The drug Akineton: instructions for use and reviews

Composition and release form

You can buy this medicine in the form of tablets or injection solution.

The tablets are white in color and have a flat-cylindrical shape. Each of them contains 2 mg of biperiden hydrochloride, which is the main active substance. Also, the drug "Akineton", the instructions for use of which are described in this article, contains potato and corn starch, lactose monohydrate, magnesium stearate, calcium hydrogen phosphate, talc and water. The tablets are packaged in blisters of ten or twenty pieces. Sold in cardboard packs of two, five or ten blisters.

Akineton injections (instructions for use are given in this article) are available in ampoules of one milliliter. Each ampoule contains 5 mg of biperiden lactate, as well as excipients such as sodium lactate and purified water for injection. At the pharmacy you can buy this drug in a package containing five ampoules.

Pharmacodynamics and pharmacokinetics

The active substance is biperiden. The main substance is a centrally acting anticholinergic blocker.

The mechanism of action is aimed at inhibiting the activity of cholinergic neurons in the structural component of the extrapyramidal system - in the striatum.

The drug has a ganglion-blocking effect, antispasmodic and moderate peripheral m-anticholinergic effects.

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The medication is able to eliminate catalepsy, muscle rigidity caused by taking antipsychotics, as well as tremors of the limbs while taking cholinergic medications, for example, pilocarpine.

The drug can cause psychomotor agitation.

Who should use it?

The drug "Akineton" is very often prescribed in the following cases:

• poisoning with phosphorus-containing or nicotine substances;
• in the presence of parkinsonism syndrome in adults;

• for extrapyramidal syndromes caused by antipsychotics or other similar drugs. In this case, the medication is prescribed to both children and adults.

Are there any contraindications?

Be sure to consult your doctor before using this drug. You should not self-medicate. "Akineton", reviews of which are positive, should under no circumstances be taken if you have an individual intolerance to any component included in the medicine.

Doctors prohibit taking the drug if you have the following diseases:

• angle-closure glaucoma;
• significant change in prostate size;
• intestinal obstruction;
• pyloric stenosis.

With extreme caution and under the strict supervision of a doctor, the drug can be prescribed to people suffering from epilepsy, arrhythmia, as well as pregnant and lactating women.

exHANTER 26 Feb 2020

No, I don’t think anything good will come from this. I remember a case when cyclomed was dripped into one of the nostrils, one marginal man gave a sharp pressure to one nostril, well, what can I say, it didn’t hit him any harder. In general, Akinetone is specific to Cyclodol. from which, at certain dosages, you can catch delirium with galinas, with Akineton this will ride on the verge of a foul for the whole organism, and even then it is in doubt. Why? This is stated in the instructions at the very beginning).

A young psychiatrist I know, with whom we were not averse to trying Mitrofan and various acids, used to say that there is no point in eating Akineton to “increase your mood” with more than 2 tablets of 2 mg each. The same goes for catching glitches from it. Please listen. to this, lovers of choline torch)

"Akineton": side effects

Despite such effective properties, this drug still has many disadvantages, which are manifested by various side effects.

From the central nervous system, patients may experience increased fatigue, drowsiness, dizziness, a constant feeling of anxiety, impaired memory and thought processes, as well as confusion and addiction to this medicine.

The drug "Akineton" also has side effects on the visual system. In some patients, accommodation was impaired, as well as mydriasis.

The drug can also have a negative effect on the cardiovascular system. When using tablets, some patients developed tachycardia and bradycardia. During the injection method of treatment, blood pressure may increase.

In some patients, metabolism is disrupted, sweating decreases, constipation appears, or, conversely, diarrhea.

It is possible that allergic reactions may occur, manifested by a skin rash or itching.

pharmachologic effect

Pharmacodynamics

Akineton is a centrally acting anticholinergic drug that reduces the activity of cholinergic neurons of the striatum (belong to the structural components of the extrapyramidal system). The peripheral anticholinergic effect of biperiden is less pronounced.

