Mexidol analogues in tablets and ampoules, cheap drug substitutes

Mexidol is a Russian-made medicine that has no analogues in the West. A universal drug with a wide spectrum of action. It is prescribed mainly for various pathological conditions of the central nervous system. The action of the drug is mainly directed towards the nervous tissue.

Mexidol is an antioxidant, i.e. neutralizes the oxidative effect of free radicals and other compounds. Such substances can be formed during circulatory disorders in the carotid and vertebrobasilar areas of the brain or during intoxication with psychotropic substances. The drug also has a beneficial effect when:

• vegetative-vascular dystonia;
• neurosis-like states;
• cognitive disorders associated with atherosclerosis.

Pharmacological properties of Mexidol

Mexidol is prescribed both as a complex therapy and, together with other groups of drugs, effectively counteracts purulent-inflammatory processes, myocardial infarction, and open-angle glaucoma. Despite its proven effectiveness, Mexidol is sometimes replaced with analogue drugs, which are more effective in some pathological conditions.

Release form, composition

The medicine is available in the form of tablets and injections for both intramuscular and intravenous administration. Tablets with a dosage of 125 mg are available in blisters of 10 pieces, injections with a dosage of 50 mg/ml - 5 pieces in a pack.

The active substance in the composition is ethylmethylhydroxypyridine succinate, excipients are lactose monohydrate, magnesium stearate and povidate.

Why are they looking for drug analogues?

During manufacture, in addition to the main substance, auxiliary components are added to any drug. These include, for example, for tablet forms – binders, fillers and disintegrants, as well as coloring agents. Each company that produces analogues (generics or synonyms) introduces its own auxiliary components as additives. Their interaction with ethylmethylhydroxypyridine succinate, the main active ingredient, will also be different. And if in some cases of the disease it is better to use one drug, then in other cases an analogue may work better for the same patient.

Mexidol is practically not used as an independent drug. It is used in combination with other medications to enhance their effect. However, when using Mexidol, the following side effects may occur:

• the appearance of dizziness,
• drowsiness,
• dry mouth,
• increased temperature or, conversely, a feeling of chilliness;
• cardiopalmus,
• allergic reactions,
• high blood pressure.

Due to side effects, patients have to look for analogues. Some generics are cheaper. However, the main condition for the patient is that the analogue must have fewer negative side effects. The dosage forms of such drugs are different - tablets, capsules, solutions or dragees.

Indications for use

Intravenous and intramuscular injections are prescribed for:

• traumatic brain injuries;
• encephalopathy;
• VSD;
• acute circulatory disorders in the brain;
• neuroses, panic attacks;
• glaucoma;
• poisoning of the body with alcohol or antipsychotic drugs;
• peritonitis and pancreatitis.

The use of tablets is recommended if:

• asthenic syndrome;
• encephalopathy;
• anxiety states;
• alcohol intoxication;
• mild traumatic brain injury.

Opinions of doctors and patients about the medicine

Reviews of Mexiprim are mostly positive. Doctors note the pronounced effects of Mexiprim when the dosage is calculated correctly and used in accordance with the indications. According to their reviews and observations, taking the drug improves the general condition of patients, has a positive effect on cognitive skills when they are impaired, and allows them to more quickly cope with withdrawal symptoms.

Reviews from patients say that thanks to taking Mexiprim, their memory has improved and they can concentrate better. Those people who have used the drug on the recommendation of a doctor to treat sick elderly relatives also note a positive effect: patients become calmer, their brain activity improves, and sometimes skills lost due to brain disorders return.

Among the disadvantages of the drug, as some reviews note, are primarily the difficulty in calculating dosages, as well as the inability to use in the treatment of children.

How to use the drug?

There are a number of rules that must be followed when taking the medicine. This is necessary in order not to cause harm to the body.

Instructions for use

If the medicine is used intravenously, it must be diluted with an isotonic sodium chloride solution. The solution is injected slowly - over five minutes.

The rate of administration of a dropper with the drug is an average of fifty drops per minute. The maximum dose should not exceed 1200 mg per day.

