Deprim contraindications. Deprim instructions for use, contraindications, side effects, reviews

This drug is a plant-based antidepressant. Thanks to the specific influence of Deprim, an increase in mental activity and physical endurance is observed.

It is recommended to take the drug if:

• Emotional and psycho-vegetative disorders (severe emotional exhaustion, development of chronic fatigue syndrome, feeling of depression, decreased intellectual performance, lethargy)
• Signs of menopausal syndrome (frequent mood swings, depression)
• Meteosensitivity, with decreasing daylight hours.

The use of the drug Deprim is indicated to increase the overall tone of the body.

Release form

The drug is available in tablets with a dosage of 60 mg each. One package contains from 3 to 6 blisters of 10 tablets each.

The product is available in the form of tablets and capsules.

The tablets are film-coated and have a round, biconvex shape and green color. There are 10 pieces in one blister pack, three packs in a cardboard box.

The active substance of Deprim is a dry standardized extract of St. John's wort (60 mg in 1 tablet, including 300 μg of hypericin).

Auxiliary components of the drug are lactose, magnesium stearate, microcrystalline cellulose, talc and colloidal silicon dioxide.

The tablet shell contains polyethylene glycol, carnaubic wax, blue glaze, green glaze, talc, titanium dioxide and hydroxypropyl methylcellulose.

Deprim Forte capsules are a hard gelatinous substance of opaque green color. Their contents are compact granules of grayish-brown or greenish-brown color, size 0, with a characteristic odor.

One capsule of the drug contains 425 mg of dry standardized extract of St. John's wort (including 1 mg of hypericin) and auxiliary components: cellulose, colloidal silicon dioxide, gelatin, talc, lactose monohydrate, magnesium stearate, calcium hydrogen phosphate dihydrate, sodium lauryl sulfate, dyes and purified water.

Deprim Forte capsules are packaged in blisters of 10 pieces, 2 blisters in a cardboard pack.

The life of a modern person is filled with stress factors. In critical situations, the doctor prescribes antidepressants. Fast and safe action is provided by natural preparations based on herbal ingredients. Such a medicine is Deprim. The instructions for the herbal medicine will help you understand the peculiarities of its use and avoid possible negative consequences.

This drug based on St. John's wort extract is classified as a sedative and antidepressant medication. It is prescribed to children, adults, and elderly people.

The drug helps to find calm, balance, a person becomes more confident, active, and positive.

To understand the effect of a herbal medicine, it is important to study the composition of the product, indications for use, side effects and interactions with other drugs.

The main component of the drug, St. John's wort, contains hypericin, hyperforin, pseudohypericin and flavonoids, which improve the functioning of the central and autonomic nervous system.

The substance blocks the reuptake of norepinephrine, serotonin and dopamine.

This contributes to the manifestation of the antidepressant effect of the drug, which allows it to be used to treat apathy, appetite disorders, and sleep.

Within six hours after taking the first dose of the drug, 60% of pseudohypericin and 80% of hypericin are absorbed in the intestines.

As a result of research, it has been established that hypericin accumulates only in brain tissue.

The substance reaches its maximum concentration in the blood serum in 4-6 hours, the half-life is 24.8-26.5 hours. Hypericin is excreted primarily by the kidneys.

Medicinal properties

The active component of the drug is a substance of plant origin, namely St. John's wort extract. This phytocomponent includes hypericin, hyperforin, and pseudohypericin, which help normalize the functioning of the central nervous system and the autonomic system. The medicinal effect of the drug is due to the specific properties of the plant extract.

The medicine is used to treat apathetic conditions, eliminate ailments, increase general tone, normalize appetite and treat sleep disorders.

The drug has a positive effect on intellectual abilities and physical activity.

Interaction with other drugs

The drug Deprim is available in the dosage form of enteric-coated tablets for oral administration. They are round in shape and white in color. The tablets are packaged in blister packs of 10 pieces. A cardboard box contains 3, 4, 5 or 6 blisters of tablets, as well as instructions for use.

