Psychiatry Psychiatry and psychopharmacotherapy named after. P.B. Gannushkina — Prediction of the therapeutic response to the use of the anxiolytic Afobazole for anxiety disorders: results of comparative

In the modern rhythm of life, people are often exposed to stress . There can be a great many reasons for this: family problems, problems at work, etc. Many people try to cope with stress and panic attacks on their own. However, this does not always work out. Then you have to resort to taking medications. Popular ones are Phenazepam and Afobazole . When faced with the need to take such medications, people wonder which one is best? To do this, it is necessary to compare drugs.

Effect of Phenazepam for panic attacks

The pharmacological action of the drug works in three main directions:

  • sleeping pills: reduces the degree of exposure to external irritants that affect sleep;
  • sedative: eliminates the appearance of feelings of panic, fear and anxiety;
  • anticonvulsant: removes a negative impulse without affecting the cause of its occurrence.

Medical treatment

Phenazepam does not completely eliminate the disease, but fights the symptoms. At earlier stages of panic attacks, sedatives may be used; if the disease progresses and the symptoms become more pronounced, the doctor prescribes Phenazepam.

Recommendations for use during a panic attack

The drug is supplied in tablet form and solution. The tablet is placed under the tongue during a panic attack or (to speed up the action) washed down with a small amount of water. In emergency cases, solutions are used to prepare injections. Thus, the product reaches the source of action as quickly as possible.

After a course of treatment with Phenazepam, it is necessary to change the drug or take a break. The reason is addiction to the medicine, and therefore it is possible to gradually increase the dosage to achieve a therapeutic effect.

How does Afobazol work?

Afobazole is a tranquilizer of a non-benzodiazepine structure, characterized by a moderate tonic effect combined with the relief of anxiety. Unlike benzodiazepines, the drug has a mild effect, is not addictive and does not have a sedative effect. The drug affects the brain neurons responsible for anxiety, but does not depress the central nervous system. The main effects of taking the pills:

  • elimination of anxiety disorders of various origins;
  • improved mood;
  • increased attention;
  • activation of the central nervous system;
  • improved sleep;
  • relief of symptoms of VSD and somatic manifestations of anxiety.

The drug is taken over a long course; after treatment, withdrawal syndrome does not develop.

Attention! Afobazole does not affect concentration; you can drink it while driving and during difficult work. Read more about the composition and action in this article.

Indications for use

Phenazepam is used to relieve symptoms of various diseases. Among them:

  • panic attacks;
  • insomnia;
  • phobias of various origins;
  • epileptic seizures;
  • convulsive conditions;
  • psycho-emotional instability;
  • severe psychoses.

The main purpose is sedative, hypnotic, anticonvulsant.

Dosage

The dosage of this drug is prescribed strictly by the doctor. It is determined by the patient’s condition, the presence of symptoms and their intensity.

In the standard regimen, treatment begins with 1 tablet; if necessary, the dosage is increased to achieve a therapeutic effect, but it is not recommended to do this on your own. Otherwise, an overdose may cause problems with memory, coordination, and frequent dizziness.

Overdose

If an overdose of Phenazipam occurs, patients usually experience the following symptoms: drowsiness, deterioration of reflexes, decreased blood pressure, shortness of breath, and bradycardia.

In case of overdose with Phenazipam, it is recommended to use activated charcoal or gastric lavage. After all of the above, flumazenil can be administered.

Phenazepam contraindications for panic attacks

Despite the fact that the drug contains substances that have a calming and stabilizing effect, it is not prescribed for:

  • pregnancy and during breastfeeding;
  • the presence of intolerance to the components of the active substance;
  • state of coma or severe shock;
  • myasthenia gravis (muscle pathology);
  • problems with the respiratory system;
  • presence of predisposition to glaucoma.

Phenazepam is contraindicated for use in children under 18 years of age; it should be used with caution in old age. All features of treatment and use must be taken into account by the attending physician.

Is it possible to take Novo-Passit and Phenibut together?

Pharmacologically, the drugs are compatible and enhance each other’s effects, so they can be taken simultaneously. It should be taken into account that Novo-Passit is contraindicated for injuries and diseases of the brain, so it can be taken together with phenibut only in cases of impaired brain function, when its structure does not suffer:

  • vegetative-vascular dystonia with panic attacks;
  • depression and neurasthenia that cannot be corrected with one drug;
  • insomnia of various origins;
  • disruption of memory processes, inability to concentrate, inattention due to prolonged mental or mental stress;
  • exhaustion of the nervous system, severe fatigue due to stress.

