"Phenibut" and "Phenazepam": compatibility, indications for use, dosage

Compound

The composition of the drug includes:

• potato starch;
• microcrystalline cellulose;
• magnesium stearate;
• lactose;
• povidone.

The main active element is morpholinoethylthioethoxybenzimidazole dihydrochloride.

It stops the process of membrane-dependent changes in the ligand-dependent ion channel of the nervous system. This allows you to inhibit nerve impulses controlled by the main neurotransmitter of the brain.

It has an anxiolytic effect and a moderate sedative effect. It does not have muscle relaxant properties, as a result of which there is no negative effect on concentration and memory.

With long-term use of Afobazole, the substance morpholinoethylthioethoxybenzimidazole dihydrochloride does not cause dependence and is not accompanied by “withdrawal syndrome”.

The action of the drug is based on a combination of anti-anxiety and mild stimulating effects of morpholinoethylthioethoxybenzimidazole dihydrochloride.

A course of taking Afobazole allows you to:

• reduce the severity of anxiety or lead to its complete elimination;
• eliminate the feeling of unreasonable fear, constant worries, negative premonitions, panic attacks;
• reduce irritability, nervousness, fearfulness, anxiety, tearfulness;
• normalize the ability to relax and rest;

• restore the optimal sleep-wake cycle, overcome insomnia;
• eliminate negative muscular, vascular, respiratory, and gastric phenomena that occur due to stress;
• reduce vegetative reactions that accompany a patient with nervous overstrain (dizziness, increased sweating, a feeling of dry mouth and sweaty palms);
• eliminate cognitive disorders (difficulty concentrating, remembering a large flow of information).

According to clinical data, a positive effect when taking the drug is observed after a week-long treatment course.

Phenazepam or Afobazol – which is better to take?

Both drugs are tranquilizers. However, Phenazepam is a much stronger remedy, acting quickly and helping to eliminate panic attacks and calm the patient. At the same time, the medication has a huge list of side effects and is sold only by prescription.

Without being too afraid, you can drink it in a course, but not more than 10 days and in minimal dosages. Also, nothing special will happen if the reception is carried out sporadically.

Afobazole (unlike Phenazepam, created back in Soviet times) is a modern drug and copes well with anxiety conditions without causing addiction. However, it is effective only when taken systematically. The course duration is usually 2-4 weeks.

Phenazepam does not help against depression, which cannot be said about the second drug under consideration. As you can see, Afobazole, although weaker, still wins in comparison due to its harmlessness.

Price in pharmacies

How much Afobazol costs in a pharmacy depends on the region of sale.

In Moscow and the Moscow region, you can buy the medicine for an average of 360-420 rubles (60 tablets).

In St. Petersburg, a package of tablets will cost approximately 370 rubles.

It is sold without a prescription from a neurologist, but this is not the reason for the use of Afobazole in self-medication; therapy should be prescribed by a specialist.

Taking medications: pros and cons

The decision about which pills to take to get rid of panic attacks is made by your doctor. Tranquilizers or antidepressants are usually prescribed. But it doesn’t hurt the patient himself to know the positive and negative aspects of treatment using medications.

The positive thing is that medications are a fairly inexpensive method of getting rid of panic attacks. Tablets can quickly relieve symptoms, help overcome apathy, reduce anxiety, and smooth out the unpleasant physical manifestations of panic attacks.

The negative thing is that psychotropics can cause addiction. Based on this, they must be taken with extreme caution.

They all have side effects:

• dizziness, headache;
• increased level of irritability, aggressiveness;
• sexual dysfunctions;
• loss of appetite, insomnia;
• drowsiness, lethargy, fatigue, physical weakness;
• nausea, diarrhea, constipation, abdominal pain;
• decreased concentration.

The main disadvantage of using them to get rid of panic attacks is the instability of the result, i.e. attacks may recur if the medication is stopped.

What pills are most often used for panic attacks?

We can drink together

You can take medications together, but you should consider the following::

• Teraligen enhances the effect of Phenazepam and not only a sedative, but also a hypnotic effect will appear.
• The medicine is addictive, so you should not abuse the medication.

Doctors note that regular use of Teraligen has a calming effect and helps cope with depression or irritability, so Phenazepam is additionally recommended to be taken 1-2 times during an acute panic attack or unreasonable fear.