Tablet dosage regimen

The dosage of the drug for intramuscular injection is selected individually.[BR][BR]Pill dosage regimen.

When taken orally, it is necessary to consume from 375 to 750 mg, tablets should be taken several times a day. The maximum course of treatment is one and a half months, provided that the body responds adequately.

If the drug is taken after a long binge, the maximum period of use is one week.

Important! You cannot abruptly stop taking the drug; you must gradually reduce the dose over three days.

Popular substitutes in tablets

Today, not only injectable analogues of the drug Mexidol are produced, but also cheaper drugs with a similar effect in tablets: Actovegin, Glycised, Cavinton, Nootropil and Tenoten. The advantages of these drugs are considered to be an easier route of administration and a long-lasting effect.

Glitsed

Glycised is a domestically produced drug based on glycine. Glycine is a natural inhibitory metabolite, therefore it penetrates well into all human tissues and organs and has a minimum of side effects.

Glicised is used in the treatment of neuroses and neurosis-like diseases, strokes and encephalopathies. Not prescribed for children under three years of age, pregnant women and patients suffering from arterial hypertension. Take the medication 1 capsule 3-4 times a day. For the treatment of sleep disorders, 1 capsule (100 mg) is prescribed 20 minutes before bedtime. Adverse reactions include:

• dyspeptic disorders;
• dermatological manifestations of allergic reactions;
• headache;
• weakness.

Actovegin

The medicine contains a deproteinized hemoderivate, which is extracted from the blood serum of calves. Actovegin improves energy metabolism, the body's resistance to hypoxia and protects nervous tissue from ischemic damage. It is used in therapy:

• dementia;
• peripheral circulatory disorders;
• polyneuropathy (with diabetes);
• vascular diseases (venous trophic ulcer, arterial angiopathy).

Mechanism of action of Actovegin

Side effects: increased heart rate, increased or decreased blood pressure, myalgia, tremor, sensitivity disorders, vomiting, diarrhea, loss of consciousness, acrocyanosis. Actovegin is used intravenously, intramuscularly and orally, with the initial dose being 20 ml and the maintenance dose being 5 ml. For arterial angiopathy, the dose is doubled, and for polyneuropathy, the initial dose is 50 ml. Cases of overdose have not been described.

Cavinton

Cavinton is a medicine with vinpocentine as an active ingredient. The drug is a psychoanaleptic and psychostimulant, improves blood supply to the brain and its metabolism. Used in several areas of medicine:

1. Ophthalmology. For the treatment of inflammatory diseases of the choroid and retina.
2. Neurology. For vascular pathologies of the brain of various origins (stroke, dementia, encephalopathy, atherosclerosis).
3. Otolaryngology. Treatment of hearing loss and tinnitus associated with vascular pathology.

Instructions for use of the drug

Not prescribed for patients with the acute phase of cerebral stroke, severe forms of arrhythmias, as well as during pregnancy and lactation. Can be used simultaneously with Glibenclamide, Hydrochlorothiazide, beta-blockers.

Cavinton is prescribed only intravenously as a bolus at a rate of less than 80 drops/min and must be diluted with a solution for infusion. Intramuscular administration is strictly prohibited.

Nootropil

Nootropil is a nootropic drug containing piracetam. The drug improves brain activity and cognitive abilities, increases memory, learning and concentration. Positively affects the metabolism of nerve cells and the rheological properties of blood. Prescribed for the following pathological conditions:

• Alzheimer's disease;
• withdrawal syndrome in alcoholism;
• psychoorganic syndrome in elderly patients;
• psychoorganic syndrome in children, which is manifested by a decrease in the level of learning;
• sickle cell anemia;
• myoclonus;
• attacks of dizziness.

Action of Nootropil

The dose varies from 20 to 160 mg/kg. For the treatment of ischemic stroke, the standard dose is 4.8 g/day. The most common side effects are:

• nervousness;
• irritability;
• asthenia;
• depression;
• increased drowsiness.

Contraindications to prescribing the medication are: age under 1 year, renal failure and individual intolerance. Use with caution in patients with impaired thrombotic function of the blood, during surgical interventions and massive bleeding.