During treatment with Phenibut and Novo-Passit, you should not drink alcohol (they enhance its effect) and engage in potentially hazardous activities, including driving a car. Sometimes it may be necessary to adjust the dose of medications, but such recommendations can only be given by a doctor, based on the specific situation.

Source: generic-forum.ru

It is important to understand that pharmacology does not eliminate the causes, but only relieves the symptoms, therefore, when treatment is stopped, the symptoms return. And the second important thing is that the stronger the medicine, the more addictive and side effects there are.

The simplest anti-anxiety remedies are various natural herbal remedies, motherwort, valerian, mint, etc. Sold at any pharmacy without a prescription.

Stronger drugs are tranquilizers; a neurologist or psychiatrist can prescribe them. Tranquilizers can be divided into two groups: benzodiazepines and non-benzodiazepines. NON-benzodiazepines are less effective in relieving anxiety, but they do not cause addiction, which means you can drink them for a very long time without fear of consequences, so it is preferable to try them first, and then if it doesn’t help, then switch to benzodiazepines. The non-benzodiazepine group includes STRESAM, AFOBAZOL, ATARAX, etc. The active ingredients in these drugs are different, so one drug is more suitable for some and another for others. The most powerful of this group is atarax, but at the same time it is weaker than any benzodiazepine tranquilizer. The benzodiazepine group includes PHENAZEPAM, CLONAZEPAM, ALPRAZOLAM, etc. It is not recommended to take drugs in this group in a course due to the development of addiction, but they are very good for one-time anxiety relief in stressful moments.

example, once every three days. If you take it as a course, it is advisable that the course does not exceed 1 month. This group can also include nootropics with an anxiolic effect, such as phenibut, noofen, anvifen. These drugs are also addictive, so it is not advisable to take them in long courses. It is advisable that the course does not exceed 1 month. Doctors usually prescribe according to the 1t regimen. 3 times a day, but this is a fairly large dose for sensitive people, so try first taking half a tablet 2 times a day, look at the effect, and if the effect is not enough, then increase the dose. This group also includes the foreign drug GABA, which can be bought without a prescription on the website ru.iherb.com; more details about this will be in the message below.

An even stronger regimen is antidepressants (AD) or antipsychotics, or both. This regimen is prescribed by both neurologists and psychiatrists (some neurologists may not prescribe antidepressants and refer you to psychiatrists). There are many problems with antidepressants, firstly, they do not act immediately and it takes some time for the active substance to accumulate in the body, secondly, some antidepressant may not suit you individually and then you need to change it to another (and find out that it is not for you you will be able to do so only after a month of taking it), thirdly, antidepressants can give strong side effects, especially at the beginning of use. Well, when you stop taking it, a so-called “withdrawal syndrome” occurs, which is accompanied by various unpleasant sensations. When you start taking antidepressants, the first two weeks almost always cause unpleasant side effects, so at this time it is very advisable to drink something to improve the condition, for example, atarax, or some kind of painkiller, if you have headaches, if the side effects are severe, you can add phenibut or phenazepam.

Also, to reduce side effects, it is better to start the course with small doses, and gradually gradually increase them as you get used to it. Let's say 5 days 1/4 tablet, 5 days 1/2 tablet, 5 days 3/4 tablet, etc. More details about antidepressants are written below.

Among the antipsychotics, I would highlight TERALIGEN, it has few side effects, but the truth is that the effect is weaker compared to others.

The optimal treatment regimen that I recommend for mild cases is something like ATARAX/PHENIBUT/TERALIGEN plus work with a psychologist. IF YOU DO NOT WANT TO WORK WITH A PSYCHOLOGIST, THEN IT IS BETTER TO CONTACT A PSYCHIATTER/NEUROLOGIST AND START A COURSE OF AN ANTIDEPRESSANT. It is advisable to take antidepressants for at least six months. Well, according to statistics, when an antidepressant is discontinued, in 80% of cases the problem returns within 5 years, so to prevent this from happening, you need to work with a psychologist during the course.

Source: vk.com

Hello, Anatoly! My name is Ekaterina, I’m 32 years old, I’m from the near Moscow region. For the second year now I have been taking phenazepam no more than one tablet a day. In 2011, I had my first panic attack on the street, then at home. The ECG during the attack showed only sinus tachycardia. My blood pressure always rises to 150 due to nervous tension.

At the ambulance they gave me phenazepam under the tongue, Corvalol and valerian. They said that nerves and hidden emotions . I always keep everything to myself, but I had enough stress. So the vegetation “limped”. My brain remembered my first PA, and off we went. Now I even have a phobia of the blood pressure monitor; when I pump air into it, my pulse is already under 120. That’s why I haven’t measured my blood pressure for six months. But my stable has always been 115 to 75.

I haven't had a panic attack for eight months now. But after them there was an unpleasant feeling in the area of ​​the apex of the heart, like emptiness, or a tugging, or a feeling of some kind of non-existence. This is felt only at rest; if you go for a run, do physical work, it all goes away. I probably already have cardioneurosis.

For six months I drank afobazole, persen, novopassit, tenoten, relaxosan, glycine forte, magnesium B6, Corvalol, valerian, read Kurpatov, read the entire website about VSD. NOTHING HELPED. As soon as I take phenazepam, it seems to me that I am “healthy”. And this discomfort in the left side of the chest of a psychogenic nature, as the psychotherapist told me, I can only relieve with phenazepam. I read your article “Withdrawing Phenazepam” and lasted five days without the medicine. On the fifth day in the morning, my whole body felt unpleasant, as if my blood pressure had dropped and I felt terrible weakness.

And then fear appeared again, my heart began to beat, and blood rushed to my head. I took phenazepam under my tongue, and after an hour everything went away. I probably already have endogenous depression , I’m suffering from cardioneurosis, and at the slightest excitement my pulse quickens.

The psychotherapist advises taking Paxil. I haven’t tried it yet, they say there are all sorts of side effects, but it helps someone, I want to try it. After all, sometimes there was even such fear that I couldn’t go outside with the child. And now I can do everything, but only with phenazepam, and I drink it only because of this incomprehensible feeling in the heart area, this feeling is really bothering me.

But the most interesting thing is when you don’t focus on yourself and there is no feeling of it. I was very fixated on my condition. An incomprehensible fear, now I’m afraid to die, now I’m afraid of my heart, but it’s like a Swiss watch, it works and works, and I’m afraid. Life was divided into two parts, before and after panic disorder. So I’m taking phenazepam, I don’t know what to do? The panic disorder has gone away, but this feeling in the heart area remains, or it really is already depression. Maybe try Paxil? I will be grateful to you for your answer. Best regards, Ekaterina. (If I stop taking phenazepam, I will hardly be able to withstand bodily pain without it).

Answer to the question:

How to relieve tension in the nervous system?

From your story I understand that now the general condition is satisfactory. The panic attack is in the past, only minor discomfort in the heart area remains. But this is observed only under one condition. Constant use of phenazepam is required. But everything suggests that, despite taking a tranquilizer, the nervous system is experiencing overexcitation. Such strange phobias as fear of doctors, people in white coats, the sound of an ambulance siren and fear of a medical examination, even the most harmless one, indicate extreme tension in the nervous system.

There are two ways to relieve tension in the nervous system.

The first is taking psychotropic medications. You can take tranquilizers, such as phenazepam. But you need to take it regularly and constantly. The daily dose is small, the therapeutic effect is fast and there are minimal side effects. Although doctors and the instructions for the drug do not advise taking phenazepam for more than one month, most people with panic disorder are saved in this way. You are also on this list. Antidepressants have a slightly different effect on the human nervous system. A huge number of side effects, especially in the first weeks of treatment, when all the symptoms intensify. And as a result, after treatment, the disease remains with the person.

Therefore, you need to perceive psychotropic medications not as a means of eliminating panic disorder, but as an opportunity to give your nervous system a break for a while. Give her the opportunity to soberly assess her condition and work on eliminating her fears on her own. I have a negative attitude towards antidepressants.

The second way is to work with your own thoughts and attitudes. Why did you have an attack of PA after stopping phenazepam on the fifth day? Phenazepam has the property of accumulation in the body. It is on the fifth day that the concentration of the drug in the body decreases below the required therapeutic level, and the body is left without outside support. He remains on his own against his panic disorder. The fear of death begins to take precedence over everything else and everything returns to normal. You just need to accept the idea that a person does not live forever and come to terms with it. It sounds simple, but buried in this statement is an attitude towards the disease and the opportunity to recover. Only by coming to terms with your fear of death can you gradually recover. This is the only right direction. phenozepam under the tongue . Its action is the same when taken orally and sublingually.

And the conversation that you can’t stand it without phenazepam is a little exaggerated in your imagination, in your thoughts. Convince yourself of the opposite and everything will work out for you. Anyone who survives one panic attack is already a hero.

Source: vsd-lechenie.com

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