BUSPIRONE PEOPLE'S REVIEWS, doctors' reviews, negative and real, scam or truth, price in the pharmacy for 2020 18:25

Buspirone
(English: Buspirone, Latin: Buspironum) is a synthetic drug, chemically derivative of azapirones[1][2] and belonging to the group of tranquilizers (anxiolytics).[3][4][5] Used orally.[6]

Buspirone was first synthesized in 1968 at the Mead Johnson research laboratory for .[7] Buspirone was initially created as a new antipsychotic drug, but further studies revealed its low effectiveness in psychosis. But buspirone has proven effective in treating generalized anxiety disorder.

In 1986, the drug was approved by the FDA and became the first non-benzodiazepine drug to treat generalized anxiety disorder.[8]

Composition and release form

The drug is produced in the form of flat white tablets, there is a chamfer and a score. The tablets have an unexpressed specific odor. Packaged in blisters of 10 pieces. Composition of the drug per tablet:

Features of using the drug

If during lactation there is a need for therapy based on taking Buspirone, breastfeeding is temporarily stopped.

In case of dysfunction of internal organs, there are some restrictions. For example, if you have liver problems, you should be careful during treatment and constantly monitor changes that occur in your health. Contraindications are only severe disturbances in the functioning of the organ. The same applies to kidney function.

Regarding the prescription of drugs from different manufacturers, including the drug Buspirone Sandoz, reviews from doctors indicate the need to follow certain rules. When prescribing a medication, the specialist must take into account that this drug is not able to eliminate withdrawal symptoms resulting from taking benzodiazepines, and its prescription in such situations is not possible if the anxiolytic drug has not been gradually withdrawn before therapy.

Patients should be aware that Buspirone tablets may affect alertness, especially at the initial stage of therapy, so it is better to temporarily refrain from activities requiring special responsibility and increased concentration. Some tasks can be potentially hazardous to your health.

As for therapy with Buspirone, doctors' reviews of the drug are mostly positive. However, experts note that it must be prescribed correctly, only if there are appropriate indications and in optimal doses. It is worth noting that for tension and anxiety, which arise from the constant negative impact of everyday stressful situations, treatment with anxiolytics is usually not necessary.

When patients take Buspirone with different dosages, for example, Buspirone 10 mg, reviews display it as the use of an effective remedy. People who have been treated with this medication report that their doctor warned them to be careful with certain medications, such as oral contraceptives, medications for diabetics, medications to lower high blood pressure, medications for depression, and medications such as cardiac glycosides. , neuroleptics.

Moderate kidney and liver failure and cirrhosis require a reduction in standard doses. In these cases, people's reviews describe taking Buspirone Sandoz as a treatment that must be carried out under the supervision of a doctor. You should pay attention to the slightest changes in your health.

The drug is never prescribed to patients with epilepsy due to the risk of seizures. Such therapy for this category of patients is dangerous and must be carried out using other medications. Patients who frequently abuse medications and have a history of drug dependence should be treated under the strict supervision of a specialist (there have been no cases of dependence on Buspirone).

Studies have shown that Buspirone is ineffective for anxiety after 3-4 weeks of use, so there is no point in treating it for a long time. Due to the lack of information about the safety of the drug for children, it is not prescribed to persons under 18 years of age.

Treatment with different versions of the drug and the drug "Buspirone Hexal" is reviewed by some experts as ineffective therapy for the reason that problems with sleep, the appearance of irritability and anxiety are sometimes a sign of serious psychomotor disorders.

Pharmacological properties

Buspirone Sandoz is an anxiolytic drug for the treatment of anxiety, neuroses, which are accompanied by feelings of anxiety, tension, restlessness, and irritability.

The mechanism of action of the drug has not been fully established, but differs from the action of benzodiazepines (also anxiolytics).

Buspirone has a high affinity for presynaptic receptors and is a partial agonist of postsynaptic receptors in the central nervous system. Preclinical studies have established that the drug has an antidepressant effect and does not affect the functioning of benzodiazepine receptors or the binding of gamma-aminobutyric acid.

Compared to benzodiazepines, the drug does not have a muscle relaxant or anticonvulsant effect, is not addictive, and does not lead to withdrawal symptoms. Its effect develops gradually; after 7-14 days of administration, a therapeutic effect is observed, which reaches a maximum a month from the start of treatment. The drug is quickly and completely absorbed, reaching equilibrium concentration in plasma after 2 days.

Buspirone is intensively metabolized in the liver, has 4% systemic bioavailability, reaches maximum concentration in the blood 75 minutes after administration, and is 95% bound to plasma proteins. Its half-life is 2.5 hours, there is no accumulation. The pharmacologically active metabolite of the substance pyrimidinylpiperazine has less anxiolytic activity, but higher plasma levels and a long elimination period.

Up to half of buspirone and its metabolites are excreted in the urine per day, and up to 40% are excreted in the urine. If liver and kidney function are impaired, drug elimination is reduced. Absorption slows simultaneous food intake. The active component passes into breast milk; such penetration into the placenta is unknown. In old age, pharmacokinetics do not change.

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Indications for use

The drug is used for treatment during psychotherapy. The list of indications for use includes the following conditions:

• generalized anxiety disorder;
• panic disorder;
• autonomic dysfunction syndrome;
• as an auxiliary treatment for alcohol withdrawal syndrome;
• as an adjuvant treatment for depressive disorders.

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Directions for use and dosage

The manufacturer's instructions for Buspirone inform that the exact dose is determined by the attending physician on an individual basis. The standard regimen for the first stage of treatment involves prescribing a dosage of 5 mg, the frequency of administration is two to three times a day. Gradually, the volume of the drug is increased to 15-30 mg, maintaining a distributed dose. The limit for a single dose is no more than 30 mg, the maximum daily volume is 45 mg. For patients with kidney and liver dysfunction, the dosage should be reduced.