Contraindications

Can be used in complex therapy for patients with somatic, oncological, and dermatological diseases.

The use of the drug is limited when:

• pregnancy;
• breastfeeding;
• the patient is under 16 years of age;
• individual immunity of the body to the elements of the composition.

Substances included in the tablets can cause an allergic reaction, so patients with hypersensitivity to medicinal elements should prescribe the drug with caution.

Comparison of addiction between Fevarin and Teraligen

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “o syndrome” in Fevarin is quite similar to the similar values ​​in Teraligen. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Fevarin has quite a small amount of “syndrome”, just like Teraligen.

Atarax

Atarax is an anxiolytic and is prescribed for the treatment of chronic allergic diseases and neuroses. This drug is well tolerated by patients, it has few contraindications and side effects.

Atarax can have a relaxing effect on the internal (smooth) muscles, which helps relieve spasms and helps alleviate the condition during panic attacks.

It does not depress the central nervous system (CNS), but is capable of depressing some areas of the subcortical region.

The main active ingredient is a diphenylmethane derivative – hydroxyzine dihydrochloride.

Atarax has antihistamine and bronchodilator effects and does not affect gastric function in normal doses.

Atarax is also effective in the treatment of eczema, urticaria, itching in various allergic dermatitis, and can increase the total duration of sleep.

They do not cause memory impairment.

Atarax is absorbed quickly in the gastrointestinal tract and quickly enters the blood.

Atarax is used for the symptomatic treatment of itching, symptoms of anxiety, incl. panic attacks. Tablets of this medication are taken orally. Atarax in case of anxiety is recommended to take 0.05 g per day.

Atarax promotes the following side effects:

• headache, decreased blood pressure;
• transient decrease in vision clarity;
• increase in body temperature, general weakness, increased fatigue;
• dry mouth, in some cases - constipation, nausea, vomiting.

Atarax has the following contraindications: hereditary intolerance to galactose, porphyria, hypersensitivity to the components of the drug.

Atarax is contraindicated during pregnancy and breastfeeding.

Atarax enhances its effect when drinking alcohol, reduces the effect of phenytoin and epinephrine.

The results of an overdose of the drug "Atarax" are nausea, vomiting, stimulation or depression of the central nervous system, arrhythmia, hallucinations.

About tranquilizers

Tranquilizers or anti-anxiety drugs, sedatives.

A special group of drugs, and not only, that relax our nervous system.

Over the entire existence of medicine, a huge number of different anti-anxiety drugs have been invented. Unfortunately, many tranquilizers have not reached us or are included in the list of narcotic drugs, for example, the same Lemmon 714 from the film “The Wolf of Wall Street”

I would like to talk about the main tranquilizers that can be found in pharmacies.

Let's start from simple to complex. I must warn you that I compiled this list based on my experience of use, so here are mainly the drugs I often use.

Stresam (Etifoxine)

The lightest of all tranquilizers. The anti-anxiety effect is almost minimal, as are its side effects. Does not cause drowsiness or lethargy in an ordinary person. Suitable for particularly gentle individuals.

Grandaxin (Tofisopam).

It is considered a daytime tranquilizer that prevents drowsiness. The anti-anxiety effect is good. It is quite suitable for a person who has never taken psychotropic pills. A side effect (side effect) in the form of drowsiness, as a rule, occurs with a dose of more than one tablet per dose. Cheap, good, ordinary. Nothing supernatural.

Atarax (Hydroxyzine).

Initially, the drug was created as an antihistamine (supposedly against allergies), but it was found to have a good anti-anxiety effect. A good tranquilizer if used wisely. Some doctors prescribe a whole tablet of it two or three times a day, which makes patients extremely drowsy.

Although I noticed that there are people who can eat a pack and still get behind the wheel. Therefore, in a dose of one tablet it can be used as a sleeping pill. In general, the drug is good, there is a “risk” on the tablet: it is convenient to divide. In addition to drowsiness, it can cause dizziness and lethargy.

The drug has found itself not only in psychiatry, but also in dermatology: it relieves itching and can be prescribed as an antihistamine to particularly anxious patients.

Phenazepam (Elzepam, Phenorelaxan).

The most powerful and best tranquilizer available. Excellent anti-anxiety effect. The only disadvantage of this drug is its popularity and the huge number of stories about addiction.

