In this article we will look at the side effects and reviews of the drug “Clopixol Depot”. It is a neuroleptic, antipsychotic drug. According to its chemical characteristics, it belongs to substances that are derivatives of thioxentane. When using Clopixol, a temporary, dose-dependent sedative and antipsychotic effect is observed.
The non-patented international name of the drug is zuclopenthixol. The active active ingredient in the drug is zuclopenthixol decanoate.
Release form of this drug
"Clopixol Depot" is produced in the form of an oily solution, which is intended for intramuscular administration. Packaged in colorless glass ampoules, each of which can contain 200, 500 mg of the active ingredient.
Each package of the drug with a dosage of 200 mg may contain 1 or 10 glass ampoules. The neck of the ampoule is marked with a break in the form of a red dot.
Each package of the drug with a dosage of 500 mg can contain 1 or 5 ampoules.
A package with one ampoule of Clopixol Depot costs an average of 445 rubles. A package containing 10 ampoules will cost approximately 3,000 rubles.
Forms of the drug, its composition, description, packaging
The product in question has different release forms. Let's introduce them right now.
1. "Clopixol" - pale pink, pinkish-brown and red-brown tablets (2 mg, 10 mg and 25 mg, respectively). They have a round and biconvex shape, as well as a film shell.
The active element of this product is zuclopenthixol dihydrochloride. It also contains 85% glycerol, potato starch, copovidone, lactose monohydrate, microcrystalline cellulose, talc, magnesium stearate, castor oil.
The medicine in question goes on sale in plastic containers and cardboard boxes.
2. Oil solution for intramuscular administration “Clopixol”. Reviews claim that this product is sold in ampoules made of colorless glass. The solution itself is yellowish in color and transparent. It is completely free of particles.
The active element of this medicine is zuclopenthixol decanoate. It also contains triglycerides.
Pharmacological characteristics of the drug
"Clopixol Depot" is an antipsychotic that belongs to the group of thioxanthene derivatives and has an antipsychotic effect.
The main pharmacological properties of the drug include a specific inhibitory and antipsychotic effect. In addition, Clopixol has a nonspecific sedative effect, which gradually weakens after several weeks of using the medication.
According to the instructions for Clopixol Depot, the therapeutic effect of the drug is due to the ability of the active component to block dopamine receptors located in the brain. Such a blockade, in turn, leads to a cascade reaction in which other mediator systems are also involved.
The most effective use is in patients with developing severe psychomotor agitation, agitation, outbursts of aggression, and anxiety.
Compared to the usual form of Clopixol, the effect of Clopixol Depot is prolonged. This feature of the drug allows it to be used continuously for the treatment of protracted and acute psychoses. This property is most relevant in the treatment of patients who refuse to take medications and have a negative attitude towards the recommendations of specialists.
With the introduction of "Clopixol Depot" the development of exacerbations and partial relapses of the disease is prevented. This type of use is significantly superior to the use of oral forms of the drug, which the patient is able to independently interrupt due to painful beliefs.
Conducted clinical and laboratory biochemical studies show that the most appropriate frequency of drug administration is a single use every 2-4 weeks.
When zuclopenthixol decanoate enters the body, under the influence of specific enzymes, it begins to break down into zuclopenthixol and decanoic acid.
Cost of the drug and reviews about it
The price of the medication in question depends on the form of its release. 2 mg tablets in an amount of 50 pieces cost about 250 rubles, 25 mg tablets (100 pieces) cost approximately 1,600 rubles, and 10 mg tablets (50 pieces) cost approximately 480 rubles.
As for the oil solution, its price reaches 2300 rubles.
Most often, consumer reviews of the drug "Clopixol" are left by those patients who have used this medication in the form of an injection solution. Such patients claim that the course of using this remedy is very convenient. This is due to the fact that injections should be done extremely rarely (unlike taking pills).
According to consumer reviews, the drug "Clopixol" is a very effective and fast-acting antipsychotic. But, unfortunately, it quite often causes side effects.
Clopixol is a drug classified as an antipsychotic. You should read the instructions for use of this drug.
What is the composition and release form of Clopixol?
The medicine is produced in different tablets, some of them are pale pink in color, their shape is round, they are biconvex. The active substance of the drug Clopixol is zuclopenthixol at a dose of 2 mg. Auxiliary components: talc, potato starch, magnesium stearate, lactose monohydrate, in addition, copovidone, microcrystalline cellulose, glycerol 85%, as well as hydrogenated castor oil.
The shell is formed by hypromellose 5, macrogol 6000 is present, in addition, titanium dioxide, as well as red iron oxide. The tablets are placed in plastic containers of 50 and 100 pieces.
The next type of Clopixol tablets is presented in pink-brown color, they are round, biconvex. The active compound of the drug is zuclopenthixol at a dose of 10 mg. Excipients are similar to those described above.
Another red-brown tablet is biconvex and round in shape. The active compound is zuclopenthixol in an amount of 25 milligrams. The medicine Clopixol is sold by prescription and must be stored at a temperature not exceeding 25 degrees. On the packaging of the medication you can see the expiration date of the antipsychotic.
What is the effect of the drug Clopixol?
The antipsychotic drug Clopixol is a thioxanthene derivative. The medicine has an antipsychotic effect, in addition, the sedative effect of this medication has been identified.
The drug is effective for agitation (motor agitation); an antipsychotic is prescribed for anxiety, hostility, and also for aggressiveness. After taking the medication orally, the maximum concentration of the active compound zuclopenthixol is achieved in the blood after approximately four hours.
Bioavailability - about 44%. When Clopixol tablets are taken orally, the half-life is 20 hours. Metabolites of the drug do not have so-called antipsychotic activity. The medicine is excreted in the urine and through the intestines.
What are the indications for use of the drug Clopixol?
The drug Clopixol is indicated for use in the following cases:
For schizophrenia and other psychotic disorders that occur with hallucinations, impaired thinking, as well as paranoid delusions; When agitated; An effective remedy for increased anxiety; With hostility and aggressiveness; A neuroleptic is prescribed for senile dementia; For manic-depressive psychosis occurring in the manic phase.
In addition, the antipsychotic is effective for mental retardation, which can be combined with motor agitation and other behavioral disorders.
What are the contraindications for use of Clopixol?
The drug Clopixol is not used for acute intoxication with alcohol, barbiturates, opioid analgesics; in addition, an antipsychotic is not prescribed for coma.
What are the uses and dosage of Clopixol?
The drug should be taken orally, and the doctor selects the dose individually, based on the clinical picture of the disease. At first, it is customary to prescribe low doses of the drug, which are then quickly increased to achieve the optimal therapeutic effect.
During an attack of schizophrenia, in addition, with severe motor agitation, the patient is prescribed a drug in an amount of 10 to 50 milligrams per day, adjusting the dosage of the drug depending on the patient’s condition.
Overdose from Clopixol
In case of an overdose of Clopixol, the instructions for use warn that hypotension, drowsiness, coma, extrapyramidal disorders, convulsions, shock, and changes in body temperature are possible. The patient's stomach should be rinsed as soon as possible, it is recommended to prescribe enterosorbents, and also carry out symptomatic therapy.
What are the side effects of Clopixol?
The neuroleptic drug causes the following side effects: extrapyramidal disorders, drowsiness, urinary retention is possible, accommodation disturbance is possible, the development of tardive dyskinesia is characteristic, it is mainly observed with prolonged treatment with this drug.
In addition, there are some other side effects: tachycardia is typical, dizziness is associated, and orthostatic hypotension is possible. Negative changes occur in the digestive tract, they are expressed by constipation, dry mouth is noted, laboratory tests can detect changes in liver tests.
If any of the listed side effects occur on the use of the drug Clopixol, the patient is advised to consult with a competent specialist in a timely manner, and the doctor will adjust the dose of the tablets.
special instructions
The neuroleptic Clopixol is prescribed with caution in cases of diagnosed chronic hepatitis, arrhythmia, or diagnosed convulsive syndrome. You should be aware that the use of the medication can lead to the development of NMS (neuroleptic malignant syndrome), even with death.
How to replace Clopixol, what analogues should I use?
The medicine Zuclopentixol, as well as Clopixol Depot, in addition, Clopixol-Acufaz, are analogues.
Conclusion
Antipsychotic medications should only be used after approval from a qualified doctor.
The patient must independently study the instructions for use of the prescribed drug. Be healthy!
Result: positive feedback
Get rid of hallucinations
Advantages: efficiency
Disadvantages: high cost, side effects
My wife has a serious mental illness that causes hallucinations. There are days when I can’t even persuade her to go to bed, because of the terrible pictures that her imagination draws. That's why products like Clopixol literally save the lives of people like her. It's an antipsychotic and when you take it, it doesn't come without side effects, but it really helps. Hallucinations stop and anxiety levels decrease. You have to pay for this with attacks of drowsiness and dizziness, but this is a small price to pay for such significant advantages. A large package of the drug is expensive - more than three thousand. There's nothing you can do about this either.
Result: neutral review
Relieves aggressive state
Benefits: no drowsiness, relieves aggression
Disadvantages: many contraindications and side effects
The first time I was given this injection in the hospital, the doctors had to tie me to the bed, as I was very aggressive, smashing everything around and fighting. The drug quickly brought me out of the aggressive state, but I felt stiffness throughout my whole body, it was difficult to move, and I had convulsions from time to time. But a huge plus is that it does not cause drowsiness, you feel alert. Three weeks after the injection, no stiffness appeared. I advise you to use the drug only under the supervision of your doctor, as it can have a strong effect on the body, even death.
Result: positive feedback
Advantages: quality, effectiveness
Disadvantages: side effects, price
Clopixol depot was prescribed to replace another antipsychotic, from which I had terrible side effects. I’ll say right away that the medicine is expensive, but it brought me out of a state of psychosis quickly and well. The drug is produced in tablets and injections. I was prescribed intramuscular injections. The medicine was administered slowly, and therefore there was no pain. But under the influence of Clopixol Depot it was very difficult for me, there were a lot of useful side effects, fortunately, the injections were not given every day. Even though the medicine caused me side effects, I was satisfied with its effect, because thanks to Clopixol Depot, the exacerbation of psychosis was blocked.
Result: positive feedback
Strong oil-based product.
Advantages: Strength and speed of action.
Flaws:
Clopixol depot is very strong due to the fact that it is made on an oil base. Oily liquids stay in the body much longer and have a prolonged effect. My husband was injected with it during psychosis, it worked quickly, but if the medicine is not quite suitable, it takes time to stop it working. We had minor side effects - body cramps. After about a week, the side effects went away, and Clopixol itself lasted for about two months. This is good if the drug is chosen correctly, but if it is not suitable, you need to immediately begin to flush it out of the body, and this can be difficult to do in psychotic disorders. In our case, Clopixol depot was almost ideal; we will repeat it if necessary; other medications were injected more often and in larger doses.
Antipsychotic drug (neuroleptic), thioxanthene derivative. Drug: CLOPIXOL Active substance of the drug:
zuclopenthixol ATC coding: N05AF05 KFG: Antipsychotic drug (neuroleptic) Registration number: P No. 014166/01-2002 Registration date: 06/24/02 Registration owner. cred.: H.LUNDBECK A/S {Denmark}
Release form of Clopixol, drug packaging and composition.
Tablets, coated, pale pink, round, biconvex.
1 tab.
2 mg
The tablets are pinkish-brown, round, biconvex.
1 tab. Zuclopenthixol (as dihydrochloride) 10 mg
Excipients: potato starch, lactose monohydrate, microcrystalline cellulose, copovidone, glycerol 85%, talc, hydrogenated castor oil, magnesium stearate.
50 pcs. - plastic containers. 100 pieces. - plastic containers.
Red-brown film-coated tablets, round, biconvex.
1 tab. Zuclopenthixol (as dihydrochloride) 25 mg
Excipients: potato starch, lactose monohydrate, microcrystalline cellulose, copovidone, glycerol 85%, talc, hydrogenated castor oil, magnesium stearate.
50 pcs. - plastic containers. 100 pieces. - plastic containers.
DESCRIPTION OF THE ACTIVE SUBSTANCE. All information provided is provided for information only about the drug; you should consult your doctor about the possibility of use.
Pharmacological action of Clopixol
Antipsychotic drug (neuroleptic), thioxanthene derivative. It is believed that the antipsychotic effect of zuclopenthixol is due to the blockade of dopamine receptors in the central nervous system. Thioxanthene derivatives have a high affinity for dopamine D1 and D2 receptors.
Zuclopenthixol causes rapid, transient, dose-dependent sedation before the development of antipsychotic action.