Biperiden reduces rigidity and tremor. Leads to psychomotor agitation and autonomic disorders.

Pharmacokinetics

After taking biperiden orally, Cmax (maximum concentration of the substance) is 1.01–6.53 ng/ml, the time to reach it is from 30 to 120 minutes. Css (equilibrium concentration) after oral administration of 2 mg of the drug 2 times a day is achieved in 15.7–40.7 hours. Bioavailability after a single dose is approximately 33 ± 5%.

The binding of biperiden to plasma proteins after oral and parenteral administration ranges from 91 to 94%. Plasma clearance – 11.6 ± 0.8 ml/min/kg.

Biperiden is excreted in breast milk.

The substance is completely metabolized. Its main metabolites are piperidine and bicycloheptane.

Excretion is carried out in feces and urine in the form of metabolites and occurs in two phases. T1/2 (half-life) of the first phase is 1.5 hours, the second is 24 hours.

In elderly patients, the T1/2 value may increase to 38 hours.

The use of Akineton in some cases can cause:

• Drowsiness;
• Dizziness;
• Ataxia;
• Weakness;
• Anxiety;
• Increased fatigue;
• Dyskinesia;
• Confusion;
• Nervousness;
• Euphoria
• Memory impairment;
• Delirious disorders;
• Insomnia;
• Muscle cramps;
• Speech impairment.

In some cases, hallucinations may occur. If there is increased stimulation of the nervous system, the dose of the drug should be reduced.

Also, the use of Akineton can provoke:

• Digestive system disorders - constipation, enlarged salivary glands, dry mouth, nausea, epigastric discomfort. To reduce the development of such undesirable effects, it is recommended to take the drug after meals;
• Tachycardia, bradycardia and decreased blood pressure;
• Visual impairment – ​​angle-closure glaucoma, accommodation paresis, mydriasis;
• Allergic reactions, decreased sweating, difficulty urinating;
• Drug addiction.

Side effects are most often observed in the early stages of treatment, as well as when the dose is increased too quickly.

In case of an overdose of Akineton, the following symptoms may be observed:

• Redness of the skin;
• Hyperthermia;
• Atony of the bladder and intestines;
• Delirium;
• Dilated pupils that react slowly to light – mydriasis;
• Confusion;
• Collapse;
• Dry mucous membranes;
• Cardiopalmus.

The simultaneous use of Akineton with other anticholinergic psychotropic drugs, as well as with antiparkinsonian, antihistamine and antiepileptic drugs may increase peripheral and central side effects.

You must also be careful when combining the drug with Levodopa, Pethidine, Quinidine and some other drugs.

The main substance biperiden is a centrally acting anticholinergic blocker.

The effect suggests a suppressive ability on the activity of cholinergic neurons in the striatum, which is a structural unit of the extrapyramidal system.

The drug causes a ganglion-blocking effect, antispasmodic and a moderate m-anticholinergic effect on the periphery (spasmolytic).

The use of the drug helps eliminate limb tremor, which occurs when using cholinergic drugs (for example, pilocarpine), as well as catalepsy and muscle rigidity while taking antipsychotics. Has the ability to provoke psychomotor agitation.

On the part of the central nervous system, they are manifested by asthenia, increased fatigue, drowsiness, weakness, stupor, dizziness, feelings of concern, anxiety, memory impairment, confusion, hallucinations, catalepsy, drug dependence on the drug "Akineton".

The instructions for use talk about side effects on the organ of vision - mydriasis, disturbance of accommodation.

On the part of the cardiovascular system, it is characterized by an increase in heart rate (tachycardia); sometimes - slowdown (bradycardia); when using the injection form of the drug - a decrease in blood pressure (hypotension).

From the digestive system - dry mouth, dyspeptic symptoms, constipation.

From the side of metabolic processes - a decrease in sweating.

From the urinary system - in patients with enlargement (hypertrophy) of the prostate gland - possible difficulty urinating.

Allergic manifestations: rash on the skin, itching.

