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Cavinton is a drug that has a nootropic, antihypoxic, and vasodilator effect. It improves blood circulation in the brain, normalizes brain metabolism, increases the amount of glucose and oxygen consumed, and reduces the resistance of blood vessels in the head. The active ingredient is vinpocetine.

Indications for the use of the drug include ischemic stroke, consequences of hemorrhagic stroke, vascular dementia, cerebral atherosclerosis and other diseases associated with circulatory failure in the vessels of the head.

For ophthalmological diagnoses, Cavinton is prescribed for diseases of the choroid of the retina. For otorhinolaryngological problems, the drug is prescribed for Meniere's disease, idiopathic tinnitus, for the treatment of perceptual hearing impairment.

The medicine is manufactured in Hungary, as well as in Russia. The price for Cavinton varies from 240 to 700 rubles. Release form: tablets, injection solution. There are many cheap analogues of the drug and close substitutes made in Russia or imported.

Use of the drug

Any type of Cavinton contains the active ingredient vinpocetine. It immediately affects several key points in the functioning of brain cells:

• Reduces the activity of the inhibitory systems of the brain;
• Increases the absorption of oxygen and glucose by brain tissue;
• Increases the resistance of nerve cells to lack of oxygen;
• Increases the activity of the excitatory systems of the brain;
• Improves blood circulation through the cerebral arteries.

Due to all these mechanisms, metabolic processes in nerve cells are normalized and they work better. The positive effect will not always be noticeable immediately - sometimes it may take 1-2 weeks of taking the medicine to improve your well-being.

• Cavinton: Tablets 5 mg, 50 pcs. – 250 – 270 rub;
• Ampoules 10 mg 2 ml, 10 pcs. – 230 – 250 rub;
• Ampoules 25 mg 5 ml, 5 pcs. – 330 – 350 rub;
• Ampoules 50 mg 10 ml, 5 pcs. – 330 – 350 rub;

Ingredients: Vinpocetine

Pharmaceutical groups:

• Correctors for cerebrovascular accidents

According to the instructions included in the package, you should take the medicine after meals to reduce the likelihood of side effects. After achieving the desired effect, the doctor will reduce the dosage to a minimum to maintain the effect. The course of treatment lasts 2-3 months, but the patient’s condition improves mainly after 10-14 days.

The drug in the form of a solution is used to treat neurological pathologies and circulatory disorders. Before use, the medicine must be mixed with saline and then administered by drip. When the desired result is achieved, the patient is transferred to tablets.

Cavinton is also used to treat childhood pathologies, especially seizures after a head injury. In this case, an injection solution is used, and when visible results are achieved, the child is given the drug in tablet form to maintain the effect. The course of therapy is carried out under the supervision of a doctor; it is not recommended to use the medication on children under 18 years of age.

• Both medications improve cerebral blood flow.
• The main active component is vinpocetine, which has a complex of actions that can improve the functioning of the circulatory system. The component has a beneficial effect on metabolism and reduces blood clotting.
• Prescribed for the treatment of mental and neurological pathologies that arise due to deterioration of blood flow to the brain.
• Can be used to treat diseases of the eyes and hearing, which also appear as a result of circulatory problems.
• Can eliminate the consequences of a stroke and mechanical damage to the skull.
• The active substance helps restore strength after injuries.

Medicines are available in the form of flat tablets of white or almost white color (with a yellowish coating). The difference lies in the content of the active substance in the drug: in Cavinton it is 10 mg, in Vinpocetine it is 5 mg. There is another form of release: ampoules with colorless or slightly colored liquid for injection.

The drugs are taken orally after meals. The maximum daily dose of vinpocetine for a patient is 30 mg, the initial dose per day is 15 mg. Depending on the severity of the disease, the doctor may prescribe 5-10 mg 3 times a day. For injection, a single dose of the substance is 20 mg; treatment is usually prescribed in the acute stage of the disease.

The full therapeutic effect is achieved no less than 3 months after taking the medicine, the first positive changes occur approximately a week after the start of treatment.

