Pharmacological action of Trittico
Trittico is a drug from the group of antidepressants. Trazodone is a triazolopyridine derivative that has an antidepressant effect. Has slight anxiolytic and sedative effects.
Trittico's mechanism of action is based on the drug's high affinity for individual subtypes of serotonin receptors, as well as its ability to inhibit serotonin reuptake.
The drug effectively affects somatic (headache, palpitations, frequent urination, muscle pain, hyperventilation, sweating) and mental (irritability, affective tension, insomnia, fear) symptoms of anxiety.
The drug helps improve mood, stabilize the emotional state, and reduce the pathological craving for alcohol in patients suffering from chronic alcoholism during withdrawal syndrome and during remission.
Trazodone is also effective in the treatment of sleep disorders and anxiety-depressive conditions during withdrawal syndrome in patients dependent on benzodiazepine derivatives. During remission, trazodone can completely replace benzodiazepines.
Trittico helps restore potency and libido in the presence of depression and in its absence.
In patients with depression, trazodone increases the duration and depth of sleep, restores its quality and physiological structure.
The drug does not affect the neutral uptake of dopamine and norepinephrine, body weight, and does not lead to addiction.
special instructions
During periods of depression, the risk of suicidal thoughts or behavior increases, including while taking antidepressants, especially before the age of 24 years. Therefore, before the onset of pronounced remission, patients need careful monitoring. If unusual changes in behavior occur, you should immediately seek advice from your doctor.
When prescribing Trittico to patients with cardiac conduction disorders, AV block, or after a recent myocardial infarction, the adrenolytic activity of trazodone and the risk of developing bradycardia and lowering blood pressure should be taken into account.
During the treatment period, it is recommended to periodically perform a peripheral blood test, including if a sore throat occurs when swallowing or fever. This will allow timely diagnosis of agranulocytosis and identification of cases of severe leukopenia.
Trittico's lack of anticholinergic action allows it to be prescribed for prostatic hypertrophy, angle-closure glaucoma, impaired cognitive function, and elderly patients.
If, while taking the pills, the patient experiences a prolonged and inadequate erection, it is necessary to consult a doctor.
Drinking alcohol is contraindicated while taking Trittico.
Trittico has a weak sedative effect, which can negatively affect the patient’s ability to concentrate and reduce the speed of his psychomotor reactions. In this regard, during the treatment period it is necessary to refrain from performing potentially hazardous activities, including driving vehicles and complex mechanisms.
Since the drug has adrenolytic activity, bradycardia and a decrease in blood pressure may occur when taken, so patients with conduction disorders, AV block, or myocardial infarction must be careful.
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The drug has sedative activity, so reaction speed and attention may be reduced. During the treatment period, you should refrain from activities that require increased attention and speed of psychomotor reactions.
Before you start taking the pills, you should pay attention to a few special instructions:
- The drug has adrenolytic activity, so its use may result in a decrease in blood pressure and the development of bradycardia.
- With long-term use of the drug, periodic laboratory monitoring of the condition of peripheral blood is required.
- Since the drug does not have a cholinergic effect, it can be used in older people, men with prostate adenoma, and people with angle-closure glaucoma.
- During drug therapy, the patient should not drink alcohol.
- An erection in men that is not associated with sexual arousal is a reason to consult a doctor.
- During drug therapy, potentially dangerous work is excluded.
Indications for use Trittico
According to the instructions, Trittico is used for:
- psychogenic depression (including neurotic and reactive);
- anxiety and depression caused by endogenous causes (including involutional depression);
- depressive states that occur in the presence of prolonged pain syndrome;
- anxiety-depressive states arising against the background of cerebral atherosclerosis, Alzheimer's disease, dementia;
- alcoholic depression;
- disorders of potency and libido;
- benzodiazepine addictions.
Patient opinions
Reviews from men about Trittiko are different. Some are completely satisfied with the effect of this drug. They say that after taking it, libido increased and the quality of sex improved. These people note that the drug improves mood, improves sleep, calms, and relieves hangover. The drug "Trittiko" has proven itself well for impotence. Reviews note that the result is visible after a few days of taking the tablets.
In addition to the effectiveness of the drug, side effects were constantly felt. Patients were concerned about nausea, vomiting, and drowsiness. Many people felt tremors in their limbs, confusion of thoughts, headaches, and stiffness of movement. There are people for whom this drug not only did not help, but also caused serious health problems. They do not recommend its use in the treatment of depression and believe that there are safer remedies.
Contraindications
According to Trittiko's instructions, the following cannot be used:
- in the presence of high sensitivity to the components included in the drug;
- during lactation;
- under the age of 6 years.
The drug is prescribed with caution:
- with AV block;
- with arterial hypertension;
- in the early recovery period after myocardial infarction;
- with ventricular arrhythmia;
- if there is a history of priapism;
- with renal or liver failure;
- under the age of 18.
Directions for use and dosage Trittico
Trittico is intended for oral administration.
Tablets should be taken half an hour before a meal or 2 hours after it.
The tablet should be swallowed without chewing and washed down with water.
Daily dose of Trittico:
- adults - 100 mg at bedtime (during the first three days of use). On the fourth day - 150 mg. Further, to achieve the best therapeutic effect, you can increase the dose every 3-4 days by 50 mg. If the daily dose is more than 150 mg, then it is divided into 2 doses (the main one is taken at night, the smaller one is taken in the afternoon);
- for libido disorders - 50 mg;
- for impotence - more than 200 mg (monotherapy), 50 mg (complex therapy).