When using a medication with drugs from other pharmacological groups, the therapeutic effects may change:

• MAO inhibitors (monoamine oxidase) increase the risk of seizures and hypertensive crisis.
• A decrease in the intensity of drug metabolism in the liver, which is due to the fact that the active ingredient of Deprim tablets inhibits microsomal enzymes.
• Interaction with drugs of other pharmacological groups is possible within 2 weeks after stopping their use, which is associated with the cumulation (accumulation) of active substances in tissues.

Pharmacological groups

We invite you to familiarize yourself with Aevit soft capsules No. 50: instructions for use

Mechanism of action of Deprim

During the use of medication, in a small number of cases, negative reactions from various systems may develop:

• Digestive system – nausea, which may be accompanied by periodic vomiting, bowel dysfunction in the form of constipation.
• Central nervous system – feeling of fatigue, anxiety.
• Allergic reactions - skin rash, itching, Quincke's edema, urticaria.
• Skin – photodermatitis, accompanied by the development of inflammation when exposed to the ultraviolet spectrum of sunlight.

The following side effects may occur while using Deprim:

• From the gastrointestinal tract: vomiting and nausea, constipation;
• From the central nervous system: anxiety and feeling of fatigue;
• Allergic reactions: itching and hyperemia of the skin;
• Dermatological reactions: in patients with increased sensitivity to UV radiation, sunlight during treatment with the drug may cause burns (so-called photosensitivity).

Included in the group of herbal antidepressants and anxiolytics. Deprim affects the ANS and CNS, improves mood. Its sedative properties improve the quality of sleep, increase performance and physical endurance, and appetite.

Deprim is also characterized by a general tonic effect, improves gastrointestinal motility and blood circulation.

The drug Deprim is unique due to the auxiliary properties of St. John's wort, which promotes the regeneration of blood vessels and nerves; has antiseptic and anti-inflammatory effects. St. John's wort can have a beneficial effect in terms of psychosomatics for peptic ulcers, gallbladder diseases, hepatitis, cholecystitis.

There is evidence of the antibacterial effect of Deprim. It slows down and blocks the growth and reproduction of Streptococcus Pyogenes, reduces the resistance to penicillin of some resistant strains of microorganisms.

Deprim is a drug that acts slowly and smoothly, without causing drowsiness during the day, addiction or rebound syndrome, however, the course of treatment should be strictly limited.

Usually Deprim is very well tolerated; among the most common side effects, non-serious reactions are most often identified:

1. Dermatological symptoms, such as itching and redness of the skin, photosensitivity may increase, especially in patients with HIV; with prolonged exposure to the sun, a skin reaction in the form of erythema, a rash similar to sunburn may occur, you need to know this when taking Deprim.
2. Dyspeptic disorders such as constipation or diarrhea, epigastric pain, heartburn, bloating and flatulence.
3. From the side of the central nervous system - cephalea, irritability, fatigue.
4. Iron deficiency anemia may develop.

Often, the side effects caused by Deprim can be stopped at home; most of them begin in the first days of taking Deprim and quickly end so that they do not require treatment. If any symptoms cause discomfort, you should consult a doctor for advice and, possibly, to discontinue or replace Deprim.

Description and composition

The main active component of the drug is dry extract of St. John's wort. Its content in 1 tablet is 60 mg, which corresponds to 0.3 mg of hypericin. It also includes auxiliary components, which include:

• Talc.
• Colloidal silicon dioxide.
• Microcrystalline cellulose.
• Lactose.
• Magnesium stearate.
• Hydroxypropyl methylcellulose.
• Carnauba wax.
• Titanium dioxide.
• Purified water.

Dosage regimen

Regardless of the severity of the pathology, the minimum therapeutic dosage for adults is 180 mg of the active substance, which is divided evenly into three doses. If such therapy is ineffective, the dose can be increased gradually by 60 mg until a sedative effect is achieved.

The maximum permissible dosage is 360 mg of active substance per day. This corresponds to 6 Deprim tablets. For children, the minimum dose is 60 mg, the maximum is 120 mg. In the second case, it is divided into two doses. The drug is not prescribed to children under 6 years of age.