According to tests, Cavinton has negative compatibility with the following substances:

• A-methyldopa. When they are combined, the hypotensive effect is enhanced;
• Heparin and amino acids. Using them in the same mixture for drip injection is strictly prohibited, since chemically they are not compatible.

• November 1, 2018
• Other drugs
• Gena Poddubny

Cavinton Comforte is described in the instructions for use as a product intended to improve blood circulation in the brain. This article will discuss who needs to take this drug, as well as existing contraindications, instructions for use and other features.

Cavinton and Cavinton Comforte are medications containing vinpocetine as an active ingredient. This component, acting on the tone of the walls of blood vessels, has a vasodilating effect, acting primarily selectively on ischemic areas of brain tissue.

Under the influence of vinpocetine, the rheological properties of blood and the deformability of red blood cells improve, which contributes to a better supply of oxygen to tissues fed by small capillaries. The tolerance of oxygen starvation by nerve cells under the influence of vinpocetine increases significantly.

Cavinton is a drug that has a nootropic, antihypoxic, and vasodilator effect. It improves blood circulation in the brain, normalizes brain metabolism, increases the amount of glucose and oxygen consumed, and reduces the resistance of blood vessels in the head. The active ingredient is vinpocetine.

Indications for the use of the drug include ischemic stroke, consequences of hemorrhagic stroke, vascular dementia, cerebral atherosclerosis and other diseases associated with circulatory failure in the vessels of the head.

For ophthalmological diagnoses, Cavinton is prescribed for diseases of the choroid of the retina. For otorhinolaryngological problems, the drug is prescribed for Meniere's disease, idiopathic tinnitus, for the treatment of perceptual hearing impairment.

The medicine is manufactured in Hungary, as well as in Russia. The price for Cavinton varies from 240 to 700 rubles. Release form: tablets, injection solution. There are many cheap analogues of the drug and close substitutes made in Russia or imported.

"Cavinton Comforte" is available in the form of a dosage form such as almost white or white dispersible tablets, biconvex round, engraved "N83" (in a cardboard pack there are two, six or nine blisters of fifteen tablets each).

One tablet contains: active ingredient – ​​10 mg of vinpocetine; excipients: mannitol, stearic acid, pregelatinized corn starch, crospovidone, sodium stearyl fumarate, butyl methacrylate copolymer, magnesium stearate, colloidal silicon dioxide, low-substituted hyprolose, aspartame, sodium lauryl sulfate, dimethicone, orange flavor.

pharmachologic effect

• The use of Cavinton and Cavinton forte helps to dilate cerebral vessels, activate blood flow, improve oxygen supply to the brain and utilize glucose.
• The active ingredient is vinpocetine. Cerebral vasodilation is associated with the relaxing effect of vinpocetine on smooth muscle. Activates the exchange of norepinephrine and serotonin in brain tissue, increases the plasticity of red blood cells and reduces blood viscosity.
• Able to cause a slight decrease in blood pressure immediately after administration.

Features of the drug

Both Comfort and Forte serve to dilate blood vessels located in the brain. The effect allows you to improve blood flow and the supply of oxygen with glucose. The result is achieved thanks to vinpocetine, which is able to relax the smooth muscle tissue of blood vessels. In addition to the main effect, the medicine stimulates the exchange of norepinephrine and serotonin in the brain, reduces blood viscosity and makes red blood cells more elastic.

Cavinton 5 mg is the regular version of the drug, there are usually 50 tablets in a package, and 5 mg means the amount of the main active ingredient. Prescribed for prophylactic purposes and for mild forms of the disease.

Forte is a more advanced form of the drug and contains 10 mg of vinpocetine. This type is created in the form of tablets of 30 and 90 pieces. For the drug Cavinton Forte, the prefix means modification. She talks about increasing the amount of the main component. However, it is impossible to say for sure that Forte is better than the regular version due to a more serious concentration of vinpocetine.

The Comfort version was created recently and its main difference from other versions is its ability to dissolve in saliva. This effect is useful for people with spasms that occur when swallowing. The drug contains 10 mg of vinpocetine and is produced in the form of tablets of 30 and 90 pieces. packaged. It is usually excreted, like other versions of the drug, through feces and urine. The half-life is 5 hours.