Yes, it can really lead to addiction, but under certain conditions: you need to drink it uncontrollably in large doses of 3-5 mg per day for a long time, for months. No, you won’t become a drug addict after this, it causes depression and cognitive (memory loss) impairment, but you need to get to that point.

An excellent drug, if you take half a tablet three times a day, it won’t last long. It also has an arrhythmogenic effect. It works great when a person has never heard of it or read the instructions. Phenazepam can be used for hangover syndrome. Some students mix it with beer, which makes it doubly so.

Often used by older people for insomnia. In case of severe memory problems, it can provoke dementia, so anyone over 70 should use it with caution. The best companion for a panic attack is a phenazepam tablet under the tongue.

And we're almost at the end.

Alprozolam (Xanax, Helex).

The best of the best, but you won't find horseradish. It just kills the anxiety. You become so calm that if you see a “mushroom” from a nuclear explosion ahead, not a single muscle on your face will flinch. And this comes with a wonderful bonus: no drowsiness.

But why haven't you heard of him? Yes, because it is not so easy to find. It is issued according to the strictest prescription. But you can find it in the bins of a good psychiatrist.

If phenazepam does not work, then there is only one way out - comrade alprozolam (attention, this is not a public scam, it is addictive, so you need to consult a specialist).

There is also sibazon or relanium. It is mainly used in ambulances and I do not have any large data. It also calms well, but damn drowsiness.

And finally, you must understand that tranquilizers do not cure

. They are like an umbrella - good during bad weather. That is, during times of stress, at the beginning of taking antidepressants, or to urgently remove symptoms of fear. Treat with other drugs. Tranquilizers simply relieve symptoms. This is why we doctors like them: a pill – and you or your patient are calm. Fast. Reliable. Intramuscularly.

I specifically didn’t write anything about adaptol, afobazole, novopassit, etc., because they don’t work.

Bae Se: I’ll try for the sake of my three subscribers to make a post about antidepressants.

Source: https://pikabu.ru/story/pro_trankvilizatoryi_5800309

Afobazole and alcohol: compatibility

Afobazole has an anxiolytic effect, is able to remove fear and anxiety, and does not have a depressant effect on the central nervous system.

Afobazole is non-toxic.

Afobazole does not have muscle relaxant properties, i.e. does not reduce the tone of skeletal muscles, does not affect motor activity.

These tablets do not have a negative effect on attention and memory, and do not form drug dependence.

Afobazole does not contribute to the development of withdrawal syndrome.

This medicine acts in the form of mild stimulating and anti-anxiety effects. Used to eliminate panic attacks.

This medication can reduce the level of anxiety, fear, irritability, and bad feelings. Afobazole also helps relieve tension. All this makes it possible to remove a large number of cognitive, somatic, and vegetative symptoms.

Afobazole shows its effect on the 5-7th day of administration. Its maximum effect is achieved by the end of the 4th week, on average it lasts 1-2 weeks after the use is stopped.

Afobazole is advisable to use for people who have anxious suspiciousness, increased vulnerability, a tendency to emotional stress reactions, and uncertainty. It is often prescribed to treat panic attacks.

Afobazole should be taken from 2 to 4 weeks, sometimes up to 3 months. Tablets are taken orally after meals, 10 mg 3 times a day.

Afobazole is prescribed only to adults.

Contraindications are: hypersensitivity to its components, pregnancy, lactation. In case of overdose, sedation and increased drowsiness can be observed.

After using Afobazole tablets for nerves, it is unacceptable to drink alcohol. Any medications that directly affect the nervous system should not be combined with alcohol.

Alcohol can greatly enhance the effect of an anxiolytic, which will result in overdose, poisoning, or severe intoxication of the body.

There are known cases of death when large doses of Afobazole are combined with alcoholic beverages.

Indications for taking medications

Both drugs are strong anxiolytics and have an anti-anxiety effect. For what conditions are Afobazol and Phenazepam prescribed:

• somatic disorders;
• anxiety;
• panic attacks;
• neuroses;
• VSD;
• withdrawal syndrome in alcoholism;
• adaptation disorder in serious illnesses.

In addition, Afobazole is prescribed to relieve irritability when quitting smoking, PMS symptoms and hormonal disorders in menopausal women. Additional indications for taking Phenazepam are psychosis, some types of epilepsy and schizophrenia.

Side effects

Side effects are rare; most often patients complain of the development of allergies.

Therapy may also be accompanied by:

• headache;
• dizziness;
• mild depression, apathy.

If undesirable reactions are detected, you should consult your doctor; you may need to reduce the dose of the drug.

It is important to note that the above symptoms are not a reason to discontinue Afobazole as the main drug in the patient’s therapy.

What is better to choose

Medicines, although they belong to the same pharmaceutical group, differ in indications, active substance, mechanism of action on the central nervous system, duration of action and expected effect.

What is better - Phenazepam or Amitripline - is decided for a particular patient by the attending physician based on the diagnosis, manifestations of the disease, response to previous therapy, the presence of chronic pathologies and individual tolerance to the components of the drug.

If depression is established, then the prescription of an antidepressant is indicated. For hyperkinesis, sleep disturbance, increased nervousness, but without signs of depression, a tranquilizer is prescribed.

The use of both drugs should be under the supervision of a physician. The use of maximum doses is indicated only in a hospital setting.

Glycine

Glycine is a metabolic regulator, promotes activation and normalization of protective inhibition processes in the central nervous system, increases mental performance, removes psycho-emotional stress, making it useful in the treatment of panic attacks.

The main active component of the tablet is aminoacetic acid.

Glycine promotes:

• normalization of sleep;
• increasing mental performance;
• improving mood;
• reducing conflict and aggressiveness;
• reducing the degree of vegetative-vascular disorders.

Glycine easily penetrates biological fluids and body tissues, incl. into the brain. Its accumulation in tissues does not occur, since it is metabolized to water and carbon dioxide.

It is prescribed in the following cases:

• decreased mental performance;
• various functional, organic diseases of the nervous system, which are accompanied by sleep disturbances, decreased mental performance, excitability, emotional instability;
• stress.

It is also used in the treatment of panic attacks.

A contraindication for use is individual sensitivity to its components.

Glycine should be taken by the cheek (buccal) or under the tongue (sublingual).

Release form: tablets, 0.1 g.

Medicinal properties of the drug

The medicine is a psychotropic medication with neuroleptic and antipsychotic effects.

In a short time, the remedy can cope with various manifestations of mental disorders.

Teraligen is a psychotropic drug and is used for various mental disorders

Such disorders are often “treated” with alcohol. Therefore, it is necessary to find out whether Teraligen is compatible with alcohol.

Composition of the drug

The antipsychotic drug Teraligen contains the active ingredient alimemazine.

In addition to it, there are auxiliary components - sucrose, lactose, silicon dioxide, starch, tapioca, magnesium stearate, talc.

Purpose and indications for use

The drug exhibits an antihistamine effect, partially blocking histamine receptors that are located in the brain.

Alimemazine suppresses the activity of the cough and vomiting center, has an antitussive and antiemetic effect. The medicine acts moderately as a hypothermic and antispasmodic agent.

It is not used to eliminate acute or severe forms of psychotic disorders due to its weak antipsychotic effect.

The drug has many other therapeutic effects, therefore it has the following indications:

1. psychosomatic disorders;
2. obsessive and anxious states;
3. phobias;
4. insomnia and similar sleep disorders;
5. painful sensations associated with functional or organic pathology of important organs;
6. neurovegetative pathologies;
7. hacking cough;
8. allergic diseases - asthma;
9. persistent gag reflex.

It can be prescribed to a patient after treatment for alcohol addiction during a period of remission.

The drug copes well with psychomotor agitation in such patients, reduces the frequency of hallucinations, and restores sleep.

Teraligen can be prescribed for remission after treatment of alcoholism

The effect of the drug occurs twenty minutes after administration, its maximum concentration in the blood is reached after two hours.

The medicine continues to act for 6-8 hours. The liver processes the substance and is excreted from the body naturally through urine.

The medication is prescribed in the form of oral tablets or as a solution for intramuscular or intravenous use. Depending on the severity of the patient's condition and the type of disorder, the dosage of the medicine may be different.

Combination of Teraligen with alcohol

You should find out from your doctor whether Teraligen is compatible with alcohol. According to the instructions, drinking alcohol and treatment with alimemazine are incompatible.

The main reason for this incompatibility is the hepatotoxicity of alimemazine. Alcohol-containing drinks exacerbate the negative effect of the drug on hepatocytes.

Compatibility between Teraligen and alcohol should not be allowed. Only after a single dose of the medicine does the liver work intensively for two hours.

If it is necessary to take the drug for a long time, the liver is constantly under stress.

Experts say that the combination of Teraligen with alcohol is incompatible

When drinking alcohol and Teraligen at the same time, the consequences are severe - under the influence of alcohol, hepatocytes begin to work hard to process ethanol. As a result, inactivation of alimemazine and alcohol is difficult.

According to reviews, Teraligen with alcohol increases the level of a dangerous substance in the blood - acetaldehyde. Doctors know about this and try to convey information to their patients.

The substance has much more toxic properties compared to alcohol itself. Under its influence, the liver is subject to destructive effects.

Alcohol has a stimulating effect on the body and the central nervous system, while the drug exhibits the opposite activity, suppressing the active activity of the nervous system and brain.

There are medical reviews about the compatibility of alcohol and Teraligen - when experiencing the effects of two different substances, the nervous system refuses to “understand” what they want from it.

Grandaxin

Grandaxin is a short-acting anxiolytic that does not cause anticonvulsant, muscle relaxant, or sedative effects.

It, like other antidepressants, improves intellectual and psychomotor functions and provides protection against stress. It is also used in the treatment of PA. The tablets are absorbed into the blood quickly, reaching the maximum concentration within an hour and a half.

Grandaxin is produced in the form of white or grayish-white round tablets, odorless or almost odorless, with 2 flat sides.

Grandaxin can be prescribed for neuroses, somatic and mental disorders that are accompanied by bad mood, apathy, fear, anxiety, obsessive feelings (including panic attacks), post-traumatic stress disorder, reactive depression.

Grandaxin is taken orally, the daily dose (determined individually) is in the range of 50-300 mg.

Grandaxin is contraindicated in psychopathy, psychosis, major depression, aggressiveness, pregnancy, breastfeeding, hypersensitivity to benzodiazepines.

Grandaxin can cause itching of the skin, nausea, gastralgia, as well as sleep disturbances, excitability, and aggressiveness.

In case of overdose, Grandaxin causes drowsiness and slight respiratory depression.

About Phenazepam

This drug is very effective. This powerful tranquilizer has a muscle relaxant, anticonvulsant, sedative and hypnotic effect on the human body. The medicine is used mainly to treat emotional disorders that arise from an imbalance in the nervous system . The complex and very effective effect of the drug on the entire human body is a great advantage over its analogues.

Indications for use

• Insomnia, sleep problems
• Intrusive thoughts
• Schizophrenia
• Depressive states
• Obsessive feelings of fear, anxiety and restlessness
• Panic attacks
• Post-traumatic shock
• Alcohol withdrawal
• Nervous tics, seizures

To find out which is better, Amitriptyline or Phenazepam, you need to understand what kind of drug it is - Amitriptyline.

Instructions for use

How to take Afobazol tablets for adults:

1. The drug is intended for oral administration.
2. Doctors recommend taking tablets not on an empty stomach, but after meals. This will reduce the negative effects of medicinal components on the stomach.
3. Do not chew or dissolve the tablet. Drink with a small amount of water.
4. A single dosage should not exceed 10 mg.
5. The optimal daily dose is 30 mg, divided into several doses.

Children/adolescents over the age of eighteen are not recommended to exceed the daily dose above 20 mg.

To achieve a positive therapeutic effect, it is necessary to follow a treatment course lasting 2-3 weeks.

For patients with severe forms of psycho-emotional disorders, the daily dosage can be increased to 60 mg, and the therapeutic course extended to 3 months.

Comparison of the effectiveness of Fevarin and Teraligen

The effectiveness of Fevarin is quite similar to Teraligen - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Fevarin is more pronounced, then using Teraligen even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Fevarin and Teraligen. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Phenazepam

Phenazepam is a benzodiazepine tranquilizer developed in 1974. Today it is considered a highly effective safe drug. These tablets, like all tranquilizers, have a calming effect on the central nervous system.

Phenazepam is superior to other tranquilizers in its tranquilizing and anti-anxiety effects. This medicine has anticonvulsant and muscle relaxant effects and may cause drowsiness. If phenazepam is used together with sleeping pills and narcotic drugs, their effects will be mutually reinforcing.

Phenazepam is used for neurotic, neurosis-like, psychopathic, psychopathic conditions, accompanied by emotional instability, anxiety, fear, increased levels of irritability, incl. to get rid of panic attacks.

Phenazepam has an effective effect on various phobias, obsessive states, and helps overcome hypochondriacal syndromes, incl. resistant to the effects of other tranquilizers. Phenazepam is also used for psychogenic psychoses, to eliminate panic attacks, etc., because it removes the state of anxiety and fear. Phenazepam is not inferior to individual antipsychotics in its calming effect on the central nervous system.

Such tablets can also be prescribed as an anticonvulsant and hypnotic, and used in preparation for surgical operations. In terms of the strength of its hypnotic effect, phenazepam is close to eunoctine.

Phenazepam should be taken orally in tablet form 2-3 times a day.

Contraindications to the use of the drug are dysfunction of the liver, kidneys, myasthenia gravis (severe muscle weakness), pregnancy, severe depression, organic diseases of the brain, acute respiratory failure.

Phenazepam can cause the following side effects:

• allergic reactions;
• anemia, sore throat, hypothermia, chills;
• diarrhea, constipation, salivation, dry mouth, decreased appetite, nausea, vomiting, heartburn;
• impaired renal function;
• increase or decrease in libido;
• decreased ability to concentrate, drowsiness, feeling tired.

In case of overdose, phenazepam can provoke a decrease in blood pressure, difficulty breathing or shortness of breath, drowsiness, prolonged confusion, etc.

Amitriptyline and phenazepam: can they be taken at the same time (compatibility)diabet doctor

Dosage forms of Tranquesipam:

• solution for intravenous (i.v.) and intramuscular (i.m.) administration: lightly colored liquid (1 ml per ampoule: 10 ampoules in a cardboard box; 5 ampoules in blister packs or plastic trays, 2 packs in a cardboard box or pallet);
• tablets: flat-cylindrical, white, with a bevel (10 pcs. in blister packs, 5 packs in a cardboard pack; 50 pcs. in a dark glass jar or polymer jar, 1 jar or jar in a cardboard pack).

1 ml of Tranquesipam solution contains:

• active ingredient: bromodihydrochlorophenylbenzodiazepine – 1 mg;
• auxiliary components: distilled glycerin (glycerol), polysorbate (Tween-80), povidone (medical low molecular weight polyvinylpyrrolidone 12 600 ± 2700), sodium hydroxide solution 0.1 M (up to pH 6–7.5), sodium metabisulfite (sodium disulfite) , water for injections.

1 tablet of Tranquesipam contains:

• active ingredient: bromodihydrochlorophenylbenzodiazepine – 0.5 mg or 1 mg;
• auxiliary components: calcium stearate, potato starch, milk sugar (lactose monohydrate), medical gelatin.

Price

The average cost for 50 tablets of 1 mg is 140 rubles, for 10 ampoules of 1 ml – 185 rubles.

You can purchase the drug only with a doctor's prescription, and the prescription must remain in the pharmacy.

Phenazepam is often used off-label.

Drug addicts who take pills and inject Phenazepam to achieve a state of euphoria and hallucinations experience great sympathy for the drug. However, it is impossible to purchase the drug on the open market; the prescription is written in Latin, so it is almost impossible to forge a prescription.

Reviews about tranquilizers

The use of sedatives is possible only as prescribed by a doctor. Therefore, you should not choose your own medications, focusing only on the opinions of other people.

According to many patients, tranquilizers help to quickly restore peace of mind, get rid of sleep problems and relax muscles. But at the same time, people often note that all the advantages of such medications are offset by possible side effects. They are especially noticeable in older people. Weakness, depression of all vital functions, and deterioration in mood are often noted.

This condition occurs if you use Fesipam, Diazepam, Elzepam and other analogues. "Phenazepam" is also no exception. But even those patients who tolerated these drugs easily and did not notice any side effects say that the drug is addictive.

Indications of medications

Fenzitate and Phenazepam have the same indications for use. Most often, diseases and conditions for which you need to take these medications are associated with various psychopathy, neuroses and neurosis-like conditions, which are accompanied by a number of symptoms:

• excessive suspiciousness;
• obsessive thoughts;
• panic;
• anxiety;
• causeless fear;
• increased irritability;
• state of tension;
• excitement;
• mood swings.

Drugs can be given to reduce the effects of prolonged stress when it is not possible to cope with the problem on your own. What else do pills help with? Indications also include different types of sleep disorders - poor falling asleep, changes in sleep phases, early awakening.

Drugs can help with some phobias, as well as with reactive psychosis.

Both medications are indicated for seizures of various origins. To relax muscles, they are prescribed for certain types of epilepsy, tics, muscle rigidity, and hyperkinesis. The tablet is given once to patients before anesthesia to relieve anxiety.

In complex treatment, they are given to people with schizophrenia, but we must remember that Phenazepam and Fenzitate do not affect delusions, hallucinations and other similar symptoms.

Pharmacodynamics

Tranquesipam is a tranquilizer, a benzodiazepine drug with anxiolytic, sedative, hypnotic, anticonvulsant and central muscle relaxant effects.

The mechanism of its action is associated with increased inhibition of the effect of gamma-aminobutyric acid on the transmission of nerve impulses, inhibition of polysynaptic spinal reflexes, stimulation of binding sites with benzodiazepines, which are located in the allosteric center of postsynaptic gamma-aminobutyric acid receptors.

Tranquesipam helps reduce the excitability of subcortical brain structures such as the limbic system, hypothalamus, and thalamus.

A manifestation of the anxiolytic effect is a decrease in emotional stress, a weakening of feelings of fear, anxiety, and restlessness.

The influence of the active substance on the reticular formation of the brain stem and nonspecific nuclei of the thalamus causes the sedative effect of Tranquesipam, which reduces the manifestations of symptoms of neurotic origin.

The hypnotic effect is associated with inhibition of the cells of the reticular formation of the brain stem, as a result of which the impact of vegetative, emotional, and motor stimuli on the mechanism of falling asleep is reduced.

The anticonvulsant effect is associated with increased presynaptic inhibition, as a result of which only the propagation of the convulsive impulse is suppressed, while the state of excitation in the focus itself is preserved.

The central muscle relaxant effect of Tranquesipam becomes possible mainly due to the inhibition of polysynaptic spinal reflexes and, to a lesser extent, the inhibition of monosynaptic spinal reflexes. In addition, direct inhibition of motor nerves and muscle contractility is possible.

Pharmacokinetics

After taking Tranquesipam tablets orally, the drug is rapidly absorbed from the gastrointestinal tract, which allows it to reach maximum concentration in the blood plasma within 1–2 hours. The active substance is characterized by a wide distribution in the body. Metabolism of bromodihydrochlorophenylbenzodiazepine occurs in the liver.

The half-life is 6–18 hours.

It is excreted from the body in the form of metabolites mainly through the kidneys.

Contraindications and side effects

• closed-angle glaucoma (including those with a predisposition to it);
• severe form of chronic obstructive pulmonary disease;
• acute respiratory failure;
• coma;
• shock;
• myasthenia gravis;
• pregnancy period;
• breast-feeding;
• age under 18 years;
• hypersensitivity to other benzodiazepine drugs;
• individual intolerance to the components of Tranquesipam.

In addition, additional contraindications for the use of tablets:

• acute poisoning with narcotic analgesics, hypnotics and alcohol, accompanied by a weakening of vital functions;
• glucose-galactose malabsorption syndrome, lactose intolerance, lactase deficiency;
• severe form of depression.

Caution should be exercised when prescribing Tranquesipam to patients prone to abuse of psychoactive drugs, with liver and/or renal failure, cerebral and spinal ataxia, a history of drug dependence, hyperkinesis, organic diseases of the brain, psychosis, hypoproteinemia, established or suspected sleep apnea, in old age.

The drugs are strictly contraindicated in severe stages of obstructive pulmonary disease and other serious pathologies of the respiratory system. The strictest prohibition is lactation and the first trimester (further on during gestation, medications are also contraindicated).

Other prohibitions on treatment:

• coma, shock;
• tendency or presence of angle-closure glaucoma;
• age under 18 years;
• intolerance to any benzodiazepines.

Under the supervision of a doctor, therapy is carried out for liver and kidney dysfunctions, organic brain diseases, and depressive states. In old age, treatment is carried out only when absolutely necessary. Medicines are not sold without a prescription as they are addictive. Therefore, it is better not to prescribe them to people with a tendency to abuse psychotropic drugs.

Side effects may also include blood disorders, disorientation, headaches, muscle spasms, dry mouth, nausea, and heartburn. Diarrhea or constipation, changes in libido, and menstrual irregularities may be recorded.

Over-the-counter similar products

There are over-the-counter analogues of Phenazepam on the pharmacological market. These medications have a similar therapeutic direction to Phenazepam, but have minimal toxic effects on the patient’s body.

Source: https://rptp-rd.ru/preparaty/trankvezipam-i-fenazepam-otlichiya.html

Reviews from people after use

I recently became acquainted with Afobazol after visiting a neurologist. Regular stress at work led to insomnia, for which the specialist recommended Afobazol. Before starting therapy, I carefully studied what the drug helps with. One of the areas of action of the tablets is the normalization of sleep-wake patterns.

In the first days of taking the pills, I didn’t notice any special changes. Improvements began on days 6-7. I began to fall asleep quickly, my sleep became sound and long. In addition, I noticed an improvement in my overall emotional background, was less tired at work, and stopped getting irritated by various little things.

After the birth of my child, I began to experience a postpartum crisis. When I realized that I couldn’t cope on my own, I turned to a neurologist. The doctor said that it is advisable to wait until the end of the lactation period and then begin therapy.

As prescribed by the doctor, I started taking Afobazole, three tablets a day. The neurologist immediately warned that the effect of the tablets is cumulative, that is, the result will not be noticeable immediately.

Since I was in a serious psycho-emotional state, the therapeutic course was long - for three months. I feel much better now and fully enjoy motherhood. A good drug, and there were no side effects from it.

In general, patient reviews are positive. A small percentage of patients complain of headaches, occasional dizziness and allergic reactions.

Compatibility with other drugs

It is strictly prohibited to use neuroleptics together with sleeping pills. Since such a combination can even cause death. However, many people forget that there is a huge list of drugs with which psychotropic drugs are also not combined. That is why it is so important that the decision to include Teraligen in therapy is made by a specialist. Only he can determine how effective the therapy will be, and what means it can be supplemented with so as not to harm the patient.

The simultaneous use of substances with different effects, for example, Teraligen and alcohol, can cause a completely unpredictable reaction from the body.

It is important to avoid simultaneous use of Teraligen and alcohol; the consequences can be very dangerous.

It is important to know whether Teraligen can be taken with alcohol, and if not, then why. It happens that friends unexpectedly come to visit, they invite you to celebrate some event at work, or a date ends with dinner at a restaurant.

In such situations, strong drinks are present and the question may arise: is Teraligen compatible with alcohol? If you took Teraligen in the morning, how long after can you drink alcohol so as not to harm your health?

Reviews from doctors

Afobazole is a new generation selective anxiolytic used for mental disorders of mild to moderate severity. Requires strict adherence to dosage, depending on the patient’s diagnosis.

It is strictly unacceptable to use the medicine for self-medication; how to take Afobazole should be determined by the attending physician depending on the patient’s condition.

Therapy with Afobazol gives positive results in the treatment of 96% of patients. For severe forms of the disease, I prescribe complex therapy in combination with other antipsychotics.

The advantages of the drug include good tolerability by patients and a minimal number of adverse reactions, which occur in no more than 20% of patients.

Neurologists speak positively about the effect of the drug, so they trust it with the health of their patients.

Phenazepam analogues: comparison of drugs and list of over-the-counter products

Phenazepam is a strong medication that can have a pronounced effect on the human psyche. It belongs to the pharmacological group of tranquilizers and is capable of causing hypnotic, muscle relaxant and antiepileptic effects. This drug should be prescribed only under the supervision of a physician of the appropriate specialty, as there is a risk of complications and adverse reactions in response to its use. If for some reason the drug Phenazepam is not suitable for you, analogues for selecting and prescribing a new treatment regimen should only be selected together with the treating doctor, who is well acquainted with the features of the clinical case. Never self-medicate, because an incorrectly selected pharmaceutical drug or dosage can cause irreparable harm to your health.