Unlike zuclopenthixol hydrochloride, zuclopenthixol acetate has a longer duration of action - 2-3 days, and zuclopenthixol decanoate is a depot form and its effect lasts for 2-4 weeks.
Pharmacokinetics of the drug.
After oral administration, zuclopenthixol is rapidly absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved after 3-6 hours. Biological T1/2 is about 24 hours.
After intramuscular administration in the form of a depot form, Cmax in blood plasma is reached after 36 hours. 3 days after injection, the level is approximately 1/3 of the maximum.
Zuclopenthixol is distributed throughout the body, with higher concentrations being created in the liver, lungs, intestines and kidneys, and lower concentrations in the heart, spleen, brain and blood.
Vd is 20 l/kg. Plasma protein binding 98%.
Penetrates the placental barrier and is excreted in breast milk.
Zuclopenthixol is metabolized by sulfonic acidification, N-dealkylation and glucuronidation. Metabolites do not have psychopharmacological activity.
It is excreted mainly in feces in the form of unchanged substance and N-dealkylated metabolite.
Indications for use:
For oral administration: manic phase of manic-depressive psychosis, mental retardation in combination with psychomotor agitation, agitation and other behavioral disorders; senile dementia with paranoid ideas, confusion, disorientation, behavioral disturbances.
For intramuscular administration: initial treatment of acute psychoses, manic states and chronic psychoses in the acute phase.
For intramuscular administration of the depot form: maintenance therapy for schizophrenia and paranoid psychoses.
Dosage and method of administration of the drug.
The dose, frequency and duration of use depend on the indication, dosage form used and treatment regimen.
For oral administration, the initial dose may be 2-20 mg/day; if necessary, a gradual increase in dose to 75 mg/day or more is possible.
For intramuscular administration, a single dose is 50-150 mg; if repeated injections are necessary, the interval between them should be 2-3 days.
For intramuscular administration of the depot form, a single dose is 200-750 mg, the frequency of administration is 1-4 weeks and is determined by the clinical situation.
Side effects of Clopixol:
From the side of the central nervous system: dizziness, drowsiness (especially when using the drug in high doses and at the beginning of treatment), development of extrapyramidal disorders (mainly at the beginning of treatment), disturbance of accommodation; rarely, with long-term therapy - tardive dyskinesia.
From the cardiovascular system: tachycardia, orthostatic hypotension.
From the digestive system: dry mouth, constipation, rarely - minor transient changes in liver tests.
From the urinary system: urinary retention.
Contraindications to the drug:
Acute overdose of barbiturates, opioid receptor agonists, acute alcohol intoxication, coma, hypersensitivity to zuclopenthixol.
Use during pregnancy and lactation.
Use during pregnancy and lactation is not recommended.
Zuclopenthixol is found in low concentrations in breast milk.
Special instructions for the use of Clopixol.
Zuclopenthixol is not used in patients intolerant to oral antipsychotics, as well as in patients with Parkinson's disease.
Use with extreme caution in patients with convulsive syndrome, chronic hepatitis and cardiovascular diseases.
With long-term use, careful monitoring of the patient's condition is necessary.
It should be borne in mind that when using antipsychotics, a rare but possible complication with a fatal outcome is the development of NMS. In such cases, you should immediately stop using antipsychotics and begin emergency symptomatic therapy.
During treatment with zuclopenthixol, antiparkinsonian drugs should be prescribed only if there are appropriate indications and should not be used prophylactically.
Zuclopenthixol acetate should not be used concomitantly with guanethidine and other drugs with a similar mechanism of action.
Impact on the ability to drive vehicles and operate machinery
During treatment with zuclopenthixol, especially at the beginning, it is necessary to avoid activities that require high concentration and rapid psychomotor reactions.
Highest level of drug concentration in the blood
As the instructions for Clopixol Depot indicate, the highest level of concentration of the active component in the patient’s blood is observed 7 days after administration. Half-elimination takes an average of 20 days. In small quantities, zuclopenthixol can penetrate the blood-brain barrier and accumulate in women's breast milk. Metabolites of the active component are not capable of producing a neuroleptic effect. Most of them are excreted through the intestines, a small amount - along with urine.
The pharmacological parameters of a single use of the drug in 14 days are identical to the oral use of the usual form of the drug, 25 mg orally once a day.