There is also a version of Cavinton in the form of an injection solution. This form is characterized by ampoules of 2.5 and 10 ml, in a package there are 5 and 10 pieces. 1 ml of this solution contains 5 mg of the main active ingredient, so you need to select the dose carefully and without the knowledge of the doctor, it is better not to take this drug at all.

Composition of the drug

The medicine is produced by a Hungarian pharmaceutical company in the form of round white tablets with the inscription CAVINTON. The healing substance is vinpocetine, which is a plant alkaloid.

Each tablet contains 5 mg of vinpocetine and additional inactive ingredients for preservation and shaping. A paper pack contains 20, 30 or 50 tablets in blister packs.

Cavinton tablets and ampoules: instructions for use, price in pharmacies, reviews from doctors and patients

Tatyana Ivanovna, 47 years old, neurologist, Lipetsk

Increasingly, patients over 40 years of age are being diagnosed with problems with the nervous system. This process is explained by the fact that, against the background of a sedentary and sedentary lifestyle, blood circulation in the tissues is disrupted. Insufficient oxygen reaches the brain, which leads to starvation and tissue atrophy. Therefore, Cavinton Forte is included in complex therapy. It is better because it contains 10 mg of active ingredient, which allows you to achieve a faster effect.

In severe cases, for example after an ischemic stroke, it is recommended to give injections. If it is necessary to carry out prophylaxis, then a smaller dosage is prescribed, which is contained in Cavinton.

Alexander Valerievich, 52 years old, therapist, Krasnodar

Varicose veins are considered one of the common problems in women. To improve blood flow from the lower extremities to the brain, Cavinton is recommended. It is not a key drug; it is used as an additional treatment with ointments and tablets.

Cavinton is contraindicated for children under 18 years of age, since the effect of the substances included in the medication on the children's body has not been fully studied. However, there are a number of exceptions in which the doctor may prescribe this drug in a strictly prescribed dosage and under the close supervision of adults.

Such exceptions include:

• postpartum trauma;
• hearing loss;
• encephalopathy.

The doctor prescribes the dosage of the drug at his own discretion. Under no circumstances should you make your own decision about treating children with this medicine without consulting a specialist.

As already mentioned, in all types of Cavinton the active ingredient is vinpocetine. The difference between the drugs is the release form and dosage. Regular Cavinton can be found both in the form of 5 mg tablets and in injectable form. Forte and Comfort are available only in tablet form, where each tablet contains 10 mg of active ingredient.

The main difference between Cavinton Comforte tablets and other Cavinton tablets is their dispersion. That is, they do not need to be chewed and swallowed - they dissolve themselves in the oral cavity and are quickly absorbed into the systemic bloodstream. This is much more convenient when using the medicine for a long course of treatment, since it does not require a constant search for water to wash down the tablet.

Cavinton Comforte tablets have clear advantages over Forte tablets. They are easier to use on a daily basis and the positive effect from them also comes faster. However, if we talk about a course of treatment of 2 - 3 months, then the speed of onset of the effect from taking one tablet does not make any sense - the only important thing here is that the drug itself is taken over a long course and it does not matter in what form.

If it doesn’t matter to you whether you need to take a pill or not, then it doesn’t matter what type of drug you take during a long course of treatment. Comfort is suitable for people who cannot always find a way to take a pill (drivers, dispatchers, etc.). Comforte is also good if you need to quickly relieve dizziness, noise in the head or ears that is not associated with increased blood pressure.

It is classified as a drug that corrects cerebral circulation.

Why is Cavinton forte prescribed?

• reduction in the severity of mental or neurological symptoms in cerebrovascular insufficiency (including recovery after ischemic strokes, ischemic attacks (transistor), in cerebral atherosclerosis and coronary heart disease);
• treatment of hypertensive/post-traumatic encephalopathy;
• chronic forms of vascular pathologies of the eyes;
• hearing loss, Meniere's disease (in otorhinolaryngology);
• other vascular pathologies (including varicose veins).

