Description, composition, form of the medicinal product
In what form is the drug “Nitsergoline” produced? The instructions say that this product can be purchased in two forms:
- Lyophilisate in glass ampoules (that is, odorless white powder), packaged in PVC contour cells and cardboard boxes, respectively, together with a solvent (0.9% sodium chloride) intended for the preparation of an injection solution.
What does this product contain? It contains nicergoline, as well as milk sugar and tartaric acid.
- Biconvex tablets with a white film coating, packaged in blisters.
What components does this form of the drug “Nicergoline” include? In addition to the active ingredient of the same name, the tablets contain the following substances: potato starch, basic magnesium carbonate, milk sugar, povidone, stearic acid and magnesium stearate.
As for the white shell, it consists of basic magnesium carbonate, sucrose, colloidal silicon dioxide, beeswax, povidone, titanium dioxide, medical gelatin and talc.
Nicergoline: composition, form of entry into the pharmaceutical market, manufacturer
The drug Nicergoline appeared on the market in several forms:
- Tablet form (white color). The substance that encourages active action is nicergoline. One pack contains 10, 20 or 30 10 mg tablets.
- Lyophilisate (to create a solution for injection). It is a white powder in ampoules. The dosage of powder in 1 ampoule is 4 mg, the solvent in an ampoule is 5 ml. One pack of medication contains 5 ampoules of solvent and powder.
- Dragee. One pack contains 25 tablets of 10 mg each.
Manufacturer: Nitsergoline – Moskhimfarmpreparaty, Russian Federation.
Pharmacodynamic features of the drug: characteristics
The drug in question has a vasodilating effect (that is, it affects the arteries of the brain), and also belongs to the group of alpha-blockers.
The drug "Nitsergolin-LF", reviews of which are presented below, is a synthetic derivative of an alpha-adrenergic blocker and ergot alkaloids. The chemical formula of this product contains residues of bromo-substituted nicotinic acid.
The active component of the drug, as well as the ergoline derivative, contribute to a positive effect on the hemodynamic and metabolic processes that occur in the human brain.
Due to the fact that the drug in question has an alpha1-adrenergic blocking effect, its use increases the speed of blood flow in the lungs, brain and limbs, and also reduces platelet aggregation in the blood and improves its hemorheological parameters. This medicinal compound also exhibits antispasmodic properties and at the same time has a myotropic effect on vascular muscles, increases glucose permeability and equalizes the effect of the ergoline ring.
Nicergoline and Sermion, which is better?
Nicergoline and Sermion are complete analogues and synonyms in their composition and can successfully replace each other.
Unlike Nicergoline, Sermion is available in several dosages: 5 mg, 10 mg and 30 mg. The lyophilisate for creating the solution is available in ampoules of 4 mg. The 5 mg dose comes in orange tablet form. A dose of 10 mg is white tablets, a dose of 30 mg is yellow.
One pack (5 mg) contains 2 blisters of 15 tablets, 10 mg - 2 blisters of 25 tablets, 30 mg - 2 blisters of 15 tablets. The cost of Sermion (10 mg, 50 tablets) starts from 460 rubles to 590 rubles per pack. There are differences between the drugs in price and duration of use.
Since medications are analogous in their effects on the body, the patient’s choice will be influenced by the degree of availability and cost.
Main properties of the medicine
What is remarkable about such a remedy as “Nicergoline”? Reviews from experts claim that this medication reduces vascular tone and saturates the arterial blood flow with oxygen and glucose. It also has a beneficial effect on blood pressure, which can gradually normalize in case of hypertension.
It should also be noted that the medicine in question helps to improve hemorheological parameters, as well as reduce platelet aggregation and increase blood circulation in arteriopathy.
Analogues of the drug Nicergoline
Analogues are determined by structure:
- Sermion.
- Nilogrin.
- Nicergoline Deco, Ferein.
The group of angioprotectors and microcirculation correctors includes analogues:
- Tanakan.
- Asniton.
- Emoxipin.
- Pentohexal.
- Flexital.