"Akineton" when used simultaneously with m-anticholinergics, drugs with antihistamine and antiepileptic effects increases the severity of the latter. However, simultaneous use with metoclopramide weakens its therapeutic effect.

The drug is strictly incompatible with ethanol. Prescribing quinidine significantly increases the risk of developing manifestations of dyskinesia. The M-cholinergic effect is enhanced by the use of levodopa.

Rules of application

The drug "Akineton", the price of which is indicated in this article, can be used orally, or through intramuscular and intravenous injections.

According to the instructions for use, as well as the advice of doctors, this drug should be taken gradually, starting with the smallest doses and gradually increasing them, depending on what effect the patient needs, as well as depending on the presence of side effects.

When using tablets for adults, you should start with a dosage of one milligram of the substance per day, which should be used in one or two doses. You can gradually increase the dosage to eight milligrams per day. But this needs to be done gradually. Do not exceed the daily dose under any circumstances, otherwise side effects may occur.

If your doctor has prescribed you an injection form of treatment, please note that you should not administer more than five milligrams of the drug at a time. The maximum daily dose is 20 mg, which must be divided into four injections.

However, please note that in each specific case the dosage is selected individually, and only your attending physician can do this.

In the case of extrapyramidal syndrome, Akineton tablets are usually prescribed in a dosage of 2 mg, which can be taken every half hour. However, there should be no more than four such receptions per day.

For Parkinson's disease, this medication should be taken orally two to four times a day. Typically, the initial daily dosage is 6-8 mg, but over time it can be increased to 16 mg. This should be done under the strict supervision of your doctor.

Children under one year of age are allowed to use the drug only in the form of injections, which should be administered very slowly. A single dose for children is 1 ml. For children under six years of age, a dosage of 2 ml is suitable. For children from six to ten years old, doctors recommend administering 3 ml. If there is an urgent need, then the injection procedure can be performed in half an hour. If side effects occur, treatment with this drug should be stopped immediately and replaced with another.

Sometimes doctors allow children to use medication in tablet form. In this case, the dosage should be 1-2 mg per day, which should be divided into several doses.

You should not take this medicine on an empty stomach. Take each tablet with a moderate amount of water. If after using the drug you begin to notice side effects from the digestive system, then try taking the tablet immediately after eating. Such a simple fraud can save you from discomfort in the digestive system.

"Akineton", reviews of which you can read in this article, are sometimes prescribed to patients poisoned by nicotine and other organic substances. In this case, this medicine is administered in a dosage of 5-10 mg. However, it is used only in emergency cases.

If the patient is poisoned with a phosphorus mixture, the drug is administered intravenously. In this case, the dosage is selected individually, and treatment lasts until the signs of poisoning completely disappear.

exHANTER 25 Feb 2020

You guys try it, drink it in the evening, when you’re feeling low on something, then you’ll see how it lifts your mood, well, for an hour or two, then I always wanted it to go away faster, and that’s with 1-2 tablets. I don’t know, maybe the withdrawal of baklosan is to blame. most likely, but after a weak BD it goes well, but this is drug addiction and not treatment, and the dose of BD should be minimal. I am writing my feelings based on recent experiences. The first pack was a year and a half ago, when I ate it with baclofen (in the morning), gabapentin in the late afternoon, and Akineton at 10-11, then yes there were cheerful sensations. I didn't take anything else. And this is not a dubious innovation, as they write in neighboring branches, time is running forward. Although it does not tax the heart and motor skills like cyclodol (which is disgusting to remember) Minus of Akineton, there is no muscle relaxation like cyclodol, and this is sometimes necessary, the degree of euphoria, if you can call it that, is lower, and it lasts a long time. There are also advantages, for me, there is no waste. However, that's all in the past

"Akineton": overdose

Take this medicine strictly as directed by your doctor. An overdose of biperiden can lead to negative consequences. At the same time, it is impossible to predict in advance which organ will be at risk.