Cavinton Forte is prescribed for the treatment of varicose veins.

Medicinal properties

The mechanism of action of the drug depends on several points: improvement of cerebral blood flow by accelerating metabolic processes in the body, a positive effect on blood binding in terms of improving rheological qualities. The neuroprotective properties of the drug are manifested by blocking sodium and calcium channels.

After oral administration, metabolic processes in the brain are activated by increasing the uptake and consumption of glucose with oxygen. With regular use, the tolerance of hypoxia by the heart and brain also improves. The transport of glucose, which is the main source of energy for the brain, improves, and the active substance itself penetrates well through the blood-brain barrier, so metabolic processes shift towards a more acceptable type of aerobic exercise. The product also improves the exchange between the neurotransmitters serotonin and norepinephrine, due to which the antioxidant properties of the drug are manifested.

Thanks to the improvement of microcirculation in the brain, a persistent antiplatelet effect occurs, blood viscosity decreases, and the deformability of red blood cells increases. The product helps to better supply oxygen to cells due to the fact that the affinity for red blood cells is slightly reduced. The medication is also good because it increases blood flow in the brain without a pronounced effect on the blood vessels, it does not dilate them and does not have a hypotensive effect (the effect on the results of measuring blood pressure after administration is negligible). After oral administration, it is rapidly absorbed, mainly in the upper intestines.

If we take preclinical studies, the amount of radioactively labeled substance is determined in the blood in the highest concentration within 2-4 hours after oral administration. Approximately 65% ​​bound to blood proteins. The distribution of the substance throughout the body is linear. The substance is excreted in the urine through normal glomerular filtration in the kidneys.

Difference between Cavinton and Cavinton Comfort

These tablets are well tolerated, unlike Cavinton. According to statistics, a regular drug is more likely to cause side effects than one labeled “comfort”. This analogue is also dispersed.

Reviews from doctors

Aliya Gerasimova (therapist), 40 years old, Voronezh

The drug is recommended for use for pathologies of blood circulation/metabolism in the brain. As part of complex therapy, it is used for hypertension, vegetative-vascular dystonia, cervical osteochondrosis, after brain injuries, heart attack, stroke and other diseases. It should be taken into account that acute/subacute conditions are contraindications for taking MP. Moreover, she herself was treated with medication for essential hypertension. Negative symptoms disappeared after 6 days of therapy. Lightness appeared and my mood lifted. The medicine is effective and inexpensive.

Side effects

If used incorrectly or if the interaction of drugs with each other has not been taken into account, the following side effects occur:

• Nervous system: Weakness;
• Dizziness;
• Sleep disorders;
• Headache.

Cavinton increases blood pressure only if an adverse reaction occurs. Normally, after using the drug, it decreases slightly.

Analogs

Diseases for selection

Doesn't interact with

Here you can add diseases and medications so that the Cyberis artificial intelligence selects analogues that do not have dangerous contraindications or interactions with the drug administered.

Despite the high effectiveness of Cavinton, many people prefer to choose its analogues. Why is this happening? There are analogs of Cavinton that have:

• lower cost;
• fewer contraindications;
• fewer side effects;
• wider spectrum of action;
• other forms of release.

When deciding to search for similar drugs, it should be taken into account that Cavinton is available in the following dosage forms:

• 5 mg tablets, 50 pieces in a package;
• concentrate for preparing the solution, 10 ampoules per pack.

Tablets cost about 200 rubles, while the concentrate will cost about 250-300 rubles.

• The online medical service is designed to select the optimal replacement for medications.
• Find cheap analogues for expensive drugs.
• For drugs that do not have complete analogues, look at the list of drugs that are most similar in use.
• If you are a professional, then the help of artificial intelligence will help you select treatment.

Contraindications and precautions

These include:

• Hemorrhagic stroke in the acute stage
• Severe coronary heart disease
• Severe cardiac arrhythmia
• Phenylketonuria
• Periods of pregnancy and breastfeeding
• Minors under 18 years of age
• Intolerance or excessive hypersensitivity to the components of the medication.