- Vazaprostan.
- Dipyridamole.
- Agapurin.
- Pentoxifylline.
- Oxybral.
- Trental.
- Ginkor fort.
- Escisan.
- Betaserk.
- Etamzilat.
- Ascorutin.
- Phlebodia 600.
- Bilobil.
- Bilobil forte.
- Detralex.
- Phlebofa.
- Venen.
- Venarus.
- Rutin.
- Methylethylpyridinol.
- Betaver.
- Arbiflex.
- Actovegin.
- Dicynone.
- Vestibo.
- Tagista.
- Antistax.
- Angiovitis.
- Troxerutin.
- Aescusan.
- Ginkgo biloba.
- Westicap.
- Betahistine.
- Memoplant.
- Xanthinol nicotinate.
- Aescin.
- Chimes.
- Vasocket.
- A nicotinic acid.
- Troxevasin.
- Pentilin.
- Diosmin.
- Solcoseryl.
Pharmacokinetics of the drug
The drug "Nicergoline", reviews of which are mostly positive, reaches its maximum concentration in the blood 90 minutes after the first use. The bioavailability of this product is about 60%.
From the patient’s body, 80% of the medication is excreted through the kidneys (with urine), and 20% is excreted with feces.
Compound
One ampoule contains Nicergoline ( lyophilisate
, i.e.
composition for the preparation of a solution intended for intramuscular injection) contains 4 mg. nicergoline
(the active drug compound), as well as excipients such as
milk sugar (lactolose monohydrate) and tartaric acid.
One tablet of the drug contains 10 mg. active substance, as well as potato starch, milk sugar, basic magnesium carbonate, stearic acid, povidone and magnesium stearate.
The shell of the tablet form of the drug contains compounds such as basic magnesium carbonate, colloidal silicon dioxide (aerosil), sucrose, povidone, beeswax, titanium dioxide, talc and medical gelatin.
Indications for use
When are patients prescribed the drug "Nicergoline"? Reviews (tablets and injections with this name are sold in all pharmacies) say that the main indications for the use of this medicine are the following conditions:
- migraine;
- disturbances in the functioning of metabolic cerebral vessels of a chronic or acute nature caused by atherosclerosis, hypertension, ischemic attack, embolism, vasospasm, thrombosis or vascular dementia;
- Raynaud's disease;
- vertigo;
- diabetic angiopathy;
- circulatory disorders (peripheral);
- diabetic retinopathy;
- endarteritis;
- optic neuropathy;
- arteriopathy of the extremities;
- corneal diseases.
Nicergoline: reason for use
The primary reason for using Nicergoline is high blood pressure and identified hypertension. The medication helps in the treatment and relief of symptoms of the following diseases:
- Cerebrovascular disorders (all types of diseases attributed to these disorders);
- Hypertension, arterial hypertension;
- Vascular diseases of the extremities;
- Disorders of the blood vessels of the circulatory system;
- Severe migraine and some other diseases.
Contraindications for use
What patient conditions prohibit the use of the drug "Nicergoline"? Reviews (injections and tablets have the same contraindications) speak of the following prohibitions:
- hypersensitivity;
- galactose intolerance;
- previous heart attack;
- hypotension;
- pregnancy;
- bradycardia;
- minor age;
- breast-feeding;
- glucose-galactose malabsorption;
- lack of lactose.
This medicine should be used with caution by people with gout, hyperuricemia, and also in combination with drugs that affect the metabolism and excretion of uric acid from the body.
Contraindications
Ergot alkaloids are a naturally occurring substance that can cause an allergic reaction. The drug should not be used if you are intolerant to the main active ingredient or formative components. It is important to remember that the tablets contain lactose, so they should not be prescribed to people whose bodies cannot tolerate this substance.
Among other contraindications:
- recent myocardial infarction;
- acute bleeding;
- severe bradycardia;
- hypotension;
- childhood.
The drug should not be taken by people with low blood pressure, including orthostatic hypotension. In this case, there is a high risk of developing severe side effects associated with a decrease in vascular tone.
The drug should not be taken by children under 18 years of age and nursing women. If treatment with Nicergoline is necessary during lactation, the child must be switched to formula feeding.
Side effects of Nicergoline include a decrease in blood pressure, so it should not be used if you have hypotension.
Medication "Nitsergolin": instructions for use
Reviews from doctors claim that this remedy must be taken in strictly recommended dosages. As a rule, Nicergoline tablets are prescribed three times a day before meals or during meals at a dose of 5-10 mg.
The duration of treatment with this medicine is usually 3 weeks. But if necessary, this period can be extended to several months.
Before use, Nicergoline lyophilisate should be diluted with a solvent (sodium chloride) and then administered intramuscularly (2-4 mg twice a day). The duration of therapy and the dosage of this drug depend on the severity and nature of the disease, as well as on the condition of the patient.
For people with impaired kidney function, the drug in question is recommended to be used in the smallest possible quantities.
Description and instructions for the drug Nicergoline
Nicergoline is a drug with a vasodilator effect.
Pharmacologically, it is an alpha 1-adrenergic blocker. Thanks to the active substance of the same name, Nicergoline improves blood flow in the extremities and brain. The patient's blood becomes more fluid and less prone to forming clots. Since organs and tissues are more intensively washed with blood, the metabolism in them is accordingly normalized. If the patient suffers from hypertension, treatment with Nicergoline can reduce blood pressure - this effect develops gradually. An analogue of this medicine is Sermion. Nicergoline is used for:
- Vascular and metabolic disorders of the brain - migraines, thrombosis, dementia and so on;
- Vascular and metabolic disorders associated with damage to the peripheral blood flow - angiopathy of the extremities, for example;
- Maintaining therapy for hypertension.
Nicergoline is produced in tablets and in powder form for the preparation of an injection solution. Separate ampoules contain saline solution for diluting the medicine. Nicergoline is administered intramuscularly. The instructions for the drug do not say anything about the duration of the course of treatment - it may vary depending on the patient’s condition.
Nicergoline is contraindicated for:
- Tendency to bleed;
- Recent myocardial infarction;
- Severe bradycardia;
- Low pressure;
- Disorders of carbohydrate metabolism - lactose and galactose;
- Pregnancy, lactation and patients under eighteen years of age.
- carefully -
- For gout and uric acid metabolism disorders.
Side effects and overdose of Nicergoline
Therapy with this vasodilator drug can significantly reduce blood pressure, cause dizziness, and hot flashes. In addition, patients sometimes experienced digestive disorders and sleep disorders - both drowsiness and insomnia. At any stage of treatment and regardless of the dose of Nicergoline, an increase in the level of uric acid in the blood is possible. This makes it necessary to periodically monitor blood biochemistry in patients receiving this drug.
In case of overdose, any of the above undesirable effects may appear or intensify. Depending on the observed symptoms, treatment is prescribed.
Side effects after using the medicine
Side effects are prescribed in the instructions for the drug "Nicergoline". Consumer reviews report that during the use of the drug in question they often experienced such adverse reactions as:
- nausea, decreased blood pressure, drowsiness;
- abdominal pain, allergic reaction, dizziness;
- fever, diarrhea, increased uric acid levels, insomnia.
"Nitsergoline" tablets
The instructions indicate that the pills should be taken at a dosage of 10 mg 3 times a day, maintaining equal intervals between doses. Typically, therapy is long-term, several months.
The dosage and duration of their use is determined based on the nature, severity of the disease and the effectiveness of the therapy. Sometimes it is better to start treatment with injections and then gradually switch to oral administration.
For the treatment of vascular dementia, 30 mg is prescribed 2 times a day. In this case, every 6 months a doctor’s consultation is required regarding the advisability of continuing therapy. In case of functional renal impairment, it is recommended to reduce the therapeutic dosage of the drug.
For migraine, the drug is prescribed as a prophylaxis. It can be taken both as a course and in special cases when a person feels the onset of an attack.
For hypertension, the drug dosage regimen is somewhat different. Doctors often prescribe 1 tablet per day to minimize the negative impact of high blood pressure on the cerebral circulatory system.
The instructions for Nicergoline indicate that at the beginning of therapy, intramuscular or intravenous administration of the drug can be prescribed, followed by a transition to taking tablets as maintenance therapy. It is very important to correctly calculate the dosage of the drug to minimize side effects.
Overdose, drug interactions
What symptoms occur when using large doses of the drug in question? Signs indicating an overdose are conditions such as orthostatic collapse, hypotension, and allergic reactions. In addition, if the dosage of the drug recommended by the doctor is exceeded, the severity of side effects in patients increases significantly.
According to the instructions, the drug "Nicergoline" can enhance the effectiveness of antipsychotic and antihypertensive drugs, as well as anxiolytics. It should be noted that antacids and cholestyramines reduce the absorption of this medication.
When the drug is used in parallel with adrenergic stimulants, patients may experience idiosyncrasy.
special instructions
According to the instructions, “Nicergoline” is completely incompatible with alcohol. Alcoholic drinks entering the body can increase or decrease blood pressure. When taking Nicergoline and alcohol simultaneously, the following body reactions are possible:
- headache;
- cardiopalmus;
- immediate increase or decrease in pressure.
In the first days of using the drug in patients with vascular atherosclerosis and hypertension, orthostatic hypotension may develop. This condition is characterized by a fairly sharp decrease in pressure that occurs when the body position changes.
Among the main symptoms of orthostatic hypotension are the following:
- weakness;
- dizziness;
- darkening of the eyes;
- a clear sensation of your own heartbeat.
In addition, there have been cases of increased uric acid concentrations when taking this drug. That is why people with gout need to use the medicine very carefully.
The drug is eliminated from the body through urine. In severe forms of renal impairment, it is recommended to reduce the dosage of the drug.
"Nicergoline" is taken over a long course. Its effectiveness should be assessed every 6 months. In the presence of hypertension, the duration of therapy can reach several years.
During treatment, it is recommended to refrain from driving vehicles, since the effect of the drug on reaction speed has not been studied.
The drug "Nitsergolin": reviews of patients and doctors, analogues
Analogues of this remedy are drugs such as “Nilogrin”, “Sermion” and “Nitsergolin-Fereig”.
The medication in question is strictly prohibited from being used in conjunction with narcotic drugs and alcoholic beverages.
To avoid the development of hypotension, including at the very beginning of therapy, after intramuscular administration of the drug solution, patients must remain in a horizontal position for some time.
It should also be noted that most doctors, during treatment with Nitsergoline, prohibit their patients from driving a vehicle, as well as from engaging in activities that require instant psychomotor reactions and increased concentration.
As for consumers, the majority of them leave negative reviews about the drug “Nitsergolin”. This is primarily due to the fact that patients very often encounter its side effects, and also do not notice any improvements or medicinal effect for a long time.
Practical application experience
Opinion of practicing doctors and reviews of patients who took Nicergoline.
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The drug is quite effective, side effects are rare. During the treatment process, I do not recommend engaging in work that requires intense attention and immediate psychomotor reactions.
Vasily Konstantinovich, neurologist
I started using this product in my practice not so long ago. Patients often complain of orthostatic hypertension (after IV administration). I do not prescribe this medication during pregnancy.
Antonina Stepanovna, neurologist
I took this remedy in an amount of 5 mg three times a day. Side effects began to appear immediately (chest and back pain). Significant changes were visible on the ECG, which indicates the side effects of adrenergic blockers.
Anna, 30
I am hypertensive, which causes me to have constant headaches. This medicine was prescribed to me by my therapist. But I didn’t take the pills as a course, but only when the pain bothered me. As a result, the pain went away, but I had terrible sweating (a rather strange side effect). Because of this, I stopped taking Nicergoline.
Nina, 59
From reviews of doctors and patients, it is clear that the drug does not always have the desired therapeutic effect, since many people interrupt the course of treatment due to the appearance of third-party reactions.