Tenoten

Tenoten is a homeopathic remedy that has anxiolytic and sedative effects. It has virtually no contraindications or side effects, except for individual intolerance to the active substances.

The drug is used for the complex treatment of neuroses, stress and autonomic disorders and anxiety. Prescribed orally 1-2 tablets 2 times a day. The course of treatment is 1-2 months. The last dose is no later than 2 hours before bedtime.

The effectiveness of the drug is quite controversial, so it is not recommended to use it as monotherapy.

"Mexidol": analogues

Like any other drug, Mexidol has many analogues with similar effects.

Analogues of "Mexidol" (in tablets)

Mexidol analogue in tablets:

• Mexico;
• Medomexy;
• Armadin;
• Glycised;
• Antifront;
• Actovegin.

The price category of these analogues varies from 75 to 1700 rubles.

Analogues of the drug "Mexidol" (injection solution)

Mexidol analogue in ampoules:

• Cortexin;
• Instenon;
• Mexico;
• Mexicofin.

The doctor chooses the appropriate remedy, the price of the drugs is from 280 to 2800 rubles.

Cheap generics

Release form of generics - as injection solutions or tablets:

• Mexidant - eliminates panic attacks, improves memory;
• Nootropil - prescribed for the treatment of people suffering from alcohol addiction, combats memory problems;
• Cerecardium - acts as an antioxidant, restores tissue damage;
• Cavinton - improves cerebral circulation, thins the blood;
• Mexiprim - relieves anxiety and restlessness.

The price of drugs ranges from 150 to 300 rubles.

Russian analogues

Among the Russian analogues of the medicine we can mention:

• Mexico;
• Mexicofin;
• Mexiprim;
• Neurox;
• Cerecard.

The action of the drugs is aimed at improving cerebral circulation, combating nervous conditions, as a therapy for VSD, encephalopathy. These drugs are inexpensive - from 160 to 300 rubles. Taking the product is prohibited during breastfeeding, pregnancy and allergic reactions.

Close substitutes of Ukrainian production

Ukrainian products have also shown their effectiveness in the therapy process; they correspond to the characteristics of Mexidol:

• Armadin;
• Glycised;
• Venokor;
• Dinar;
• Nikomex.

Ukrainian analogues cost from 80 to 420 rubles, and they have a positive therapeutic effect in acute heart disease, purulent inflammation of the stomach, relieve intoxication after heavy drinking, and restore body tissues and cells.

Belarusian synonyms of Mexidol

The Belarusian manufacturer also offers a number of analogues:

• Mexibel;
• Neurotropin;
• Pyracesin.

The price varies from 100 to 600 rubles, the action of the drugs is aimed at treating heart attacks, neurosis-like conditions, improving brain activity, and are used for head injuries.

Important! Taking medications is prohibited until the age of eighteen, during lactation, pregnancy and intolerance to the components.

Modern analogues of imported production

Imported drugs similar in composition and spectrum of action:

• Biotropil. It contains piracetam, which can successfully combat cognitive disorders and restore memory. The use of the drug for stroke is prohibited;
• Nootropil. Prescribed after injury to the skull, for the treatment of neuroses and alcoholic syndromes. The drug is suitable for therapy if there is no hypersensitivity to the active substance;
• Keltican. It is used to combat ringworm, neuralgia, joint inflammation, and helps in the fight against intoxication after long binges. Can cause allergies; allergy tests must be performed before use;
• Memory plus. The drug, created from natural ingredients, perfectly stimulates and develops thought processes.

The price category of the above-mentioned drugs is from 100 to 420 rubles.

The cheapest similar products

If you need to find a cheaper drug, you should pay attention to such drugs as: Mexicor, Armadin, Glycine, Astrox, Mexiprim. In some cases, analogs that are cheaper than Mexidol may be more effective than the main drug or completely identical in action.

Mexicor

Mexicor belongs to the group of cardiac drugs that affect cardiomycytes by inhibiting free radical processes. These processes occur during ischemia and necrosis of the heart muscle, and lead to disturbances in the contractile and excitatory functions of the myocardium.