Cross-drug interactions

Methyldopa in combination enhances the hypotensive effect, so you need to monitor your blood pressure. Should be taken with caution with anticoagulants and antiarrhythmic drugs.

Side effects

Sides of the visual organs: rarely - swelling of the optic nerve head, even less often - redness of the conjunctival sac.

Immune system: rarely – hypersensitivity to the drug.

CNS: euphoria, insomnia, depression.

Heart: ischemia, arrhythmia, increased blood pressure.

Gastrointestinal tract: diarrhea, abdominal pain.

Other: allergies, rash, hives, weakness, feeling of heat in the body.

Overdose

There is no specific data, but if there is suspicion, then symptomatic treatment with mandatory gastric lavage is needed.

The use of Cavinton is prohibited in the following situations:

• Intolerance to the main active ingredient;
• Serious heart rhythm disturbances;
• Cardiac ischemia in an advanced stage;
• Acute stroke with cerebral hemorrhage;
• Allergy to lactose.

It is not recommended to use the medication during pregnancy and breastfeeding. This is due to the fact that the effect of the drug on the child is not fully understood. This nuance also applies to children under 18 years of age.

Contraindications, side effects and overdose

The drug for improving blood circulation in the brain, despite its effectiveness, has a small list of absolute contraindications:

• intolerance to the medicinal substance or any component of Cavinton, acute reaction to lactose (for tablets);
• hemorrhagic stroke;
• hemophilia, low blood clotting, tendency to hemorrhage;
• severe cardiac ischemia and arrhythmias;
• period of gestation and breastfeeding.

Relative contraindications include an age limit of 18 years (studies on the effect of the drug on patients in the child and adolescent category have not been conducted). Most specialists actively prescribe medications from the age of 14.

Restrictions when prescribing Cavinton apply:

• for patients receiving medications to lower blood pressure with Vinca minor alkaloids, for example, Vincamine, Vincapan, and for persons with special sensitivity to them;
• for persons taking medications that increase the QT interval (including amiodarone, dofetilide, thioridazine, clarithromycin, erythromycin, chlorpromazine, haloperidol, amitriptyline);
• for patients with liver failure.

Side effects of vinpocetine include:

• in 1–10 patients out of 1000 - nausea, heartburn, dry mouth, headache, dizziness, weakness, decreased blood pressure;
• in 1–10 patients out of 10 thousand - itching, rash, hot flashes, drowsiness, nervousness, constipation or diarrhea, thrombophlebitis, decreased appetite, sleep disturbances, taste disturbances, hearing disturbances, increased or decreased heart rate;
• in isolated patients - diabetes mellitus, myocardial ischemia, angina pectoris, anemia, overexcitation, depression, spasmodic muscle contractions, redness of the eye mucosa, atrial fibrillation, dermatitis, weight gain.

There is no reliable and complete data on an overdose of Cavinton, but, according to experts, with single or long-term use of increased doses, one should expect the appearance or intensification of adverse reactions characteristic of vinpocetine.

Cavinton: instructions, price, reviews and analogues

Cavinton solution and tablets are used in the treatment of various pathological processes; the drug is more often used to treat neurological disorders:

• Disruptions in the cerebral circulatory system of acute and chronic course, due to stroke, dementia caused by multiple heart attacks, transient ischemia, etc.
• Neurological and mental disorders, manifested in the form of headaches, dizziness, problems with movement, impaired memory, VSD (vegetative-vascular dystonia), etc.;
• Manifestations of climacteric syndrome (menopause).

The medication is also prescribed for the treatment of various eye diseases:

• Pathologies of the eyeball associated with blockage of blood vessels (atherosclerosis, thrombosis, embolism) and their spasm (angiospasm);
• Serious disorders of the structure and function of the retina, as well as the choroid and macula;
• Secondary glaucoma caused by injury, inflammation, or partial blockage of the eye vessels.

Cavinton is sometimes used in the treatment of ear pathologies:

• Cochleovestibular neuritis;
• Decreased hearing acuity caused by the influence of toxins, vascular pathologies, etc.;
• Age-related hearing loss;
• Meniere's disease;
• Dizziness and tinnitus caused by problems in the labyrinth (inner ear).