- in case of benzodiazepine dependence, a gradual reduction of benzodiazepine doses occurs over several months. When the dose of benzodiazepine is reduced by ½-¼ tablet, the dose of trazodone is increased by 50 mg. This ratio is maintained for 3 weeks, then the dose of benzodiazepines is gradually reduced until they are completely discontinued. Then the daily dose of Trittico is reduced every 3 weeks by 50 mg.
- elderly and weakened patients - up to 100 mg (can be divided into several doses). The dose can be increased only under the strict supervision of a physician. Typically, doses higher than 300 mg are not required.
- children 6-18 years old - 1.5-2 mg per kg of weight (several doses). If necessary, the dose is increased to 6 mg per kg of weight in several doses with an interval of 3-4 days.
The daily dose for patients undergoing outpatient treatment should not exceed 450 mg, for inpatients - 600 mg.
Reviews from doctors
Only after consultation with a specialist is it recommended to use the drug "Trittiko" instructions for use. Reviews from doctors about this drug are good. They believe that the initial stage of anxiety-depressive syndrome can be easily cured. According to experts, the tablets are a good treatment for insomnia and help with impotence. You need to start with 50 mg at night.
Doctors note that when treating with this drug, you should not sharply increase the dosage. To avoid side effects, tablets should be combined with medications to improve blood circulation and with medications that improve metabolic processes, as well as sedatives.
Side effects of Trittico
According to reviews, Trittico may cause adverse reactions.
Cardiovascular system: orthostatic hypotension, decreased blood pressure, arrhythmia, bradycardia, conduction disturbances, neutropenia, leukopenia.
Central and peripheral nervous systems: drowsiness, fatigue, headache, agitation, weakness, dizziness, myalgia, paresthesia, incoordination, tremor, disorientation.
Digestive system: bitterness and dry mouth, diarrhea, nausea, vomiting, decreased appetite.
Other: eye irritation, allergic reactions, priapism.
Overdose
During research to study the effects of the active substance on the human body, it was revealed that the chemical compound can provoke side effects.
More often, the risk of their development is associated with the patient’s individual health characteristics, incorrect dosage calculations, and neglect of the doctor’s recommendations regarding the medication regimen.
When using an antidepressant in therapy, the following negative manifestations are possible:
- insomnia;
- physical weakness due to low blood pressure;
- fast fatiguability;
- impaired coordination of movements;
- stomach and intestinal disorders;
- myalgia;
- semi-fainting, fainting states;
- decrease in white blood cell units in the blood;
- disturbance of sinus heart rhythm;
- decrease in the number of neutrophils in the blood;
- sinusitis;
- arrhythmia.
Before using the medicine, you should study the instructions to exclude side effects of an allergic nature. If you are allergic to one or more components, you should stop taking the tablets.
Exceeding the daily norm or duration of therapy creates a danger to the body.
This can be felt by the following alarming signs:
- worsening side effects;
- drowsiness;
- decreased blood pressure;
- problems with the respiratory system or respiratory arrest;
- priapism;
- nausea;
- epileptiform seizures.
To eliminate symptoms, it is recommended to rinse the stomach, perform forced diuresis, and take a sorbent.
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Sometimes you have to resort to drastic measures. For example, irrigation of the cavernous bodies using epinephrine, removal of stagnant blood, shunting.
The drug "Trittico" (reviews from doctors and patients note that the drug has a strong hypnotic effect) requires strict adherence to the dosage, otherwise an overdose may occur. As a rule, this is a gag reflex, drowsiness, nausea, dizziness. In especially severe cases, tachycardia, cramps in the limbs, hypotension, disruption of the respiratory and cardiac apparatus, and hyponatremia may appear. All of the above symptoms appear in a person within 24 hours.
The drug "Trittiko" can also cause negative effects, such as agranulocytosis, leukopenia, anemia, eosinophilia and thrombocytopenia. Patients complained of allergic reactions. Some experienced mental disorders, which manifested themselves in the form of phobias, confusion, fear, suicidal behavior, and hallucinations.
When treated with this medication, especially at high dosages, epileptic seizures, headaches and dizziness occurred. Drowsiness occurred. There was tremor, amnesia, and taste preferences often changed. During therapy, people were worried about tachycardia, increased heart rate, bradycardia, decreased and increased blood pressure. Ventricular extrasystoles occurred. QT interval prolongation has been observed. In some cases, patients lost consciousness.
Other side effects included nausea, abdominal pain, vomiting, diarrhea, dry mouth, and excessive salivation. A rash appeared on the skin, itching, and sweating.
Interaction with other drugs
When using Trittico simultaneously with:
- antihypertensive drugs - a reduction in the dosage of the latter is required;
- CNS depressants (methyldopa, clonidine) - the effect of the latter is enhanced;
- antihistamines and drugs with anticholinergic activity - the anticholinergic effect of trazodone is enhanced;
- tricyclic antidepressants, loxapine, haloperidol, maprotiline, pimozide, phenothiazine, thioxanthene - anticholinergic and sedative effects are enhanced and prolonged;
- MAO inhibitors - the risk of adverse reactions of trazodone increases;
- digoxin and phenytoin - their concentration in plasma increases.
During pregnancy
According to the instructions, the use of Trittico is contraindicated during pregnancy and breastfeeding. There is no data on the ability of trazodone hydrochloride to penetrate the placental barrier; therefore, an objective assessment of the effect of taking the drug on fetal development and the general course of pregnancy is impossible. The substance passes into breast milk, therefore, if there is an urgent need to treat the mother with the use of this antidepressant, the process of feeding the baby should be suspended.