Indications for use of this medication
"Clopixol Depot" is indicated for use by patients suffering from the following conditions and diseases:
- Schizophrenia, which has a chronic or acute form.
- Acute psychotic disorders of a polymorphic nature, accompanied by schizophrenic symptoms.
- Inorganic psychoses, which are in chronic or acute form and are accompanied by the appearance of delusional experiences (paranoid or paranoid type), hallucinatory disorders.
- Mental retardation, characterized by severe behavioral disorders - aggression, increased anxiety, psychomotor agitation.
- Bipolar psychotic disorders, accompanied by aggression, delusional statements, agitation.
- Psychoses of a senile nature, having paranoid inclusions, accompanied by disorientation and confusion.
Directions for use and dosage
Clopixol should be taken orally; if necessary, the daily dose is divided into several doses.
The doctor selects the dose individually, based on the patient’s condition. At the beginning of therapy, it is recommended to take Clopixol in low doses. Depending on the patient's response to the treatment, the dose can be quickly increased until a clinical effect is achieved.
In the treatment of an acute attack of schizophrenia and other acute psychotic disorders, mania and severe agitation, the daily dose of Clopixol is usually 10-50 mg.
The maintenance dose for the treatment of chronic psychotic conditions in schizophrenia and other chronic psychoses is 20-40 mg per day.
For severe and moderate psychotic disorders, the initial daily dose is 20 mg. If necessary, it can be increased at intervals of 2-3 days by 10-20 mg up to 75 mg per day or more.
In the treatment of senile disorders accompanied by confusion and agitation, Clopixol is prescribed 2-6 mg per day with a possible increase in the need to 10-20 mg per day. It is preferable to take the drug in the evening.
In patients with oligophrenia and agitation, the daily dose is 6-20 mg, if necessary it can be increased to 25-40 mg.
Contraindications to the use of Clopixol Depot
The medication should not be prescribed to patients with the following pathological or physiological conditions:
- Individual susceptibility, hypersensitivity to the active or any auxiliary component present in the composition of the drug.
- Coma.
- Acute barbiturate poisoning.
- State of acute intoxication with opioid drugs.
- A state of acute alcohol intoxication.
It is undesirable to prescribe the medication during the lactation period and during pregnancy.
Use of this medicine
The oil solution must be injected intramuscularly as deep as possible into the gluteal tissue in the area of the upper outer quadrant. Reviews from patients and specialists indicate good local tolerability of the drug.
The frequency of administration for each patient should be determined individually, taking into account his condition:
- If maintenance therapy is necessary, up to 2 ml of Clopixol Depot is administered, having a dosage of 200 mg once every 14-28 days.
- In severe drug-resistant cases, the patient may require an increase in dosage or a reduction in the interval between drug administrations.
- If there is a need to use higher dosages, the use of the drug with a dosage of 500 mg is recommended.
- "Clopixol Depot", having a dosage of 500 mg, is indicated for administration once every 7-28 days in an amount of up to 1.5 ml.
- If it is necessary to transfer a patient from oral forms of the drug to intramuscular administration, a certain scheme should be followed. The daily dose of the oral drug must be increased 8 times and thus the required dose of the drug with a prolonged action must be calculated for 14 days. After the first intramuscular injection is administered, oral tablets must be taken for 7 days, while reducing their dose.
- In the case when a transition is made from the intramuscular form of a drug with a regular (non-extended) action, up to 2 ml of the drug with a prolonged action should be administered simultaneously with the last dose. Repeated injection is carried out after 1-2 weeks.
Instructions for use
Clopixol tablets are taken orally. The dosage of this drug is selected individually, depending on the patient’s condition. At the very beginning of therapy, the medication is prescribed in low doses, and then they are quickly increased until a clinical effect is achieved.
For severe and moderate cases, the initial dosage of Clopixol is 20 mg per day. If required, it can be increased by 20 mg.
For an acute attack of schizophrenia and other acute psychotic disorders, mania and severe agitation, the dosage of the drug is 10-50 mg per day.
For psychotic conditions of a chronic nature, as well as for schizophrenia and other psychoses, the maintenance dosage of the drug in question is 20-40 mg per day.
For agitation in people with mental retardation, the dose of the drug is 6-20 mg per day. If necessary, it can be increased to 25-40 mg per day.
For senile disorders with agitation and confusion, this medication is prescribed at a dose of 2-6 mg per day. If required, the indicated amount of the drug is increased to 10-20 mg per day.
Side effects of Clopixol Depot
During the use of the drug, the central nervous system, autonomic nervous system, and liver may respond with the development of negative symptoms:
- The central nervous system responds with the occurrence of extrapyramidal disorders. Such manifestations are especially noticeable in the initial stages of treatment; they can be eliminated by adjusting the dose and using specific corrective drugs from the group of antiparkinsonian medications. However, experts do not recommend using correctors for preventive purposes unless there is an urgent need for it. With long-term use of antipsychotic drugs, tardive dyskinesia may develop, which cannot be eliminated with antiparkinsonian drugs. In this case, it is advisable to reduce the dose or completely abandon (if possible) the use of antipsychotics. Also, at the initial stages of treatment, the patient may experience lethargy and drowsiness, and at later stages – depression.
- The VNS responds to the use of Clopixol Depot with orthostatic hypotension, dizziness, disturbance of accommodation, constipation, urinary retention, dry mouth.
- From the liver, the following negative responses are noted: changes in the level of liver transaminases and alkaline phosphatase.
If these negative effects occur while taking the drug, it is necessary to consult with a specialist and consider the possibility and advisability of replacing the drug with another one that has a similar therapeutic effect.
How to treat symptoms of overdose from this drug?
Overdose therapy involves prescribing supportive and symptomatic treatment. The patient must be admitted to the ICU (intensive care unit), where doctors take the necessary steps to maintain normal functioning of the heart and lungs. In case of an overdose, you should not administer adrenaline to the victim - this can provoke an even greater decrease in blood pressure. Diazepam allows you to stop convulsive syndrome. The instructions for use for Clopixol Depot confirm this.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Clopixol Depot, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Clopixol Depot is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Interaction of the drug with other medications
The drug has a potentiating effect in relation to all medications that can suppress the activity of the nervous system. With parallel use, the effect of narcotic analgesic drugs, antidepressants, antipsychotics, tranquilizers, barbiturates, sleeping pills, and ethyl alcohol increases.
When used simultaneously with guanethidine drugs, the antihypertensive properties of the latter are blocked.
When combining Clopixol Depot with metoclopramide and piperazine, the likelihood of developing extrapyramidal disorders increases.
Analogues of this drug
If necessary, "Clopixol Depot" can be replaced with one of its pharmacological or structural analogues. However, it is important to remember that all analogs are potent neuroleptics, have specific contraindications, and can provoke quite serious negative effects. That is why any replacement of the drug must be discussed with a doctor. Only a specialist will take into account all the nuances and determine the possibility and advisability of replacing the drug.
The most popular analogues are: “Clopixol acupaz”, “Clopixol”, “Moditen Depot”, “Haloperidol decanoate”. The last two drugs also have a prolonged effect.
Below are patient reviews of Clopixol Depot.
Reviews
Feedback about the experience of using the drug is quite common. The main positive characteristics of the drug are its effectiveness and prolonged action. Many patients note the convenience of rarely using Clopixol Depot. Reviews about the drug are not only positive.
Patients often note that when taking the drug, negative effects develop in the form of extrapyramidal disorders, apathy, and decreased libido.
It is important not to forget that the independent use of antipsychotics is unacceptable. The drug must be prescribed by a doctor.
special instructions
The drug should be taken with caution by patients with convulsive syndrome, chronic hepatitis, heart disease (including arrhythmias), as well as hypersensitivity to the components of the drug.
During long-term therapy, careful clinical monitoring of the patient's condition should be carried out periodically to decide whether to reduce the maintenance dose.
It must be borne in mind that when using Clopixol, in some cases, neuroleptic malignant syndrome (NMS) may occur with a fatal outcome. The main signs of NMS are: muscle rigidity, hyperthermia and impaired consciousness simultaneously with dysfunction of the autonomic nervous system (tachycardia, labile blood pressure, increased sweating). If these symptoms develop, Clopixol is immediately discontinued and symptomatic and supportive treatment is prescribed.
The drug may affect the ability to drive vehicles and other machinery. At the beginning of therapy, caution is recommended until the individual response to the drug used is determined.