Margarita, 32 years old, Solntsevo: “After suffering a stroke, my grandfather began to hear poorly. Problems with memory appeared, to the point that my grandfather might not recognize his relatives. The neurologist prescribed Cavinton soluble tablets. A month after the start of therapy, the condition began to improve. The drug has a convenient release form. The tablet quickly dissolves in water, forming a suspension.”

Nina, 63 years old, Moscow: “With age, vascular disorders appeared, due to which my hearing began to deteriorate. The doctor recommended a course of treatment with Cavinton Comforte. The medicine dilates blood vessels and normalizes blood flow in the brain. After a 3-month course, my hearing began to return, and the dizziness disappeared.”

Cavinton comfort - film presentation of the drug Cavinton: instructions for use

The approximate price for Cavinton comfort (30 or 90 tablets) is 287–306 or 595–648 rubles.

Prescribing Cavinton comfort to patients under 18 years of age is contraindicated.

Dispensed from pharmacies with a doctor's prescription.

The drug is contraindicated for use during pregnancy, because Vinpocetine penetrates the placental barrier. Moreover, its concentration in the placenta and in the blood of the fetus is lower than in the blood of a pregnant woman. At high doses, placental bleeding and spontaneous abortions are possible, probably as a result of increased placental blood supply.

Within an hour, 0.25% of the administered dose of the drug passes into breast milk. When using Cavinton, breastfeeding should be stopped.

The methods of using various drugs containing vinpocetine are similar. The difference between drugs lies in the dose of the active substance.

Side effects

Overdose

Indications

The medicine is often used in such areas of medicine as:

• neurology;
• ophthalmology;
• otolaryngology.

Neurology:

• dizziness;
• encephalopathy;
• vegetative manifestations of menopause;
• vertebrobasilar insufficiency;
• stroke;
• apraxia;
• atherosclerosis of cerebral arteries;
• speech dysfunction;
• weakening of memory;
• cognitive impairment;
• motor dysfunction.

Ophthalmology:

• visual impairment due to embolism, vasospasm, glaucoma, disorders in the ocular vessels, atherosclerosis, thrombosis of the ocular vessels.

Otolaryngology:

• dysfunction of the vestibular apparatus;
• age-related hearing loss;
• noise in ears;
• Mignard's disease;
• hearing loss.

Release forms and dosage

The duration of treatment and dose are determined by the attending physician.

Cavinton Comforte tablets are taken orally after meals; you can swallow them whole with a little water; if swallowing is difficult, the tablet should be placed on the tongue for resorption. If the patient likes the orange flavor of the dispersible tablets, they can be dissolved in the mouth.

The daily dose of the drug is 30 mg (1 tablet of 10 mg 3 times a day). The therapeutic effect develops approximately a week from the start of taking the drug.

For kidney and liver diseases, no dose adjustment is required.

Pharmacokinetics

When taken orally, it is rapidly absorbed. Has a bioavailability of 60-70%. Maximum fills the blood plasma approximately an hour after use. The elimination period is 5 hours. Caviton is excreted in the urine in the form of metabolic products. Saturation in plasma is about 15-20 ng/ml. Has the property of passing through the placenta. Biotransforms in the liver to the state of hydroxyapovinamic acid.

Mechanism of action:

• Selectively improves the blood supply to the brain.
• Improves microcirculation and hemorheological norms.
• Enhances the processing of glucose by brain tissue and supplies it with oxygen.

Side effects:

• Lowers blood pressure.
• Sometimes - extrasystole, increased heart rate.

Interaction with other drugs - while using heparin, the possible risk of bleeding increases.

Directions for use and dosage:

1. Solution for injection - intravenously.
2. Tablets - orally after meals.

What is the difference between Cavinton Comfort and Cavinton Forte

Recently, vascular disorders have been spreading, which leads to tissue hypoxia. The central nervous system suffers most from this phenomenon. The drug Cavinton Comforte is intended for the treatment and prevention of ischemia.

It has antihypoxic, cerebroprotective, antioxidant and antiplatelet properties. The use of the drug is advisable during the recovery period to eliminate the consequences of cerebrovascular diseases and brain injuries.

The therapeutic effect of the drug is due to the properties of the active component – ​​vinpocetine. The neuroprotective effect consists of weakening the toxic effects on brain cells of reactions occurring due to stimulation by amino acids.

The product also accumulates the protective effects of adenosine. It provides the brain with the main energy substrates - oxygen and glucose. Strengthens their transport and uptake by cells, and includes them in metabolic processes. Significantly increases cAMP content due to phosphodiesterase inhibition.

Prevents the occurrence of hypoxia and improves microcirculation in the central nervous system. Thanks to its antioxidant activity, it binds free radicals and their cytotoxic effects. Vinpocetine acts as an antiplatelet agent and improves the rheological properties of blood.

Able to increase cerebral cardiac output fraction without robbing ischemic zones.

The antihypoxant Cavinton Comforte contains the active ingredient (vinpocetine) and auxiliary components. The drug is intended for oral administration and is produced in the form of tablets that dissolve in the mouth.

Use for encephalopathies helps stop the progression of the disease.

The drug is also effective for the treatment of vascular diseases of the organs of vision and hearing (retinopathy, retinal vascular occlusion, sensorineural hearing loss, tinnitus).

You must follow the instructions for using Cavinton Comforte tablets to prevent unwanted effects. Side effects include heart rhythm disturbances, agranulocytosis, insomnia and decreased appetite.

One of the contraindications is phenylketonuria, since the product contains a source of phenylalanine.

It is also worth noting individual intolerance to components, severe cases of ischemic heart disease and arrhythmias, the period of lactation and childbearing.

The substance is able to cross the placental barrier and enter the fetal bloodstream. An undesirable increase in blood flow in the placenta may also occur, which threatens miscarriage.

These properties of the drug make its use dangerous for the body of a pregnant woman and child.

During use, you must stop breastfeeding, since the drug passes into mother's milk.

Cavinton Comforte is prescribed 1 tablet 3 times a day. The maximum daily dose should not exceed 30 milligrams. Improvement occurs a week after the start of therapy.

Before taking Cavinton Comforte tablets, you should consult a doctor who determines the duration of the course and dosage, also warns about possible adverse reactions and checks for contraindications. There is no data on the effect of the drug on attention and the ability to drive a vehicle.

When alcohol enters the bloodstream, it penetrates the brain cells and has a toxic effect. The drug increases the delivery of oxygen to tissues; when taken together, the body uses the entire O2 supply to utilize the metabolic products of alcoholic beverages and such therapy will not be effective. Therefore, when using the drug, you must avoid alcohol.

Cavinton Comforte, when interacting with methyldopa, enhances the hypotensive effect, therefore, if this combination is necessary, blood pressure levels should be monitored. The drug may enhance or suppress the pharmacological effect of other substances. Therefore, any combinations should be monitored by the attending physician and selected individually.

Failure to comply with the recommended dosage can lead to harmful consequences for the body. If you feel unwell, you should stop taking the drug and seek medical help. Detoxification measures include gastric lavage, taking sorbents and symptomatic medications.

Vinpocetine is also an active ingredient in a number of other drugs: Vicebrol Forte, Neurovin, Oxopotin. Glycine, Bifren, and Axotilin exhibit similar pharmacological effects.

Cavinton Comforte is available in many pharmacy chains. Distribution is permitted only by prescription.

Cavinton Comforte is often prescribed by doctors in the complex treatment of vascular disorders. It has declared itself as an effective method of combating oxygen starvation of the body. Patients note an improvement in their general condition and increased performance. The product is well tolerated and produces the expected effects.

The medicine must be stored in a dry, dark place out of reach of children. The temperature should not exceed 30 degrees. Suitable for use 2 years from the date of production.

Cavinton comfort is a medicine that improves blood circulation and brain metabolism.

A drug that improves blood circulation and brain metabolism - vinpocetine (vinpocetine)

Dispersible tablets are white or almost white, round, biconvex, with “N83” engraved on one side.