Deprim - description of the drug and release form, how to take and dosage, contraindications and reviews

The drug Deprim is prescribed to people with anxiety conditions, namely:

• during mild, short-term depression without suicidal thoughts, with anxiety;
• during menopause, especially with disorders of the autonomic nervous system;
• people with increased sensitivity to sudden weather changes.

When taking Deprim, a number of conditions can either cause an increase in side effects or change the activity of the therapeutic effect of the drug.

Among the relative contraindications of Deprim are:

• patient hypersensitivity to any of the substances contained in the drug;
• age up to 12 years, in some sources – up to 6 years;
• pregnancy;
• severe and prolonged forms of depression;
• lactase deficiency and other pathological conditions accompanied by lactose intolerance, as well as sucrose;
• increased sensitivity of the patient's skin to direct sunlight;
• with caution for people with insulin resistance and diabetes;
• chronic alcoholism;
• combination with antidepressants from the group of MAO inhibitors, indinavir, indirect anticoagulants (warfarin), cytostatics (azathioprim, methotrexate, cyclophosphamide, etc.).

According to the instructions, Deprim is prescribed for the following psychovegetative and emotional disorders:

• Irritability, fatigue, insomnia;
• Decreased mood;
• Mild to moderate depression accompanied by anxiety (including emotional disorders during menopause);
• Decreased ability to work, depression, general weakness, emotional exhaustion and chronic fatigue syndrome;
• Disorders associated with changing weather and decreasing daylight hours.

The use of Deprim is contraindicated in case of hypersensitivity to the components of the drug, in children under 6 years of age (for tablets) and under 12 years of age (for capsules), as well as in patients with severe depressive disorders.

The main medical indication for taking Deprim tablets is a decrease in mood of various origins, as well as changes in the functional state of the central nervous system.

There are several pathological or physiological conditions of the human body in which taking the drug is contraindicated, these include:

• Individual intolerance to any of the components of the drug.
• Severe depression, characterized by a prolonged and pronounced decrease in mood.
• Simultaneous use of drugs from other pharmacological groups, which include MAO inhibitors (monoamine oxidase), cyclosporine, antiretroviral drugs.
• The child's age is up to 6 years.

Analogs

If necessary, it is possible to replace the drugs Deprim and Deprim Forte with analogues; the drugs should be selected taking into account the nature of the pathology and the general condition of the patient.

Negrustin

Hexal, Germany

Price from 175 to 202 rubles.

It is an antidepressant drug based on phytocomponents. The sedative effect is ensured by the content of St. John's wort extract in the product. Shows a specific effect directly on the central nervous system. The drug should be used for excessive anxiety, depressive mood, and signs of asthenia. The release form of Negrustin is capsules.

Pros:

• Exclusively herbal composition
• Low price
• Effectively treats depressive conditions.

Minuses:

• Skin rashes may occur during treatment
• Not prescribed with cyclosporine
• Contraindicated in case of endogenous depression.

Doppelhertz Nervotonic

Queisser Pharma, Germany

Price from 332 to 431 rub.

The drug contains liquid extract of St. John's wort in combination with cherry liqueur. Used as an antidepressant and sedative. It has a positive effect on the activity of the central nervous system, helps normalize sleep, and reduce emotional stress. Available in the form of a liquid solution for oral administration.

Pros:

• Pleasant taste
• Does not cause drowsiness
• Available without a prescription.

Minuses:

• May cause dyspepsia
• Not compatible with MAO inhibitors
• Contraindicated in children under 12 years of age.

Neuroplant

Dr. Wilmar Schwabe, Germany

Price from 348 to 411 rubles.

The drug is an antidepressant; it helps normalize the psycho-emotional state. The medicine contains a phytocomponent - St. John's wort extract. Neuroplant is effective for psychovegetative disorders, constant feelings of anxiety, and frequent mood swings. Available in tablet form.

Pros:

• Convenient application scheme
• Quickly relieves nervous tension
• Rarely provokes adverse reactions.

Minuses:

• Not used when taking HIV protease inhibitors
• May provoke allergic reactions
• Not recommended for use on small children.

Overdose

If the recommended therapeutic dosage is significantly exceeded, weakness, drowsiness, lethargy develops, nausea appears, accompanied by periodic vomiting, and signs of negative reactions intensify. Treatment is symptomatic; there is no specific antidote for the drug. Severe acute poisoning with preparations of the medicinal plant St. John's wort has not been recorded.

The drug is taken orally with water.

Adults and adolescents over 12 years of age are prescribed one tablet 3 times a day. In children 6-12 years old, the dose of Deprim, according to the instructions, is 1-2 tablets (morning and/or afternoon) strictly under the supervision of a doctor.

Capsules of the drug are taken in the morning, preferably at the same time. The dosage is one capsule per day, but if the effectiveness is insufficient, it can be increased to two capsules (1 piece in the morning and in the evening).

The therapeutic effect appears 10-14 days after starting to use Deprim. If the patient’s condition does not improve within 1-1.5 months after the start of therapy, the drug should be stopped and consult a specialist.

If you miss another tablet or capsule of Deprim, you must take the drug as quickly as possible. If it is near the time of your next dose, you should not take an additional tablet or capsule to make up for the missed dose. Simultaneous use of two doses of the drug is prohibited.

Deprim is taken orally, per os (orally), washed down with plenty of water.

After consulting a doctor, 3 tablets per day are prescribed, regardless of meals; there should be about 8 hours between Deprim doses.

Reviews about Deprim

Due to the fact that the products contain the same active ingredient, reviews of Deprim Forte and Deprim are the same.

Reviews from doctors are mixed. Many of the future patients self-medicated while taking Deprim. Then the disease worsened and more serious medications had to be prescribed. Experts believe that St. John's wort extract can be effective for minor, mild degrees of depression and apathy, and mood swings.

You can find a lot of positive reviews on the forums. The medicine is taken during seasonal mood swings, after the loss of loved ones, during difficult periods in life. The drug helps with systematic, long-term use.

Adverse reactions occur rarely. Some people prefer to take the tablets before bed, rather than in the morning or afternoon, as indicated in the instructions.

The price of Deprim Forte is approximately 200 rubles for 20 pieces.

You can buy Deprim tablets for 156 rubles (30 tablets).

special instructions

During the period of use of Deprim, you should refrain from drinking alcoholic beverages and avoid exposure to the sun and artificial UV irradiation (for example, in a solarium).

Before you start using the drug, you should consider several special instructions, which include:

• Possible manifestations of the therapeutic effect should be monitored 4-6 weeks after starting the drug.
• It is not recommended to stay under the sun while using the drug.
• It is important to refrain from drinking alcohol while taking Deprim tablets.
• When used simultaneously with other drugs after their withdrawal, the risk of side effects increases.

During the course of treatment with Deprim, you should avoid sunbathing, solariums, and protect your skin from ultraviolet radiation with special creams and clothing.

Patients who regularly take drugs from other groups should consult a specialist about the possibility of using Deprim with them.

Women who were taking oral contraceptives before prescribing Derpim should consider a different type of contraception during the course of treatment.

Some doctors prescribe Deprim to children aged 6-12 years, 1 tablet per day to treat insomnia, nightmares, and hyperactivity. There is no clinically proven effect or harmlessness of this therapy.

There is no data from clinical trials on the effect of Deprim on the ability to engage in intellectual activities or those requiring increased attention.

Terms and conditions of storage

There are no specific instructions for storage, temperature up to 25°C, out of reach of children, do not take after the expiration date indicated on the package. Many pharmaceutical companies produce Deprim. Instructions for use usually describe the nuances of storage.

Deprim should be stored in a dark place, out of reach of children and pets. The temperature in the room where the drug is stored should not exceed 25°C. The shelf life of tablets and capsules is 3 years.

Storage in a dark, dry place, out of reach of children, at an air temperature not exceeding 25º C. Shelf life – 2 years.