Mexican action

Mexicor, acting as an antioxidant, helps preserve the cardiomyocyte membrane and stimulates the formation of enzymes necessary for its adequate functioning. It has a beneficial effect on metabolic processes in the myocardium:

• improves contractility of the heart muscle;
• increases coronary blood circulation;
• promotes the inclusion of compensatory mechanisms;
• stabilizes blood circulation in the brain basins.

Mexicor also improves cognitive abilities, which began to deteriorate due to vascular disorders, and has a positive effect on learning and memory.

The drug is prescribed in the form of capsules of 100 mg in 3 doses per day, or by injection twice a day. The medicine may cause insomnia or drowsiness, digestive tract disorders, allergic reactions, coordination problems, anxiety, irritability, swelling, and weakness. Not for use in children under 18 years of age.

Armadin

Armadin is an inhibitor of free radical processes in the body, as well as a protector of cell membranes. The drug improves the electrical activity and contractility of the myocardium during ischemia, and in addition:

• stimulates compensatory mechanisms;
• increases resistance to pathological processes;
• improves metabolism in the brain;
• reduces the level of low-density lipoproteins, which lead to atherosclerosis.

Biochemical basis of the action of Armadin

Indications for use are:

• traumatic brain injuries;
• vegetative-vascular dystonia;
• acute myocardial infarction;
• open-angle glaucoma;
• intoxication with psychoactive substances.

Not prescribed if the patient has renal or liver failure. May cause nausea, vomiting, diarrhea, drowsiness, palpitations, discomfort in the heart area. Before intravenous administration, 50 mg of Armadin is diluted in 200 ml of physiological NaCl solution.

Glycine

Glycine is a nootropic drug that improves cerebral circulation and therefore stimulates cognitive abilities. The main indication for use is a decrease in cognitive functions due to ischemic disorders, i.e. the drug may improve initially reduced levels of memory and learning. If there were no violations, the drug will not affect cognitive abilities in any way.

Properties of Glycine

Glycine is administered parenterally or sublingually. The maximum daily dose is 300 mg. Children over three years old are prescribed 1 tablet 2-3 times a day. Can be used as an additional remedy in the treatment of alcohol dependence, 1 tablet three times a day.

Astrox

Astrox is an antioxidant drug that is used as part of complex therapy for:

• neurocirculatory dystonia;
• cerebrovascular disorders;
• intoxication with psychoactive substances;
• encephalopathies.

Cardiopsychoneurosis

Contraindications for use: pregnancy, lactation, liver failure, hypersensitivity to the active substance. Treatment begins with a minimum therapeutic dose of 50 mg, and then increases until the desired effect is achieved. When administered by infusion, preliminary dilution in 200 ml of physiological NaCl solution is necessary.

May cause decreased salivation, vomiting, cardiac discomfort, rapid heartbeat, decreased ability to work, and irritability. You should not combine taking the drug with performing complex tasks that require increased concentration.

Mexiprim

Mexiprim is a heteroaromatic nootropic antihypoxant and membrane protector. The drug has anti-stress, muscle relaxant and anxiolytic effects, effectively reduces intoxication in the event of acute pancreatitis, and is prescribed for:

• anxiety disorders;
• impairment of cognitive functions;
• relieving withdrawal symptoms in people suffering from alcoholism;
• inflammatory processes in the abdominal cavity.

Pharmacological properties of antioxidants

It is taken orally, in the form of tablets, and is absorbed in the gastrointestinal tract within half an hour. The medicine is prescribed in doses of no more than 700 mg/day. It is excreted from the body in the urine within 4-5 hours after administration. Can increase the effectiveness of antiparkinsonian drugs and anxiolytics. Not for use in combination with other drugs. Symptoms of overdose are observed in the form of:

• hypotension;
• anxiety;
• temperature rise;
• tremor;
• dry mouth;
• headache;
• drowsiness.

Cheap generics

Generics (reproduced medicines) are drugs with a composition identical to the original. What is the difference from the original Mexidol:

• low price, no advertising and marketing costs;
• composition of the dosage form (excipients have been changed);
• less chance of buying a fake.

Table of cheap analogues of the drug Mexidol: