amino group.

Sidnocarb is a psychostimulant that has a low level of toxic properties. It also has a gradual development of stimulating effects and a fairly long-lasting effect. While using the medication, there is no onset of a feeling of euphoria and motor activity.

The active component is absorbed quite quickly in the gastrointestinal tract. The body undergoes a process of biotransformation of the active constituent substance.

The largest part, almost 60% of the drug, is excreted by the kidneys. About 30% of the active component of the drug is excreted through the intestines. Another 10% comes out with air when exhaled. Does not have cumulative properties.

Mechanism of action[ | ]

According to the neurochemical mechanism of action, mesocarb differs from amphetamine. Experimental data show that mesocarb has a stronger effect on noradrenergic than on dopaminergic brain structures, while amphetamine has a stronger dopaminergic effect[2]. It is possible that mesocarb also differs from amphetamine in the activity of releasing catecholamines from various neuronal depots. It can be assumed that these neurochemical features of the action of mesocarb to some extent determine the differences in the clinical effectiveness and tolerability of mesocarb compared to amphetamine[2]. Mesocarb, along with its effect on the synaptic uptake systems of norepinephrine, also enhances the biosynthesis of dopamine from tyrosine [5].

Cases of overdose and side effects

In case of an overdose of mesocarb, the following symptoms may appear:

• feeling drowsy;
• weakness;
• state of lethargy;
• sleep disturbance, namely insomnia;
• blood pressure may increase;
• decreased or complete lack of appetite.

If these symptoms appear, you should stop using the drug and consult a doctor.

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When using the medication Sidnocarb, side effects occur in rare cases. Sometimes the following negative manifestations may appear:

• state of insomnia;
• the appearance of headaches;
• deterioration of appetite or its complete absence;
• Blood pressure levels may increase;
• the appearance of allergic reactions;
• feeling of restlessness, anxiety.

Application[ | ]

Mesocarb was used for various types of asthenic conditions, occurring with lethargy, lethargy, apathy, decreased performance, hypochondria, and increased drowsiness [2]. It is effective in the treatment of stuporous, sub-stuporous conditions, asthenic and neurasthenic disorders in patients who have suffered intoxication, infections and brain injuries; in some schizophrenias with a predominance of asthenic disorders (in the absence of productive symptoms)[2]; with apato-abulic syndrome in schizophrenia and narcolepsy [6]. Mesocarb can also be used to artificially aggravate the schizophrenic process in order to overcome the state of resistance to therapy with psychotropic drugs[3][2].

Mesocarb is an effective remedy that relieves asthenic phenomena that occur when using antipsychotic drugs [2]. It is an effective corrector that reduces or removes side effects (muscle relaxation, drowsiness) caused by benzodiazepine tranquilizers (phenazepam, etc.)[2][7]; however, it does not reduce the tranquilizing effect. The optimal dose ratio of phenazepam and mesocarb is 1:1.25 or 1:2.5 (at higher doses of mesocarb 1:5, night sleep disturbance may occur)[2]. Mesocarb can be prescribed simultaneously with phenazepam or in case of already developed side effects[2]. Preliminary application of mesocarb is less effective[2].

Mesocarb can be recommended for the treatment of patients with alcoholism with a predominant clinical picture of lethargy, lethargy, as well as asthenoneurotic reactions during the period of “alcohol withdrawal”, with alcoholic depression with adynamic symptoms [2]. Given the stimulating effect of mesocarb, it can be used to reduce withdrawal symptoms [2].

In combination with antidepressants, it was used to treat depression with apathy and lethargy[3].

Mesocarb is also effective in children with mental retardation, adynamia, spontaneity, organic diseases of the central nervous system with a predominance of lethargy, lethargy, and asthenia in the clinical picture [2]. Significant effectiveness of mesocarb in the treatment of hyperdynamic syndrome in young children has been noted[8][2].

The drug is also effective for bedwetting[6][2].

Mesocarb is usually well tolerated. In case of an overdose, increased irritability and anxiety are possible. An increase in delusions and hallucinations is possible in patients with previously existing productive psychopathological symptoms. Sometimes there is a decrease in appetite. A moderate increase in blood pressure is possible. Side effects disappear when the dose is reduced or the drug is temporarily stopped.

Due to its high efficiency and good tolerability, mesocarb has almost completely replaced amphetamine.

Mesocarb should not be prescribed to excited patients or with symptoms of irritable weakness. Caution is required in cases of pronounced atherosclerosis and severe forms of hypertension. To avoid disruption of night sleep, you should not take the drug in the evening.

Given the strong stimulating effect of mesocarb, it should be prescribed strictly according to indications, not for too long.

Instructions for use and what is Sidnocarb?

"Sidnocarb" is a stimulating drug whose action is aimed at the central nervous system. Before buying the drug at a pharmacy, you must consult a doctor, as a prescription is required. The product differs from analogues in its low level of toxicity, mild action and long duration of action. The instructions state that Sidnocarb is produced in the form of tablets containing 5, 10 or 25 mg of the treatment component. The healing substance is mesocarb, a substance that is quickly absorbed by the abdominal organs. In addition to the healing substance, the composition includes magnesium stearate and titanium dioxide.

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The product is intended for oral administration. It is recommended to take the tablets in the morning before the first meal, up to 2 times a day. The maintenance dosage is 5-10 mg/day. It is worth noting the peculiarities of dosage prescription, which are noted in the table:

Combinations[ | ]

Sydnoglutonum _

) was a combined preparation containing 0.025 g of mesocarb and 0.1 g of glutamic acid. Glutamic acid, as a mediator amino acid that stimulates central neurotransmitter processes, enhances the psychostimulating effect of mesocarb. Sidnogluton was prescribed to adults orally to improve physical and mental performance.

A promising corrector for mesocarb, complementing the range of its pharmacological properties, is adamantyl bromphenylamine (ladasten)[9]. A pharmacokinetic study in rats showed that mesocarb, when combined with adamantylbromophenylamine, is recorded in the blood plasma for a longer time, and higher values ​​of distribution coefficients in the tissues and organs of mesocarb are also recorded [9].

Directions for use and dosage

Sidnocarb should be taken orally before meals in the first half of the day.

Doses for each patient are selected individually. The recommended starting dose is 5 mg. If necessary, it is gradually increased to 15-25-50 mg per day. The average maintenance daily dose is 5-10 mg.

The maximum permissible doses for adults: single - 75 mg, daily - 150 mg, for patients with lucid catatonia it can be increased to 125-150 mg / day.

For elderly people, debilitated patients and children, Sidnocarb is prescribed at a dose of 2.5-5 mg in 2 doses.

Indications for use

Sidnocarb is prescribed to patients in the following cases:

• manifestation of an asthenic state due to mental and physical fatigue;
• consequences of severe traumatic brain injuries and serious illnesses;
• neurotic disorders in which inhibition is manifested;
• low-grade schizophrenia ;
• hypochondriacal syndrome, drowsiness ;
• apatoabulic, stuporous states;
• artificial exacerbation of schizophrenic processes;
• asthenia caused by taking antipsychotics and tranquilizers.

The drug is also prescribed to correct side effects that occur when taking benzodiazepine anxiolytics.

It is used in the treatment of alcoholism , withdrawal syndrome, adynamic depression, and mental retardation in children.

Reviews about Sidnokarb

Reviews from those who have taken this drug indicate that the drug can effectively relieve the unpleasant symptoms that appear when taking some antipsychotics.

There are also reviews about the effectiveness of tablets in the treatment of asthenic conditions, alcohol addiction, etc. At the same time, experts say that self-medication with the drug can lead to unpleasant consequences and side effects.

It is important not to use this medicine for a long time.