It is recommended to take the drug at the same time every day. The tablets must not be chewed; they must be taken with a sufficient amount of water. The duration of the therapeutic course is determined by the doctor. It is prohibited to take Buspirone for a long time without consulting a specialist. Simultaneously with the course of treatment, it is recommended to carry out sociotherapeutic and psychotherapeutic measures.

Reviews of buspirone

There are many reviews about this product from patients with different types of anxiety disorders. Most of them describe side effects. For example, these:

— After taking each 5 mg tablet, I begin to feel nauseous and dizzy. Against this background, of course, fears and even panic intensify. Then he lets go. But the feeling is disgusting. There is no desire to test it regularly, hourly.

— I took buspirone according to the regimen for a couple of days - everything was fine. I slept well, I even felt some kind of lift. But on the third night I had, it seems, all kinds of side effects. It was very bad and the doctor stopped the drug.

“The first two weeks I felt nervous and didn’t sleep well. There were attacks of dizziness. But somehow I survived. Then the side effects subsided. Gradually I began to feel that my condition was leveling out and becoming easier. There were no panic attacks during this time.

Although there are happy exceptions:

— Buspirone works great for me. No worsening of the condition. Well, you shouldn’t expect any improvement by the end of the month of taking it.

The action of this substance is complex and multifaceted. Of course, this is not a remedy that you can “try” at your own peril and risk. If your doctor prescribes you buspirone, find out in advance what to do if side effects occur.

Drug interactions

In the instructions for use, it is useful to study the drug interaction section of the drug:

1. Caution should be exercised when taking Buspirone simultaneously with antipsychotics, antidepressants, anticoagulants, oral contraceptives, cardiac glycosides, antihypertensives, and hypoglycemic agents.
2. Combinations of the drug with benzodiazepines, sedatives, and monoamine oxidase inhibitors are prohibited (possible hypertensive crisis).
3. Nefazodone, Erythromycin, Itraconazole, Diltiazem, Verapamil, Cimetidine, Rifampicin can increase the bioavailability of the active component.
4. Lofexidine, Baclofen, antihistamines, and Nabilone can enhance the sedative effect of the drug.
5. Ketoconazole, Ritonavir can inhibit the metabolism of buspirone, and increase it - Dexamethasone, Phenobarbital, Carbamazepine, Phenytoin.
6. Long-term simultaneous use of the drug with selective serotonin reuptake inhibitors and antidepressants can lead to exacerbation of attacks.
7. Buspirone increases the concentration of Haloperidol and Diazepam in the blood, increases the activity of liver enzymes when combined with Trazodone, and cannot be combined with alcohol.
8. Fluvoxamine can increase the level of the active component in the blood, and Warfarin can increase the prothrombin time.
9. During treatment, you should not take large amounts of grapefruit juice, because the incidence of adverse reactions increases.

Special instructions for the use of Buspirone Hexal

Not all anxiety conditions require treatment, as they may also be complications of physical or mental illness that require treatment for the underlying condition. Buspirone is not intended to treat withdrawal symptoms associated with benzodiazepine use; for this reason, before starting treatment with buspirone, you should gradually stop using anxiolytic drugs and only then proceed to therapy with Buspirone HEXAL. Pregnancy and breastfeeding Since there is no experience with the use of buspirone during pregnancy, the drug can be prescribed only with an established diagnosis and absolute indications for its use. In experiments on animals, the teratogenic effect of the drug was not revealed. Breastfeeding should be discontinued during treatment. Effects on driving vehicles or other complex machinery Buspirone may affect alertness and concentration, especially at the beginning of treatment. This fact must be taken into account by patients who are engaged in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Side effects

Buspirone therapy can lead to the development of side effects:

• dizziness, insomnia, drowsiness, nervousness, headache, increased fatigue, fainting, decreased concentration, irritability, depression, hyperkinesia, anxiety, hallucinations, dysphoria;
• nausea, dry mouth, burning tongue, diarrhea, xerostomia, constipation, flatulence, vomiting, increased or lack of appetite, bleeding from the rectum;
• anger, hostility, confusion, asthenia, claustrophobia, memory problems, apathy;
• blurred vision, redness, itching of the eyes, conjunctivitis, photophobia, increased intraocular pressure, glaucoma;
• joint, bone, muscle pain, numbness, paresthesia, impaired coordination of movements, tremor, myasthenia;
• skin rashes, sweating, sticky skin, hyperesthesia;
• fever;
• palpitations, tachycardia, chest pain, hypotension, hypertension, heart failure, myocardial infarction, bradycardia, cardiomyopathy;
• cerebrovascular accident, eosinophilia, leukopenia, thrombocytopenia;
• numbness, epileptic seizures, dysosmia, dyskinesia, muscle rigidity, dystonia, arthralgia;
• tinnitus, damage to the inner ear;
• sore throat, nasal congestion, pain in the pharynx and larynx, nosebleeds;
• frequent urination, enuresis, dysuria;
• galactorrhea, gynecomastia;
• anorexia;
• loss of voice, hiccups;
• disruption of the menstrual cycle and prostate function, loss of libido, amenorrhea, impotence, inhibition of ejaculation;
• cold sweat, urticaria, hematomas, alopecia, eczema, ecchymosis, acne, hyperhidrosis, skin flushing.

Cases of overdose

What signs of overdose occur when taking increased doses of Buspirone? Reviews from experts indicate the following manifestations: miosis, nausea, increased fatigue, dizziness, gastric dysfunction, vomiting.

In case of overdose, gastric lavage is performed, as well as monitoring of blood pressure, respiration and pulse. Treatment is symptomatic.