Most often, patients experienced the following consequences of an overdose:

• the pupils reacted very slowly to light;
• mucous membranes became excessively dry;
• the skin became covered with red spots;

• increased heart rate;
• hyperemia;
• diseases of the central nervous system;
• disturbances of coordination, memory and thought processes.

What properties does Akineton have?

Akineton is an anticholinergic drug that has a central effect. When ingested, it reduces the activity of cholinergic neurons of the striatum, which is part of the structure of the extrapyramidal system. Akineton also exhibits anticholinergic peripheral effects, but to a less pronounced extent.

The drug can reduce the symptoms of tremor that are provoked by cholinergic drugs. Catalepsy and muscle rigidity that develop while taking antipsychotics are also eliminated. It should be taken into account that biperiden hydrochloride causes psychomotor agitation in patients.

After entering the body, the highest concentration in the blood is observed after 0.5-2 hours. The active substance binds to plasma proteins by 94%. Bioavailability is approximately 33% (after a single dose).

In the body, biperiden disintegrates completely. Metabolites are formed (bicycloheptane and piperidine), which are excreted in feces and urine. Elimination is carried out in two phases, the half-life for the first is 1.5 hours, for the second - 24 hours.

Interaction with other drugs

Please note that using this drug concomitantly with other anticholinergic, antiparkinsonian, and anticonvulsant medications will result in increased side effects.

The use of Quinidine during treatment may increase the negative effect on the cardiovascular system.

Do not forget that Akineton and alcohol are absolutely incompatible, since the drug significantly enhances the effect of alcohol on the central nervous system. Therefore, during the course of treatment, give up alcohol.

Storage rules

Please note that buying this drug is not so easy. Before going to the pharmacy, you definitely need to see a doctor and get a prescription from him.

The medication must be stored in the right conditions, otherwise it will lose its effectiveness and be hazardous to health.

Tablets and ampoules should be stored at a temperature not exceeding 25 degrees Celsius, away from sunlight and children.

If the correct storage conditions are observed, Akineton can be used for five years from the date of manufacture.

Akineton 23 Feb 2020

For me, Akineton significantly improves my mood. I take it without antipsychotics. Do you think it’s harmful in the amount of four tablets a day? Why does it make me feel good?
I also use it against depression when nothing helps, but the antidepressant effect is small, it rather, it is a stimulant against the side effects of all psychotropic substances, it also has a useful function, it removes nicotine and other poisons. I take antipsychotics and tranquilizers at night, because I have Akineton, a lifesaver, it’s hard in the morning without a corrector. Doctors have only given it a good rating compared to cyclodol.

Important instructions

The drug is not recommended for use by pregnant and lactating women. However, in case of serious need, a woman should stop breastfeeding, since the active components of the drug can pass into breast milk. Please note that when using this remedy during pregnancy, there is a risk of fetal loss.

With extreme caution, the medicine is prescribed to elderly people, as well as people suffering from epilepsy and arrhythmia.

You should not use the drug for too long, as there is a risk of developing drug dependence.

You should not drive vehicles during treatment, as the drug can reduce concentration and confuse consciousness.

Reviews

Reviews from doctors and patients about this product confirm its effectiveness. However, everything depends on the correct dosage. You should not immediately take large doses, it is better to increase them gradually. Doctors strongly recommend monitoring your general health during the course of treatment: regularly see a doctor and get tested. According to the collected reviews, the drug is tolerated quite well. Side effects are extremely rare. Most often in case of overdose.

This drug has shown to be highly effective in the treatment of Parkinson's syndrome. Tremor in the limbs disappears very soon after starting use. The disadvantages include the high cost of the drug "Akineton". The price for tablets is about 600 rubles. But for injections you will have to pay about 900 rubles.

Despite many shortcomings, this medication still copes well with its tasks. When used correctly, the risk of developing negative consequences is extremely low. Strictly follow your doctor's recommendations, take your medicine on time, and very quickly you will be able to notice the first positive results. And if the drug does not suit you, do not worry, there is always the opportunity to find a replacement.