Excipients: mannitol - 75.6 mg, pregelatinized corn starch - 38 mg, butyl methacrylate copolymer - 9 mg, low-substituted hyprolose - 8 mg, crospovidone - 8 mg, magnesium stearate - 2.

85 mg, sodium stearyl fumarate – 2.8 mg, colloidal silicon dioxide – 1.6 mg, aspartame – 1.28 mg, stearic acid – 1.26 mg, sodium lauryl sulfate – 0.9 mg, dimethicone – 0.39 mg, orange flavor – 0.

32 mg.

15 pcs. – blisters (2) – cardboard packs. 15 pcs. – blisters (6) – cardboard packs.

The mechanism of action of vinpocetine consists of several elements: it improves cerebral blood flow and metabolism, and has a beneficial effect on the rheological properties of blood.

Increases tolerance to hypoxia: increases the transport of glucose, the only source of energy for brain tissue, across the BBB; shifts glucose metabolism towards the energetically more favorable aerobic pathway. Selectively inhibits Ca2-calmodulin-dependent cGMP phosphodiesterase.

Increases the exchange of serotonin and norepinephrine in the brain, stimulates the noradrenergic neurotransmitter system and has an antioxidant effect.

Improves microcirculation in the brain by inhibiting platelet aggregation, reducing pathologically increased blood viscosity, increasing the deformability of erythrocytes and inhibiting the reuptake of adenosine; promotes the transition of oxygen into cells by reducing the affinity of red blood cells for it.

Suction

Vinpocetine is rapidly absorbed after oral administration and reaches Cmax after 1 hour. Absorption occurs mainly in the proximal intestine. It is not metabolized when passing through the intestinal wall.

Distribution

In preclinical studies of oral administration of radioactively labeled vinpocetine, it was detected in the highest concentrations in the liver and gastrointestinal tract. Cmax in tissues is observed 2-4 hours after oral administration.

The amount of radioactive isotope in the brain did not exceed that in the blood. Protein binding in the human body is 66%. Vd is 246.7±88.5 l, indicating significant tissue binding. Bioavailability when taken orally – 7%.

The duration of the therapeutic course is determined by the type of disease and the individual characteristics of the body.

The effect of the drug begins 7 days after the start of treatment. Soluble tablets can be dissolved or swallowed whole with a small amount of water.

The tablets can be taken with a small amount of water.

Patient reviews

Sofya Rukobaeva, 64 years old, Kostroma

I have been using the drug for several years now. The doctor prescribed it in combination with other medications to stabilize blood circulation in the brain tissue. I noticed that the cost of the drug increases every year, which does not surprise me at all, because it is extremely effective and rarely causes adverse reactions. As an elderly person, I completely trust this medication.

Petr Ilyin, 35 years old, Cheboksary

When I started having a “whistle” in my ear, the doctor prescribed these pills to solve the problem. The discomfort began to subside on the first day after the start of treatment. After 3-4 days, the discomfort disappeared completely. I didn't expect such a quick result. The sick leave never lasted until the end, so I left 5 days earlier to earn more money.

Alexandra Samoilova, 42 years old, Tver

My dear aunt uses the drug to improve her memory. She lives in Spain. It is impossible to find the medicine there, so every time I send it to her using an international courier service. The aunt said that a similar effect of the drug is achieved by improving cerebral circulation. By local standards, the medicine is inexpensive, and its price doesn’t really hit my wallet. I'm already thinking about testing it on myself.

special instructions

Before you start taking Cavinton tablets, you must carefully read the instructions for the drug. There are a few special instructions that you should pay attention to, these include:

• The presence of changes in the electrocardiogram in the form of prolongation of the QT interval requires periodic monitoring of the functional activity of the heart.
• One Cavinton tablet contains about 41 mg of lactose, which must be taken into account by persons with impaired breakdown and absorption of carbohydrates.
• Fructose intolerance is grounds for discontinuation of the drug.
• The drug does not affect the speed of psychomotor reactions and the ability to concentrate.